Depression and Bipolar Disorders Overview
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Questions and Answers

Which symptom is characteristic of mania in bipolar disorder?

  • Increased need for sleep
  • Feeling excessively tired all the time
  • Experiencing vivid nightmares
  • Decreased need for sleep (correct)

What is a key feature that distinguishes Bipolar 1 from Bipolar 2 disorder?

  • No depressive episodes in Bipolar 1
  • Presence of at least 1 hypomanic episode
  • Excessive involvement in risk-free activities in Bipolar 2
  • Presence of at least 1 manic episode (correct)

What is a symptom that distinguishes hypomania from mania?

  • Severe hallucinations
  • Psychotic features
  • Excessive risk-taking behavior
  • Less severe impairment in daily functioning (correct)

Which condition must be excluded when diagnosing Bipolar Disorder 1?

<p>Hyperthyroidism (C)</p> Signup and view all the answers

What is a common symptom observed in individuals experiencing manic psychosis?

<p>Marked disorientation and confusion (B)</p> Signup and view all the answers

Which criterion in the DSM-5 must be satisfied for a diagnosis of Bipolar Disorder?

<p>At least 1 episode of mania/hypomania lasting for at least 4 consecutive days (D)</p> Signup and view all the answers

What is the predicted rank of Major Depressive Disorder (MDD) as a leading cause of disability worldwide by 2030 according to the World Health Organization (WHO)?

<p>The 2nd leading cause (C)</p> Signup and view all the answers

Which of the following is NOT listed as a risk factor for Major Depressive Disorder (MDD)?

<p>Genetic predisposition to anxiety disorders (A)</p> Signup and view all the answers

Which of the following cognitive symptoms is NOT listed as a clinical feature of Major Depressive Disorder (MDD)?

<p>Impaired problem-solving ability (D)</p> Signup and view all the answers

What is the minimum duration of symptoms required for a diagnosis of Major Depressive Disorder (MDD) according to the DSM-5 criteria?

<p>2 weeks (D)</p> Signup and view all the answers

Which receptor, when blocked, would cause dry mouth and constipation?

<p>M receptors (D)</p> Signup and view all the answers

What adverse effect is expected from blocking alpha-1 receptors on blood vessels?

<p>Vasodilation leading to edema in the brain, kidney, and GI tract (A)</p> Signup and view all the answers

Which receptors, when blocked, can inhibit feeding and disrupt the sleep-wake cycle?

<p>H1 receptors (C)</p> Signup and view all the answers

Which of the following is NOT a common adverse effect associated with blocking M receptors by tricyclic antidepressants (TCAs)?

<p>Weight gain (D)</p> Signup and view all the answers

What is the main mechanism behind life-threatening cardiac arrhythmias in TCA overdose?

<p>Blocking of Na+ channels in myocardial cells (A)</p> Signup and view all the answers

Which receptor, when blocked by TCAs, is responsible for their sexual dysfunction adverse effect?

<p>5-HT2a receptors (B)</p> Signup and view all the answers

Which of the following is NOT a core feature of a delusion?

<p>The person recognizes that the belief is irrational and not based in reality (A)</p> Signup and view all the answers

Which neurotransmitter system has been implicated in the pathophysiology of major depressive disorder based on the monoamine hypothesis?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a distinguishing feature of bipolar I disorder compared to bipolar II disorder?

<p>Presence of manic episodes (C)</p> Signup and view all the answers

According to the neurotrophic hypothesis, which of the following is proposed to contribute to the pathophysiology of major depressive disorder?

<p>Decreased levels of brain-derived neurotrophic factor (BDNF) (A)</p> Signup and view all the answers

Which of the following is a proposed mechanism of action for selective serotonin reuptake inhibitors (SSRIs), a common class of antidepressant medications?

<p>Inhibition of serotonin reuptake, increasing synaptic serotonin levels (C)</p> Signup and view all the answers

Which of the following is a proposed mechanism underlying the metabolic imbalance associated with bipolar disorder?

<p>Increased glycolysis and reduced oxidative phosphorylation (A)</p> Signup and view all the answers

What is the primary mechanism of action for selective serotonin reuptake inhibitors (SSRIs)?

<p>Inhibiting the reuptake of serotonin in the synaptic cleft (C)</p> Signup and view all the answers

How do serotonin-norepinephrine reuptake inhibitors (SNRIs) differ from tricyclic antidepressants (TCAs) in terms of receptor blockade?

<p>SNRIs have weaker alpha-1, histamine, and muscarinic receptor blockades than TCAs (B)</p> Signup and view all the answers

Which of the following statements about venlafaxine, an SNRI, is correct?

<p>It weakly inhibits dopamine reuptake in addition to serotonin and norepinephrine reuptake (D)</p> Signup and view all the answers

What is the role of serotonin in the therapeutic mechanism of antidepressants?

<p>Serotonin is responsible for regulating mood and emotional states (D)</p> Signup and view all the answers

Which of the following adverse effects is typically more pronounced with TCAs compared to SSRIs?

<p>Sedation and anticholinergic effects (A)</p> Signup and view all the answers

What is a potential advantage of SSRIs over TCAs in terms of adverse effects?

<p>Lower risk of weight gain over time (D)</p> Signup and view all the answers

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