RBC Membrane Pathology

180 days

90 days

150 days

120 days (correct)

They are further damaged and cleared by splenic macrophages (correct)

They are strengthened and stabilized

They are recycled for reuse

They become more flexible and durable

HbA = ⍺2β2 (25%)

HbA = ⍺2β2 (96-98%) (correct)

HbF = ⍺2γ2 (75%)

HbA2 = ⍺2δ2 (2-3%)

<p>The RBC membrane plays a crucial role in balancing strength and flexibility. Alterations in this balance can lead to RBC fragility, injury, and shortened life span. Non-deformable RBCs may be formed and further damaged, leading to clearance from the circulation by splenic macrophages.</p> Signup and view all the answers

<p>Membrane disorder pathology commonly involves weakness in the vertical linkages among the cytoskeletal proteins, destabilizing the lipid bilayer. This can result in the formation of non-deformable RBCs, which are further damaged and cleared from the circulation by splenic macrophages.</p> Signup and view all the answers

<p>HbF is composed of ⍺2γ2 (75%), HbA is composed of ⍺2β2 (96-98%), and HbA2 is composed of ⍺2δ2 (2-3%).</p> Signup and view all the answers