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Questions and Answers
What is the average life span of a red blood cell (RBC)?
What is the average life span of a red blood cell (RBC)?
- 180 days
- 90 days
- 150 days
- 120 days (correct)
What happens to non-deformable RBCs with membrane disorder pathology?
What happens to non-deformable RBCs with membrane disorder pathology?
- They are further damaged and cleared by splenic macrophages (correct)
- They are strengthened and stabilized
- They are recycled for reuse
- They become more flexible and durable
Which type of hemoglobin accounts for 96-98% of adult hemoglobin?
Which type of hemoglobin accounts for 96-98% of adult hemoglobin?
- HbA = ⍺2β2 (25%)
- HbA = ⍺2β2 (96-98%) (correct)
- HbF = ⍺2γ2 (75%)
- HbA2 = ⍺2δ2 (2-3%)
Explain the role of the RBC membrane in balancing strength and flexibility. What are the consequences of alterations in this balance?
Explain the role of the RBC membrane in balancing strength and flexibility. What are the consequences of alterations in this balance?
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Describe the pathology of membrane disorders in RBCs, focusing on the weakness in vertical linkages among cytoskeletal proteins and destabilization of the lipid bilayer.
Describe the pathology of membrane disorders in RBCs, focusing on the weakness in vertical linkages among cytoskeletal proteins and destabilization of the lipid bilayer.
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Provide the composition and percentages of different types of hemoglobin, including HbF, HbA, and HbA2.
Provide the composition and percentages of different types of hemoglobin, including HbF, HbA, and HbA2.
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