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Questions and Answers
What is disease defined as?
What is disease defined as?
An abnormal alteration of structure or function in any part of the body
What is the focus of systemic pathology?
What is the focus of systemic pathology?
Disease affecting a specific organ or system
What is the backbone of disease diagnosis, understanding, and treatment?
What is the backbone of disease diagnosis, understanding, and treatment?
Knowledge of etiology
What is an etiologic agent?
What is an etiologic agent?
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What are predisposing causes of disease?
What are predisposing causes of disease?
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What are exciting causes of disease?
What are exciting causes of disease?
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What is a neoplasm?
What is a neoplasm?
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What type of disease is caused by genetic or congenital factors?
What type of disease is caused by genetic or congenital factors?
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What is hypertrophy?
What is hypertrophy?
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What is anaplasia?
What is anaplasia?
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What is oral pathology?
What is oral pathology?
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What is metaplasia?
What is metaplasia?
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What is atrophy?
What is atrophy?
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What is hyperkeratosis?
What is hyperkeratosis?
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What is pedunculated?
What is pedunculated?
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What is diffuse?
What is diffuse?
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What is Fordyce granules?
What is Fordyce granules?
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What is the typical location of Fordyce granules?
What is the typical location of Fordyce granules?
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What is White Spongy Naevus?
What is White Spongy Naevus?
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What is the characteristic appearance of White Spongy Naevus?
What is the characteristic appearance of White Spongy Naevus?
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What are Bohn's nodules?
What are Bohn's nodules?
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What is the location of Bohn's nodules?
What is the location of Bohn's nodules?
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What is Aglossia?
What is Aglossia?
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What is the characteristic histopathology of Fordyce granules?
What is the characteristic histopathology of Fordyce granules?
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What does 'hard' refer to in terms of a physical property?
What does 'hard' refer to in terms of a physical property?
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What is metastasis?
What is metastasis?
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What is a mutation?
What is a mutation?
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What is asymmetric overgrowth of one or more body parts?
What is asymmetric overgrowth of one or more body parts?
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What is an oblique facial cleft?
What is an oblique facial cleft?
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What is a transverse facial cleft?
What is a transverse facial cleft?
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What is facial hemi-hypertrophy or –atrophy?
What is facial hemi-hypertrophy or –atrophy?
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What is the sex predilection of facial hemi-hypertrophy or –atrophy?
What is the sex predilection of facial hemi-hypertrophy or –atrophy?
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What is the characteristic feature of geographic tongue?
What is the characteristic feature of geographic tongue?
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What is the possible etiology of geographic tongue?
What is the possible etiology of geographic tongue?
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What is the histological feature of geographic tongue?
What is the histological feature of geographic tongue?
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What is the origin of lingual thyroid nodule?
What is the origin of lingual thyroid nodule?
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Where is the lingual thyroid nodule typically located?
Where is the lingual thyroid nodule typically located?
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What is the suggested relationship between hormonal factors and lingual thyroid nodule?
What is the suggested relationship between hormonal factors and lingual thyroid nodule?
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What is the appearance of the lingual thyroid nodule?
What is the appearance of the lingual thyroid nodule?
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What is the characteristic feature of hyaline degeneration of muscles?
What is the characteristic feature of hyaline degeneration of muscles?
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Study Notes
Classification of Pathology
- General pathology: Deals with basic alterations and general characteristics of major disease categories
- Systemic pathology: Deals with diseases affecting specific organs or systems
- Oral pathology: A branch of systemic pathology that deals with diseases affecting the soft and hard oral tissues, including the teeth
Disease and Etiology
- Disease: An abnormal alteration of structure or function in any part of the body
- Etiology: The study of the cause of a disease
- Importance of etiology: Remains the backbone of disease diagnosis, understanding the nature of diseases, and treatment of diseases
- Etiologic agent: The factor responsible for lesions or a disease state
- Types of causes of disease:
- Predisposing causes: Factors that make an individual more susceptible to a disease
- Exciting causes: Factors directly responsible for a disease
Classification of Diseases
- Developmental: Genetic or congenital
- Acquired: Genetic feature resulted from an extrinsic factor during development
- Inflammatory: Trauma, infections, immune, etc.
- Neoplasm: Abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissue
- Hypertrophy: Increase in the size of an organ or tissue due to an increase in the size of the cells
- Hyperplasia: Increase in the size of an organ or tissue due to an increase in the number of cells
Index for Scientific Terms
- Anaplasia: Reversal of highly differentiated cells into a less differentiated type
- Metaplasis: Reversible replacement of one differentiated cell type with another mature differentiated cell type
- Aplasia: Complete failure of formation of an organ or tissue
- Hypoplasia: Incomplete development of an organ or tissue
- Atrophy: Decrease in the size of an organ or tissue after complete formation
- Hyperkeratosis: Thickening of the stratum corneum
- Acanthosis: Thickening or widening of the stratum spinosum
- Spongiosis: Intercellular edema
- Acantholysis: Separation of cells in stratum spinosum resulting in intraepithelial split
- Pedunculated: Attached by a stemlike or stalk base
- Sessile: Describing the base of a lesion that is flat or broad instead of stemlike
- Diffuse: Describing a lesion with borders that are not well defined
- Exophytic:
- Firm: Strongly felt and unlikely to change
- Cheesy: Like cheese in consistency
- Hard: Not easily broken or bent
- Metastasis: Spread of a tumor or cancer to distant parts of the body from its original site
- Mutation: Relatively permanent change in hereditary material
Developmental Anomalies Associated with Asymmetric Growth
- Asymmetric overgrowth of one or more body parts, mostly represents a hyperplasia of the tissues rather than a hypertrophy
- Etiology: Obscure, but various theories include vascular or lymphatic abnormalities, CNS disturbances, endocrine dysfunction, aberrant twinning mechanisms, and chromosomal anomalies
Developmental Disturbances of the Face
- Orofacial clefts:
- Oblique facial cleft: Developmental cleft starting from the inner canthus of the eye to the ala of the nose or upper lip
- Transverse facial cleft: Cleft running from the angle of the mouth towards the ear
- Facial hemi-hypertrophy or atrophy:
- 2:1 in females, more on the right side, often noted at birth or later in childhood
- 20% are mentally retarded
Developmental Anomalies of the Oral Mucosa
- Fordyce granules:
- Ectopic condition in which sebaceous glands develop in the oral mucosa
- Clinical appearance: Single or multiple pinhead-sized spots appear symmetrically located most frequently in the buccal mucosa
- Histopathology: Normal sebaceous glands without hair follicles
- White spongy naevus (white folded gingivostomatitis):
- Hamartoma in skin or mucous membrane
- Clinical appearance: Grayish-white spongy areas of the oral mucosa with folds and it is soft upon palpation
- Histopathology: Prickle cell layer shows acanthosis with inter- and intracellular edema or vacuolation giving the basket-weave appearance with surface hyperkeratosis
- Bohn's nodules:
- Small, discrete, whitish swellings occurring in the gingivae of infants
- Represent small cysts that arise from degeneration of remnants of the dental lamina
- Are keratin cysts derived from remnants of odontogenic epithelium over the dental lamina or may be remnants of minor salivary glands
Developmental Anomalies of the Tongue
- Aglossia: Complete absence of the tongue; very rare, may be associated with agnathia
- Geographic tongue (benign migratory glossitis):
- Unknown etiology, may be related to emotional stress, immunosuppression, and Candidal infection
- Clinical appearance: Multiple, irregular or circular, depapillated areas, fungiform papillae persist as small elevated red dots
- Histologically: Filliform papillae are lost, at the margins hyperparakeratosis and some acanthosis, polymorphs and lymphocytes are seen within the epithelium, producing epithelial degeneration and microabscess formation, special stains reveal Candidal hyphae within the epithelium
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Description
Learn about the basics of pathology, including classification, general pathology, and systemic pathology. Understand what constitutes a disease and how it affects the body.