18 Questions
What is the preparatory step that inflammation provides before healing and immune response?
Getting rid of microbes and necrotic tissue
Which term describes the dynamic response of vascularized living tissue to injury?
Inflammation
What is the main aim of inflammation?
To get rid of microbes and necrotic tissue
Which event characterizes acute inflammation?
Rapid onset and short duration
What is the main difference between exudate and transudate?
Amount of protein content
What does the term 'granuloma' refer to in the context of inflammation?
An organized collection of immune cells
What does dermatitis mean?
Inflammation of skin
Which type of cells are predominant in chronic inflammation?
Macrophages
What is the main aim of acute inflammation?
Deliver leukocytes and plasma proteins to the site of infection or injury
What does gastritis mean?
Inflammation of stomach
Which type of immunity is associated with acute inflammation?
Innate immunity
What is the role of vasodilation in acute inflammation?
Increase vascular permeability
What is the main purpose of vascular reaction in inflammation?
Enhancing capillary permeability for leukocyte migration
Which mechanism leads to increased capillary permeability in inflammation?
Formation of vesiculo-vacuolar organelles
What process is mediated by interconnected uncoated vesicles and vacuoles in inflammation?
Transcytosis
What type of injury causes endothelial cells to undergo detachment in inflammation?
Apoptosis induced by neutrophils
Which molecule plays a role in increasing inter-endothelial space and capillary permeability?
Histamine
What is the primary effect of increased capillary permeability during inflammation?
Formation of exudate leading to swelling
Study Notes
Pathology: The Science of Studying Diseases
- Etiology, Pathogenesis, Morphological changes, and Fate & Complications are the main components of studying diseases
Inflammation
- Definition: Dynamic response of vascularized living tissue to injury
- Aim: Protective mechanism to get rid of microbes and necrotic tissue
- Characteristics: Red, hot, pain
Vascular Reaction in Inflammation
- Aim: Increase blood flow and vascular permeability
- Mechanisms:
- Vasodilation with increased blood flow
- Increase vascular permeability (protein and cells) through:
- Contraction of endothelial cells
- Endothelial cell injury
- Transcytosis
Causes of Inflammation
- Physical: Trauma, Heat, Radiation, Cold
- Chemical: Acids, Alkali, Poisons
- Infection: Bacteria, Viruses, Fungi, Parasites
- Immunological: Antigen-antibody, Cell-mediated
Types of Inflammation
- Acute Inflammation:
- Definition: Rapid host response to deliver leukocytes and plasma protein to site of infection or tissue injury
- Characteristics: Sudden onset, rapid, short duration, prominent vascular response
- Chronic Inflammation:
- Characteristics: Gradual onset, slow, long duration, less prominent vascular response
Leukocytes Journey
- Steps:
- Increase vascular permeability
- Leukocytes migration
- Chemotaxis (movement of cells towards a chemical stimulus)
- Phagocytosis (engulfing of foreign particles or bacteria)
Abscess
- Definition: Localized collection of pus
- Mechanism of formation: Accumulation of leukocytes and dead tissue
- Example: Pus-filled cavity in the skin
- Fate: May resolve or lead to chronic inflammation
Comparison between Abscess and Cellulitis
- Abscess: Localized collection of pus
- Cellulitis: Inflammation of subcutaneous tissue
Test your knowledge on inflammation, exudate formation, and related concepts in the field of pathology. Questions cover the definition, causes, symptoms, types, and events of acute inflammation, as well as the mechanism and differences between exudate and transudate formation.
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