6 Questions
What is unique about the DNA of Parvovirus B19?
It is single-stranded
How is Parvovirus B19 primarily transmitted?
Through respiratory droplets
What is the usual progression of the rash in Erythema infectiosum?
It starts on the face and moves downward
What is the potential consequence for a fetus if the mother is infected with Parvovirus B19 during pregnancy?
The fetus may develop hydrops fetalis
Which group of people is at risk for developing aplastic anemia if infected with Parvovirus B19?
People with sickle cell disease
What is a common misdiagnosis of Erythema infectiosum?
Rubella
Study Notes
Parvovirus B19 Characteristics
- Parvovirus B19 is a DNA virus.
- It is the smallest virus.
- It is a single-stranded virus.
Transmission and Infection
- Transmitted via respiratory droplets.
- Can be transferred from mother to fetus.
Symptoms and Effects
- Causes slapped cheek disease or fifth disease (erythema infectiosum).
- Characterized by a low-grade fever that lasts a week, followed by a lacy reticular pattern that spreads down the body.
- In adults, it can cause joint pain, arthritis, and soreness.
- In sickle cell patients, it can lead to aplastic anemia.
Pregnancy and Fetal Effects
- If a baby in utero is exposed to parvovirus, the consequences can be severe and may lead to hydrops fetalis.
- Hydrops fetalis is characterized by massive edema and can result in fetal demise.
Virus Replication and Tropism
- The virus initiates replication in the nasopharynx or upper respiratory tract.
- The virus has a tropism for actively replicating erythroid progenitors, resulting in cell lysis.
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