RBC Membrane Pathology
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Questions and Answers

What is the average life span of a red blood cell (RBC)?

  • 180 days
  • 90 days
  • 150 days
  • 120 days (correct)

    • What happens to non-deformable RBCs with membrane disorder pathology?

  • They are further damaged and cleared by splenic macrophages (correct)
  • They are strengthened and stabilized
  • They are recycled for reuse
  • They become more flexible and durable

    • Which type of hemoglobin accounts for 96-98% of adult hemoglobin?

  • HbA = ⍺2β2 (25%)
  • HbA = ⍺2β2 (96-98%) (correct)
  • HbF = ⍺2γ2 (75%)
  • HbA2 = ⍺2δ2 (2-3%)

    • Explain the role of the RBC membrane in balancing strength and flexibility. What are the consequences of alterations in this balance?

    <p>The RBC membrane plays a crucial role in balancing strength and flexibility. Alterations in this balance can lead to RBC fragility, injury, and shortened life span. Non-deformable RBCs may be formed and further damaged, leading to clearance from the circulation by splenic macrophages.</p> Signup and view all the answers

    Describe the pathology of membrane disorders in RBCs, focusing on the weakness in vertical linkages among cytoskeletal proteins and destabilization of the lipid bilayer.

    <p>Membrane disorder pathology commonly involves weakness in the vertical linkages among the cytoskeletal proteins, destabilizing the lipid bilayer. This can result in the formation of non-deformable RBCs, which are further damaged and cleared from the circulation by splenic macrophages.</p> Signup and view all the answers

    Provide the composition and percentages of different types of hemoglobin, including HbF, HbA, and HbA2.

    <p>HbF is composed of ⍺2γ2 (75%), HbA is composed of ⍺2β2 (96-98%), and HbA2 is composed of ⍺2δ2 (2-3%).</p> Signup and view all the answers

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