Pathogenesis of Endometrial Cancer

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10 Questions

What is the most common symptom of hyperplasia?

Heavy bleeding during menstrual period

What is the consequence of PTEN tumor suppressor gene inactivation?

AKT phosphorylation increase

What is the characteristic of the stroma in simple hyperplasia?

Very cellular with spindle-shaped cells

What is the risk of progression to adenocarcinoma in simple hyperplasia?

1%

What is the characteristic of the glands in complex hyperplasia?

Crowded and branched without atypia

What is the effect of estrogen stimulation on the endometrium?

Stimulates epithelial growth

What is the characteristic of the epithelial cells in simple hyperplasia?

Flattened without atypia

What is the gross appearance of the uterus in hyperplasia?

Enlarged with thickened polypoid endometrium

What is the characteristic of the ovarian changes in hyperplasia?

Follicular cysts

What is the gland-to-stroma ratio in simple hyperplasia?

Mildly increased

Learn about the clinical settings and risk factors of endometrial cancer, including estrogen excess, nulliparity, obesity, and more. Discover the difference between endometrioid and serous types of endometrial carcinoma.

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