Pathology Basics
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Pathology Basics

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Questions and Answers

What is disease defined as?

An abnormal alteration of structure or function in any part of the body

What is the focus of systemic pathology?

Disease affecting a specific organ or system

What is the backbone of disease diagnosis, understanding, and treatment?

Knowledge of etiology

What is an etiologic agent?

<p>A factor responsible for lesions or a disease state, such as a bacterium or virus</p> Signup and view all the answers

What are predisposing causes of disease?

<p>Factors that make an individual more susceptible to a disease, such as damp weather or poor ventilation</p> Signup and view all the answers

What are exciting causes of disease?

<p>Factors directly responsible for a disease, such as hypoxia or chemical agents</p> Signup and view all the answers

What is a neoplasm?

<p>Abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissue and persists in the same excessive manner even after the cessation of the stimulus that evoked the change.</p> Signup and view all the answers

What type of disease is caused by genetic or congenital factors?

<p>Developmental disease</p> Signup and view all the answers

What is hypertrophy?

<p>Increase in the size of an organ or tissue due to an increase in the size of the cells.</p> Signup and view all the answers

What is anaplasia?

<p>Reversal of highly differentiated cells into a less differentiated type.</p> Signup and view all the answers

What is oral pathology?

<p>A branch of systemic pathology that deals with diseases affecting soft and hard oral tissues, including teeth</p> Signup and view all the answers

What is metaplasia?

<p>Reversible replacement of one differentiated cell type with another mature differentiated cell type.</p> Signup and view all the answers

What is atrophy?

<p>Decrease in the size of an organ or tissue after complete formation.</p> Signup and view all the answers

What is hyperkeratosis?

<p>Thickening of the stratum corneum.</p> Signup and view all the answers

What is pedunculated?

<p>Attached by a stemlike or stalk base similar to that of a mushroom.</p> Signup and view all the answers

What is diffuse?

<p>Describes a lesion with borders that are not well defined, making it impossible to detect the exact parameters of the lesion.</p> Signup and view all the answers

What is Fordyce granules?

<p>An ectopic condition in which sebaceous glands develop in the oral mucosa</p> Signup and view all the answers

What is the typical location of Fordyce granules?

<p>Symmetrically located most frequently in the buccal mucosa in the molar region</p> Signup and view all the answers

What is White Spongy Naevus?

<p>A hereditary condition of the oral mucosa, which is sometimes congenital</p> Signup and view all the answers

What is the characteristic appearance of White Spongy Naevus?

<p>Grayish-white spongy areas of the oral mucosa with folds, soft upon palpation</p> Signup and view all the answers

What are Bohn's nodules?

<p>Small, discrete, whitish swellings occurring in the gingivae of infants</p> Signup and view all the answers

What is the location of Bohn's nodules?

<p>On the alveolar ridge, more commonly on the maxillary than mandibular</p> Signup and view all the answers

What is Aglossia?

<p>Complete absence of the tongue</p> Signup and view all the answers

What is the characteristic histopathology of Fordyce granules?

<p>Normal sebaceous glands without hair follicles</p> Signup and view all the answers

What does 'hard' refer to in terms of a physical property?

<p>Not easily broken or bent</p> Signup and view all the answers

What is metastasis?

<p>The spread of a tumor or cancer to distant parts of the body from its original site</p> Signup and view all the answers

What is a mutation?

<p>A relatively permanent change in hereditary material involving either a physical change in chromosome relations or a biochemical change in the codons that make up genes</p> Signup and view all the answers

What is asymmetric overgrowth of one or more body parts?

<p>It represents a hyperplasia of the tissues rather than a hypertrophy</p> Signup and view all the answers

What is an oblique facial cleft?

<p>A developmental cleft that starts from the inner canthus of the eye to the ala of the nose or upper lip</p> Signup and view all the answers

What is a transverse facial cleft?

<p>A cleft running from the angle of the mouth towards the ear</p> Signup and view all the answers

What is facial hemi-hypertrophy or –atrophy?

<p>A condition where one side of the face is larger or smaller than the other</p> Signup and view all the answers

What is the sex predilection of facial hemi-hypertrophy or –atrophy?

<p>2:1 in females</p> Signup and view all the answers

What is the characteristic feature of geographic tongue?

<p>Multiple, irregular or circular, depapillated areas with fungiform papillae persisting as small elevated red dots</p> Signup and view all the answers

What is the possible etiology of geographic tongue?

<p>Emotional stress, immunosuppression, and Candidal infection</p> Signup and view all the answers

What is the histological feature of geographic tongue?

<p>Loss of filliform papillae, hyperparakeratosis, acanthosis, and presence of polymorphs and lymphocytes within the epithelium</p> Signup and view all the answers

What is the origin of lingual thyroid nodule?

<p>Follicles of thyroid tissue that failed to migrate to its predestined position or detached remnants left behind</p> Signup and view all the answers

Where is the lingual thyroid nodule typically located?

<p>In or near the tongue base, often near the foramen caecum</p> Signup and view all the answers

What is the suggested relationship between hormonal factors and lingual thyroid nodule?

<p>It is more common in females during puberty, adolescence, pregnancy, or menopause</p> Signup and view all the answers

What is the appearance of the lingual thyroid nodule?

<p>A nodular, smooth surfaced mass</p> Signup and view all the answers

What is the characteristic feature of hyaline degeneration of muscles?

<p>Lymphocytic infiltration within the connective tissue and numerous blood vessels and lymphatics</p> Signup and view all the answers

Study Notes

Classification of Pathology

  • General pathology: Deals with basic alterations and general characteristics of major disease categories
  • Systemic pathology: Deals with diseases affecting specific organs or systems
  • Oral pathology: A branch of systemic pathology that deals with diseases affecting the soft and hard oral tissues, including the teeth

Disease and Etiology

  • Disease: An abnormal alteration of structure or function in any part of the body
  • Etiology: The study of the cause of a disease
  • Importance of etiology: Remains the backbone of disease diagnosis, understanding the nature of diseases, and treatment of diseases
  • Etiologic agent: The factor responsible for lesions or a disease state
  • Types of causes of disease:
    • Predisposing causes: Factors that make an individual more susceptible to a disease
    • Exciting causes: Factors directly responsible for a disease

Classification of Diseases

  • Developmental: Genetic or congenital
  • Acquired: Genetic feature resulted from an extrinsic factor during development
  • Inflammatory: Trauma, infections, immune, etc.
  • Neoplasm: Abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissue
  • Hypertrophy: Increase in the size of an organ or tissue due to an increase in the size of the cells
  • Hyperplasia: Increase in the size of an organ or tissue due to an increase in the number of cells

Index for Scientific Terms

  • Anaplasia: Reversal of highly differentiated cells into a less differentiated type
  • Metaplasis: Reversible replacement of one differentiated cell type with another mature differentiated cell type
  • Aplasia: Complete failure of formation of an organ or tissue
  • Hypoplasia: Incomplete development of an organ or tissue
  • Atrophy: Decrease in the size of an organ or tissue after complete formation
  • Hyperkeratosis: Thickening of the stratum corneum
  • Acanthosis: Thickening or widening of the stratum spinosum
  • Spongiosis: Intercellular edema
  • Acantholysis: Separation of cells in stratum spinosum resulting in intraepithelial split
  • Pedunculated: Attached by a stemlike or stalk base
  • Sessile: Describing the base of a lesion that is flat or broad instead of stemlike
  • Diffuse: Describing a lesion with borders that are not well defined
  • Exophytic:
  • Firm: Strongly felt and unlikely to change
  • Cheesy: Like cheese in consistency
  • Hard: Not easily broken or bent
  • Metastasis: Spread of a tumor or cancer to distant parts of the body from its original site
  • Mutation: Relatively permanent change in hereditary material

Developmental Anomalies Associated with Asymmetric Growth

  • Asymmetric overgrowth of one or more body parts, mostly represents a hyperplasia of the tissues rather than a hypertrophy
  • Etiology: Obscure, but various theories include vascular or lymphatic abnormalities, CNS disturbances, endocrine dysfunction, aberrant twinning mechanisms, and chromosomal anomalies

Developmental Disturbances of the Face

  • Orofacial clefts:
    • Oblique facial cleft: Developmental cleft starting from the inner canthus of the eye to the ala of the nose or upper lip
    • Transverse facial cleft: Cleft running from the angle of the mouth towards the ear
  • Facial hemi-hypertrophy or atrophy:
    • 2:1 in females, more on the right side, often noted at birth or later in childhood
    • 20% are mentally retarded

Developmental Anomalies of the Oral Mucosa

  • Fordyce granules:
    • Ectopic condition in which sebaceous glands develop in the oral mucosa
    • Clinical appearance: Single or multiple pinhead-sized spots appear symmetrically located most frequently in the buccal mucosa
    • Histopathology: Normal sebaceous glands without hair follicles
  • White spongy naevus (white folded gingivostomatitis):
    • Hamartoma in skin or mucous membrane
    • Clinical appearance: Grayish-white spongy areas of the oral mucosa with folds and it is soft upon palpation
    • Histopathology: Prickle cell layer shows acanthosis with inter- and intracellular edema or vacuolation giving the basket-weave appearance with surface hyperkeratosis
  • Bohn's nodules:
    • Small, discrete, whitish swellings occurring in the gingivae of infants
    • Represent small cysts that arise from degeneration of remnants of the dental lamina
    • Are keratin cysts derived from remnants of odontogenic epithelium over the dental lamina or may be remnants of minor salivary glands

Developmental Anomalies of the Tongue

  • Aglossia: Complete absence of the tongue; very rare, may be associated with agnathia
  • Geographic tongue (benign migratory glossitis):
    • Unknown etiology, may be related to emotional stress, immunosuppression, and Candidal infection
    • Clinical appearance: Multiple, irregular or circular, depapillated areas, fungiform papillae persist as small elevated red dots
    • Histologically: Filliform papillae are lost, at the margins hyperparakeratosis and some acanthosis, polymorphs and lymphocytes are seen within the epithelium, producing epithelial degeneration and microabscess formation, special stains reveal Candidal hyphae within the epithelium

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Learn about the basics of pathology, including classification, general pathology, and systemic pathology. Understand what constitutes a disease and how it affects the body.

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