16 Questions
What is the primary neurotransmitter of the Cholinergic Neuron?
Acetylcholine
Where are Muscarinic Receptors primarily found?
Neuro-effector junction of the Parasympathetic nervous system
What is the function of M2 receptors in the heart?
Decrease heart rate and force of contraction
What is the result of Acetylcholine binding to Muscarinic Receptors?
Increased intracellular [Ca] and activation of 2nd messenger
Which of the following is associated with Nicotinic Receptors?
CNS and Adrenal medulla
What is the location of M4 receptors?
Basal ganglia, amygdala, hippocampus
What is the primary effect of acetylcholine on the heart rate?
Decrease heart rate
What is the primary therapeutic use of pilocarpine?
Treatment of open-angle glaucoma
What is the mechanism of action of indirect acting agents?
Inhibition of acetylcholinesterase
What is the therapeutic use of physostigmine?
Treatment of atony of intestines and bladder
What is the duration of action of pyridostigmine?
3-6 hours
What is the primary adverse effect of neostigmine?
Convulsions
What is the therapeutic use of tacrine?
Treatment of Alzheimer's disease
What is the effect of echothiophate on acetylcholinesterase?
Irreversible inhibition
What is the primary use of pralidoxime?
Treatment of organo-phosphate poisoning
What is the common side effect of muscarinic agonists?
Diarrhea
Explore the characteristics of cholinergic agonists in the parasympathetic system, including acetylcholine synthesis, storage, release, binding, and degradation. Learn about muscarinic receptors and their role in the nervous system.
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