Pathology Chapter 1: Introduction and Cellular Pathology

Study Notes

Pathology Curriculum Map

The curriculum map consists of 16-20 lectures divided into 10 chapters
The chapters include Introduction, Cell injury, Tissue deposits, Inflammation, Repair, Disorders of growth, Neoplasia, Disorders of blood flow, Infectious diseases, and Environmental & nutritional diseases

Pathology Assessment Map

The assessment map consists of a final written exam (40%), oral sheet (10%), practical exam (25%), midterm (15%), and course work (10%)

Pathology

Etiology involves predisposing factors, exciting factors, pathogenesis, clinical picture, and prognosis
Clinical picture includes symptoms, signs, and complications
Pathogenesis involves mechanism, morphology, gross picture, and microscopic picture

Gross Picture

Gross picture is the study of obtained diseased tissue regarding size, site, shape, surface, capsule, color, consistency & borders, and cut section

Microscopic Picture

Microscopic picture involves histopathological features and structural changes in tissues and organs
H & E stain is universally used
Special stains are used to demonstrate intra & extra cellular materials:
Periodic acid Schiff stain (PAS) for glycogen and basement membranes
Trichrome stain for collagen
Prussian blue reaction for hemosidrin
Alcian blue stain for mucin
Sudan III & Osmic acid for lipids
Congo red stain for amyloid
Immunohistochemistry is the application of immunologic principles and techniques to the study of cells and tissues
Immunohistochemistry is useful in diagnosis of malignant undifferentiated tumors, classification of tumors, detection of primary site of metastatic deposits, planning therapeutic protocols, and prediction of tumor behavior & response to therapy
Immunostaining may be nuclear, cytoplasmic, or membranous

Specimens

Types of pathological specimens include tissue and cellular specimens
Tissue specimens include whole organ, biopsy, and autopsy
Biopsy is a sample from affected tissue and can be excision biopsy or incision biopsy
Incision biopsy can be punch biopsy, endoscopic biopsy, or core cut needle biopsy
Autopsy involves postmortem specimens taken from organs and tissues to determine the cause of death
Cellular specimens (cytology) involve examination of diseased cells and include exfoliated cells, cells in body fluids, effusion fluid, and body discharge

Description

This quiz covers the basic concepts of pathology, including cell injury, tissue deposits, inflammation, repair, and disorders of growth. It is designed for students in the Pathology Curriculum map, Spring 2023-2024.