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Questions and Answers
Which of the following is NOT a method used to determine particle size?
Which of the following is NOT a method used to determine particle size?
What is the key factor in determining the most suitable method for particle size analysis?
What is the key factor in determining the most suitable method for particle size analysis?
Which method is the most precise for presenting particle size analysis data?
Which method is the most precise for presenting particle size analysis data?
What is the formula for calculating the mean diameter (d) of a particle size range using the sieving method?
What is the formula for calculating the mean diameter (d) of a particle size range using the sieving method?
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What does the % Undersize on a histogram represent?
What does the % Undersize on a histogram represent?
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What are the advantages of using the sieving method for particle size analysis?
What are the advantages of using the sieving method for particle size analysis?
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What is the minimum number of sieves required to perform particle size analysis using the sieving method?
What is the minimum number of sieves required to perform particle size analysis using the sieving method?
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What is the typical range of particle sizes that can be measured using the sieving method?
What is the typical range of particle sizes that can be measured using the sieving method?
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What is the term used to describe the distribution of particles in a powder bed between the smallest and largest particles?
What is the term used to describe the distribution of particles in a powder bed between the smallest and largest particles?
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Which of the following is NOT a factor that influences the accuracy of the sieving method?
Which of the following is NOT a factor that influences the accuracy of the sieving method?
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What type of motion is generally considered the most efficient for sieving?
What type of motion is generally considered the most efficient for sieving?
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What is the maximum particle size that is typically considered to be a powder?
What is the maximum particle size that is typically considered to be a powder?
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How does particle size distribution affect the properties of a pharmaceutical product?
How does particle size distribution affect the properties of a pharmaceutical product?
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Flashcards
Particle Size Analysis
Particle Size Analysis
A method used to determine the distribution of particle sizes in a sample.
Sieving Method
Sieving Method
A technique using mesh screens to separate particles based on size.
% Oversize
% Oversize
The percentage of particles larger than a specified size.
Mean Diameter (d)
Mean Diameter (d)
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Distribution Curve
Distribution Curve
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Advantages of Sieving
Advantages of Sieving
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Sieve Number
Sieve Number
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Particle Size Distribution
Particle Size Distribution
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Factors Influencing Sieving
Factors Influencing Sieving
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Types of Motion in Sieving
Types of Motion in Sieving
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Mean Particle Size
Mean Particle Size
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Importance of Particle Size Analysis
Importance of Particle Size Analysis
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Study Notes
Particle Size Analysis by Sieving Method
- Sieving is a simple, inexpensive, rapid, and reproducible method for particle size analysis.
- Sieves are composed of screens and frames. Sieve size is measured in mesh (openings per linear inch) or micrometers.
- To analyze, a set of sieves (at least 5) and a collector are required.
- Particles are placed on the top sieve of a stack.
- The stack is then shaken.
- The weight of the material resting on each sieve is measured.
- This data is used to calculate the percentage of particles within specific size ranges.
Factors Influencing Sieving
- Factors influencing the sieving method include:
- Sample weight
- Duration and type of shaking/motion
- Type of motion during sieving (vibratory, side tap, bottom pat, rotary). Vibratory motion is usually the most efficient.
- Standardized motion is crucial for reproducible results.
Introduction to Powder and Particle Size Distribution
- Powder is a heterogeneous mixture of particles with various shapes and sizes.
- Particle size analysis determines the distribution of particle sizes in a powder bed.
- Particle sizes are usually less than 1000 micrometers.
- Particle size analysis is a process of fractionation, determining the percentage and mean particle size for each fraction.
Importance of Particle Size Analysis
- Particle size analysis is vital for analyzing and understanding material behavior.
- Particle size distribution influences:
- Processability
- Disintegration time
- Dissolution rates
- Bioavailability
- Stability of manufactured products.
Particle Size Analysis Techniques
- Several methods can be used to analyze particle size including:
- Sieving
- Image analysis
- Coulter counter method
- Sedimentation method
- Laser diffraction method
- The choice of method depends on the material and required information.
Representative Samples in Particle size Analysis:
- A representative sample is needed for accurate analysis.
- The sample should accurately reflect the entire bulk powder.
- The sample selected must be truly representative of the whole material being studied.
Graphical Representation of Data
- The results of particle size analysis can be presented graphically:
- Distribution curves
- Histograms
- Graphical representations allow easier visualization of particle size distribution.
- The percentage of oversize (particles larger than specified range) and undersize (smaller than specified range), mean particle size, and distribution curves are determined and shown graphically.
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Description
Explore the principles of particle size analysis using the sieving method. Understand the factors that influence the accuracy of results, and learn how to properly conduct sieving for effective analysis of powder and particle size distribution. This quiz covers essential concepts and techniques related to sieve operation.
