Parvovirus B19
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Questions and Answers

What is unique about the DNA of Parvovirus B19?

  • It is circular
  • It is single-stranded (correct)
  • It is double-stranded
  • It is linear
  • How is Parvovirus B19 primarily transmitted?

  • Through respiratory droplets (correct)
  • Through contaminated food and water
  • Through vectors such as mosquitoes
  • Through contact with contaminated surfaces
  • What is the usual progression of the rash in Erythema infectiosum?

  • It starts on the trunk and moves outward
  • It starts on the face and moves downward (correct)
  • It starts on the chest and moves outward
  • It starts on the extremities and moves inward
  • What is the potential consequence for a fetus if the mother is infected with Parvovirus B19 during pregnancy?

    <p>The fetus may develop hydrops fetalis</p> Signup and view all the answers

    Which group of people is at risk for developing aplastic anemia if infected with Parvovirus B19?

    <p>People with sickle cell disease</p> Signup and view all the answers

    What is a common misdiagnosis of Erythema infectiosum?

    <p>Rubella</p> Signup and view all the answers

    Study Notes

    Parvovirus B19 Characteristics

    • Parvovirus B19 is a DNA virus.
    • It is the smallest virus.
    • It is a single-stranded virus.

    Transmission and Infection

    • Transmitted via respiratory droplets.
    • Can be transferred from mother to fetus.

    Symptoms and Effects

    • Causes slapped cheek disease or fifth disease (erythema infectiosum).
    • Characterized by a low-grade fever that lasts a week, followed by a lacy reticular pattern that spreads down the body.
    • In adults, it can cause joint pain, arthritis, and soreness.
    • In sickle cell patients, it can lead to aplastic anemia.

    Pregnancy and Fetal Effects

    • If a baby in utero is exposed to parvovirus, the consequences can be severe and may lead to hydrops fetalis.
    • Hydrops fetalis is characterized by massive edema and can result in fetal demise.

    Virus Replication and Tropism

    • The virus initiates replication in the nasopharynx or upper respiratory tract.
    • The virus has a tropism for actively replicating erythroid progenitors, resulting in cell lysis.

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