Parasympathetic System: Cholinergic Agonists

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Questions and Answers

What is the primary neurotransmitter of the Cholinergic Neuron?

  • Dopamine
  • Acetylcholine (correct)
  • Serotonin
  • GABA

Where are Muscarinic Receptors primarily found?

  • Neuro-effector junction of the Parasympathetic nervous system (correct)
  • Somatic nervous system
  • Sensory organs
  • Sympathetic nervous system

What is the function of M2 receptors in the heart?

  • Stimulate the release of adrenaline
  • Inhibit the release of acetylcholine
  • Increase heart rate and force of contraction
  • Decrease heart rate and force of contraction (correct)

What is the result of Acetylcholine binding to Muscarinic Receptors?

<p>Increased intracellular [Ca] and activation of 2nd messenger (B)</p> Signup and view all the answers

Which of the following is associated with Nicotinic Receptors?

<p>CNS and Adrenal medulla (B)</p> Signup and view all the answers

What is the location of M4 receptors?

<p>Basal ganglia, amygdala, hippocampus (A)</p> Signup and view all the answers

What is the primary effect of acetylcholine on the heart rate?

<p>Decrease heart rate (C)</p> Signup and view all the answers

What is the primary therapeutic use of pilocarpine?

<p>Treatment of open-angle glaucoma (B)</p> Signup and view all the answers

What is the mechanism of action of indirect acting agents?

<p>Inhibition of acetylcholinesterase (C)</p> Signup and view all the answers

What is the therapeutic use of physostigmine?

<p>Treatment of atony of intestines and bladder (B)</p> Signup and view all the answers

What is the duration of action of pyridostigmine?

<p>3-6 hours (A)</p> Signup and view all the answers

What is the primary adverse effect of neostigmine?

<p>Convulsions (A)</p> Signup and view all the answers

What is the therapeutic use of tacrine?

<p>Treatment of Alzheimer's disease (C)</p> Signup and view all the answers

What is the effect of echothiophate on acetylcholinesterase?

<p>Irreversible inhibition (B)</p> Signup and view all the answers

What is the primary use of pralidoxime?

<p>Treatment of organo-phosphate poisoning (B)</p> Signup and view all the answers

What is the common side effect of muscarinic agonists?

<p>Diarrhea (D)</p> Signup and view all the answers

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