Paramedic Drugs: Promethazine Flashcards

Questions and Answers

What is the class of Phenergan?

Phenothiazine

Antihistamine

Antiemetic

All of the above (correct)

What is the mechanism of action (MOA) of Phenergan?

H-1 receptor antagonist; blocks the action of histamine; possesses sedative, anti-motion, antiemetic and anticholinergic activity; potentiates the effects of narcotics to induce analgesia.

List some indications for Phenergan.

Nausea/vomiting, motion sickness, sedation for patients in labor, potentiation of the analgesia effects of narcotics.

What are some contraindications for using Phenergan?

Coma, CNS depression from alcohol, barbiturates, or narcotics, Reye syndrome, lower respiratory symptoms (asthma). Signup and view all the answers

What are some adverse effects of Phenergan?

Headache, dizziness, drowsiness, confusion, restlessness, wheezing, chest tightness, thickening of bronchial secretions, palpitations, bradycardia, reflex tachycardia, OT prolongation, postural hypotension, diarrhea, nausea, vomiting. Signup and view all the answers

What are the drug interactions associated with Phenergan?

Additive with other CNS depressants, increased extrapyramidal effects with MAOIs. Signup and view all the answers

For adults, Phenergan is administered at a dosage of _____ mg IV or deep IM.

12.5-25 Signup and view all the answers

For pediatric patients older than 2 years, the dosage of Phenergan is _____ mg/kg deep IM.

0.25-0.5 Signup and view all the answers

What is the duration of action of Phenergan?

ONSET: IV immediate, PEAK EFFECT: 30-60 min, DURATION: 4-6 hrs. Signup and view all the answers

Study Notes

Phenergan (Promethazine Hydrochloride) Overview

Classifies as a phenothiazine, antihistamine, and antiemetic.
Primarily used for its ability to alleviate nausea, vomiting, and to manage motion sickness.

Mechanism of Action

Functions as an H-1 receptor antagonist, inhibiting the action of histamine.
Exhibits sedative, anti-motion, antiemetic, and anticholinergic properties.
Enhances narcotic analgesia effects.

Indications

Effective for nausea and vomiting relief.
Used for prevention of motion sickness.
Provides sedation for patients undergoing labor.
Indicated for potententiate analgesia from narcotics.

Contraindications

Should not be used in individuals in a coma.
Avoid in those with CNS depression due to alcohol, barbiturates, or narcotics.
Contraindicated in patients with Reye's syndrome or lower respiratory issues, such as asthma.

Adverse Effects

Commonly causes headache, dizziness, drowsiness, and confusion.
Can lead to restlessness, wheezing, chest tightness, and thickened bronchial secretions.
May result in palpations, bradycardia, reflex tachycardia, and QT prolongation.
Other effects include postural hypotension, diarrhea, nausea, and vomiting.

Drug Interactions

Has cumulative effects when combined with other CNS depressants.
Extrapyramidal effects may be enhanced when taken with MAOIs (Monoamine Oxidase Inhibitors).

Dosage and Administration

Adult dosage: Administer 12.5-25 mg via IV, deep IM, PO, or PR routes.
Pediatric dosage: For children older than 2 years, dosage ranges from 0.25 mg to 0.5 mg/kg via deep IM.

Duration of Action

Onset: Immediate when given IV.
Peak effect: Achieved within 30-60 minutes.
Duration: Effects last approximately 4-6 hours.

Description

Test your knowledge on Promethazine Hydrochloride (Phenergan) with this set of flashcards. Covering its class, mechanism of action, and indications, this quiz is essential for paramedic students and professionals alike. Enhance your understanding of this crucial medication used in emergency care.