Endometrial Hyperplasia and Cancer Overview

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Questions and Answers

What is a significant factor affecting survival rates for endometrial cancer?

  • Stage at diagnosis (correct)
  • Type of endometrial hyperplasia present
  • Age of the patient at diagnosis
  • Type of treatment administered

Which of the following is NOT a screening method for endometrial cancer?

  • Cervical brush sample
  • PET scan (correct)
  • Blood sample
  • Endometrial lavage and brushings

What should be considered when managing endometrial hyperplasia in women wishing to conceive?

  • Immediate surgical intervention
  • Chemotherapy as the primary treatment
  • Hormonal therapy without monitoring
  • Conservative treatment options (correct)

What is the approximate number of new cases of endometrial cancer reported annually in the UK?

<p>9000 cases (B)</p> Signup and view all the answers

Which of the following factors is critical in deciding conservative treatment for endometrial cancer?

<p>Stage of cancer at diagnosis (A)</p> Signup and view all the answers

Which histological type is classified as aggressive in the revised 2023 FIGO update?

<p>Carcinosarcoma (A)</p> Signup and view all the answers

What is the prognosis associated with POLEmut molecular classification?

<p>Excellent prognosis (C)</p> Signup and view all the answers

Which histological grade corresponds to a solid non-glandular component of 50%?

<p>Grade 02 (A)</p> Signup and view all the answers

What type of cancer is classified under 'Unusual types' in the histological types?

<p>Gastro-intestinal mucinous type (B)</p> Signup and view all the answers

Which grade specifically indicates a high-grade endometrioid cancer?

<p>Grade 03 (D)</p> Signup and view all the answers

What is the prognosis of Mismatch Repair Defect (MMRd) classification?

<p>Intermediate prognosis (D)</p> Signup and view all the answers

Which of the following is NOT a part of aggressive histological types in endometrial cancer?

<p>Low-grade endometrioid (G1) (A)</p> Signup and view all the answers

Which classification indicates a poor prognosis?

<p>P53abn (D)</p> Signup and view all the answers

Flashcards

Endometrial hyperplasia

Abnormal thickening of the lining of the uterus (endometrium).

Endometrial cancer

Cancer that develops in the lining of the uterus.

Endometrial hyperplasia classification

Categorizing the different types of endometrial hyperplasia based on features.

Endometrial hyperplasia diagnosis

The process of determining if endometrial hyperplasia is present.

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Management of hyperplasia (no atypia)

Treatment approaches for endometrial hyperplasia without atypical cells.

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Hyperplasia (no atypia) treatment duration

Length of treatment and follow-up for hyperplasia without unusual cells.

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Surgical management (hyperplasia no atypia)

Surgical options for endometrial hyperplasia that lacks unusual characteristics.

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Atypical hyperplasia

A more severe form of endometrial hyperplasia with potential cancer risk.

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Conception and hyperplasia

Strategies for managing endometrial hyperplasia in women wishing to conceive.

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Endometrial cancer risk factors

Factors that increase the chance of developing endometrial cancer.

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Endometrial cancer survival rates

The likelihood of survival depending on the stage of the cancer at diagnosis.

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Endometrial cancer screening

Methods for detecting endometrial cancer in its early stages.

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Red flags (cancer)

Symptoms or signs that suggest potential endometrial cancer.

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Endometrial Cancer Grades

Classifies endometrial cancer based on the percentage of solid, non-glandular components in the tissue sample.

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Grade 3 Endometroid Cancer

A type of endometrial cancer with varied clinical, prognostic, and molecular features; most benefit from molecular profiling.

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POLE Mutation

A genetic mutation linked to endometrial cancer with excellent prognosis and responsiveness to immunotherapy.

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P53 Abnormality

A genetic abnormality in endometrial cancer associated with a poor prognosis.

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Mismatch Repair Defect (MMRd)

A genetic deficiency associated with endometrial cancer and an intermediate prognosis.

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Non-Specific Molecular Profile (NSMP)

A molecular profile in endometrial cancer with an intermediate prognosis in the lack of other specific findings.

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Histology

The study of tissue samples for cancer diagnostics and classification, in this context of endometrial cancer.

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High-grade endometroid

A type of endometrial cancer with a more aggressive form that is clinically, prognostically, and also molecularly heterogeneous.

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Low-grade endometroid

A less aggressive type of endometrial cancer.

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Study Notes

Endometrial Cancer Survival Rates

  • Stage at diagnosis is a crucial determinant of survival rates for endometrial cancer.
  • Early-stage detection generally correlates with higher survival rates.

Endometrial Cancer Screening

  • Transvaginal ultrasound is not a conventional screening method for endometrial cancer.

Endometrial Hyperplasia Management

  • When managing endometrial hyperplasia in women wanting to conceive, individual factors need careful consideration.
  • Patient age, the severity of hyperplasia, and reproductive goals are paramount in decision-making.
  • Balancing the desire to conceive with the potential risks of endometrial cancer is crucial.

Endometrial Cancer Incidence in the UK

  • Approximately 9,000 new cases of endometrial cancer are diagnosed annually in the UK.

Conservative Treatment for Endometrial Cancer

  • The tumor's grade, stage, and patient's overall health are key factors in deciding upon conservative treatment options for endometrial cancer.
  • Age, desire for future fertility, and risk of recurrence all influence the choice of treatment.

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