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Parasympathetic System: Cholinergic Agonists

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Parasympathetic System: Cholinergic Agonists

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Questions and Answers

What is the primary neurotransmitter of the Cholinergic Neuron?

Dopamine

Acetylcholine (correct)

Serotonin

GABA

Where are Muscarinic Receptors primarily found?

Neuro-effector junction of the Parasympathetic nervous system (correct)

Somatic nervous system

Sensory organs

Sympathetic nervous system

What is the function of M2 receptors in the heart?

Stimulate the release of adrenaline

Inhibit the release of acetylcholine

Increase heart rate and force of contraction

Decrease heart rate and force of contraction (correct)

What is the result of Acetylcholine binding to Muscarinic Receptors?

Increased intracellular [Ca] and activation of 2nd messenger Signup and view all the answers

Which of the following is associated with Nicotinic Receptors?

CNS and Adrenal medulla Signup and view all the answers

What is the location of M4 receptors?

Basal ganglia, amygdala, hippocampus Signup and view all the answers

What is the primary effect of acetylcholine on the heart rate?

Decrease heart rate Signup and view all the answers

What is the primary therapeutic use of pilocarpine?

Treatment of open-angle glaucoma Signup and view all the answers

What is the mechanism of action of indirect acting agents?

Inhibition of acetylcholinesterase Signup and view all the answers

What is the therapeutic use of physostigmine?

Treatment of atony of intestines and bladder Signup and view all the answers

What is the duration of action of pyridostigmine?

3-6 hours Signup and view all the answers

What is the primary adverse effect of neostigmine?

Convulsions Signup and view all the answers

What is the therapeutic use of tacrine?

Treatment of Alzheimer's disease Signup and view all the answers

What is the effect of echothiophate on acetylcholinesterase?

Irreversible inhibition Signup and view all the answers

What is the primary use of pralidoxime?

Treatment of organo-phosphate poisoning Signup and view all the answers

What is the common side effect of muscarinic agonists?

Diarrhea Signup and view all the answers