Pathogenesis of Endometrial Cancer
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Questions and Answers

What is the most common symptom of hyperplasia?

  • Vaginal discharge
  • Pelvic pain
  • Abnormal uterine contractions
  • Heavy bleeding during menstrual period (correct)

    • What is the consequence of PTEN tumor suppressor gene inactivation?

  • AKT phosphorylation decrease
  • Inhibition of protein synthesis
  • AKT phosphorylation increase (correct)
  • Stimulation of apoptosis

    • What is the characteristic of the stroma in simple hyperplasia?

  • Low cellular density
  • Fibrotic changes
  • High mitotic activity
  • Very cellular with spindle-shaped cells (correct)

    • What is the risk of progression to adenocarcinoma in simple hyperplasia?

    <p>1%</p> Signup and view all the answers

    What is the characteristic of the glands in complex hyperplasia?

    <p>Crowded and branched without atypia</p> Signup and view all the answers

    What is the effect of estrogen stimulation on the endometrium?

    <p>Stimulates epithelial growth</p> Signup and view all the answers

    What is the characteristic of the epithelial cells in simple hyperplasia?

    <p>Flattened without atypia</p> Signup and view all the answers

    What is the gross appearance of the uterus in hyperplasia?

    <p>Enlarged with thickened polypoid endometrium</p> Signup and view all the answers

    What is the characteristic of the ovarian changes in hyperplasia?

    <p>Follicular cysts</p> Signup and view all the answers

    What is the gland-to-stroma ratio in simple hyperplasia?

    <p>Mildly increased</p> Signup and view all the answers

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