Papulosquamous Diseases and Pathology Quiz
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Questions and Answers

Which treatment modality is most appropriate for the patient with papulosquamous diseases as described in the text?

  • Erythromycin
  • Tacrolimus
  • Steroid
  • Phototherapy (correct)
  • Which histopathological feature is characteristic of PLEVA (pityriasis lichenoides et varioliformis acuta)?

  • More parakeratosis and epidermal destruction
  • Necrotic keratinocytes and extravasated RBCs (correct)
  • Wedge focal parakeratosis and spongiosis
  • Perivascular interface dermatitis
  • If a patient on NBUVB (narrowband UVB) therapy stops the session for 1 week, what is the recommended next step?

  • Continue
  • Increase dose (correct)
  • Decrease dose
  • Switch to a different treatment modality
  • What is the causative drug commonly associated with the development of asymptomatic nodules in a patient with rheumatoid arthritis?

    <p>Methotrexate (MTX)</p> Signup and view all the answers

    What is the most appropriate treatment for psoriasis in a child?

    <p>NBUVB therapy</p> Signup and view all the answers

    In a patient with lesions (mostly psoriasis) and without insurance coverage, which treatment modality would be most suitable?

    <p>Methotrexate (MTX)</p> Signup and view all the answers

    In a patient with dark brown multiple annular plaques, what is the most common site for this presentation?

    <p>Groin</p> Signup and view all the answers

    Which drug is most likely to cause lichenoid drug eruptions in a patient with hypertension?

    <p>Captopril</p> Signup and view all the answers

    In a patient with tiny skin colored papules on the hand resembling lichen nitidus, what is the commonest other site for this presentation?

    <p>Face</p> Signup and view all the answers

    What is the next step if a patient with rheumatoid arthritis develops asymptomatic nodules while on adalimumab treatment?

    <p>Discontinue adalimumab and start TNF alpha inhibitor</p> Signup and view all the answers

    Which treatment modality is commonly used for the management of lichen planus affecting the oral mucosa?

    <p>Tacrolimus</p> Signup and view all the answers

    In a patient with psoriatic nails and palm, what is the recommended treatment if all nails are affected?

    <p>Biological therapy</p> Signup and view all the answers

    In a female patient taking biologic treatment for 4 years with improvement, then presenting with scaly erythematous plaque and normal breast cancer investigations, what is the recommended next step?

    <p>Watch</p> Signup and view all the answers

    In a case of knee with small tiny papules as L. nitidus associated with papules on wrist, what is the HLA marker of this disease?

    <p>HLA-ABC</p> Signup and view all the answers

    In a psoriasis patient taking biologic treatment and presenting with bloody stool, which type of biologic treatment could be responsible for causing this symptom?

    <p>Secukinumab</p> Signup and view all the answers

    In a patient with bloody diarrhea after taking secukinumab, what is the next recommended investigation?

    <p>Colonoscopy</p> Signup and view all the answers

    In a 34-year-old patient with plaque psoriasis, what is the most effective treatment?

    <p>PUVA</p> Signup and view all the answers

    What is the most likely diagnosis for localized scales in the scalp beside the ear with no hair loss and erythema?

    <p>Psoriasis if pityriasis amiantacea</p> Signup and view all the answers

    In a patient with periumbilical umbilicated papules resembling molluscum and presenting with weight loss and CD4 count less than 200, what investigation is indicated?

    <p>PET scan if submandibular gland nodule present to search for primary tumor</p> Signup and view all the answers

    What is the most suitable treatment for a patient with atopic dermatitis?

    <p>NBUVB</p> Signup and view all the answers

    In a patient with renal transplantation who develops a maculopapular rash all over the body after 1 year, which virus is most likely responsible?

    <p>Polyomavirus</p> Signup and view all the answers

    What period of preconception in weeks should be considered for a case of PRP?

    <p>6 weeks</p> Signup and view all the answers

    What is the most appropriate treatment for a patient with multiple erythematous plaques, scaly papules, and no joint pain or itching for 3 months?

    <p>Acitretin</p> Signup and view all the answers

    In a female patient with controlled psoriasis on biological therapy who is diagnosed with breast cancer, what is the appropriate next step?

    <p>Watch and wait</p> Signup and view all the answers

    In a patient with eruptive skin papules on the trunk and chest with a thread-like border, which condition should be considered?

    <p>Precancerous</p> Signup and view all the answers

    What is the appropriate treatment for pityriasis rubra pilaris (PRP)?

    <p>Retinoids</p> Signup and view all the answers

    What is the histopathology typically seen in porokeratosis of Mibelli?

    <p>Parakeratosis and underlying hypogranulosis</p> Signup and view all the answers

    In a patient with scleroderma-like lesions on the hand and knee, palmoplantar hyperkeratosis, and histopathological findings suggestive of porokeratosis, what is the most likely association?

    <p>An inflammatory condition</p> Signup and view all the answers

    In a female patient with pityriasis rotunda, what neoplasm should be considered as an associated risk?

    <p>Gastric cancer</p> Signup and view all the answers

    In a female patient with Bazex syndrome (scaly plaques on hands & feet, nose & ear involvement), what neoplasm should be considered as an associated risk?

    <p>Lung cancer</p> Signup and view all the answers

    What is the most appropriate treatment for a patient with asymptomatic erythematous plaques covering >50% of body surface area and no back pain?

    <p>Narrowband UVB phototherapy</p> Signup and view all the answers

    In a patient with plaque psoriasis and congestive heart failure living 100km away from the hospital, what is the best treatment option?

    <p>Phototherapy</p> Signup and view all the answers

    In an adult female with skin-colored papules with induration on the face, trunk, and thighs (scleromyxedema), what would be the most appropriate treatment option?

    <p>Thalidomide</p> Signup and view all the answers

    In a patient with known renal failure and generalized itchy hyperpigmented lesions resembling atrophic lichen planus, what would be the most appropriate treatment?

    <p>Narrowband UVB phototherapy</p> Signup and view all the answers

    Which treatment modality is most suitable for a patient with papulosquamous diseases and no insurance coverage?

    <p>UV therapy</p> Signup and view all the answers

    In a patient with eruptive skin papules on the trunk and chest with a thread-like border, which condition should be considered?

    <p>Pityriasis rosea</p> Signup and view all the answers

    In a patient with tiny skin colored papules on the hand resembling lichen nitidus, what is the commonest other site for this presentation?

    <p>Genitalia</p> Signup and view all the answers

    What is the most common site for dark brown multiple annular plaques in a patient?

    <p>Groin</p> Signup and view all the answers

    If a patient on NBUVB (narrowband UVB) therapy stops the session for 1 week, what is the recommended next step?

    <p>Increase dose</p> Signup and view all the answers

    In a patient with rheumatoid arthritis who developed asymptomatic nodules on the elbow and knee, which drug is most likely responsible?

    <p>Methotrexate</p> Signup and view all the answers

    What is the most appropriate treatment for a patient with palmoplantar hyperkeratosis, hypopigmented lesions, and scaly erythematous papules?

    <p>Acitretin</p> Signup and view all the answers

    In a female child with asymptomatic erythematous plaques covering more than 50% of the body surface area and no back pain, what is the recommended treatment for psoriasis?

    <p>Narrowband UVB</p> Signup and view all the answers

    What is the best treatment option for a patient with plaque psoriasis and congestive heart failure living 100km away from the hospital?

    <p>Phototherapy</p> Signup and view all the answers

    What would be the most appropriate treatment for a 35-year-old adult female with skin-colored papules, induration on the face, trunk, and thighs (scleromyxodema), and no IVIG administration?

    <p>Thalidomide</p> Signup and view all the answers

    In a patient taking biologic treatment for 4 years with improvement, then presenting with scaly erythematous plaque and normal breast cancer investigations, what is the recommended next step?

    <p>MTX</p> Signup and view all the answers

    What is the HLA marker of the disease associated with small tiny papules on the knee and wrist?

    <p>HLA-ABC</p> Signup and view all the answers

    What type of keratin is associated with PPK trans gradient?

    <p>Keratin 10</p> Signup and view all the answers

    In a patient with localized scales in the scalp beside the ear, with no hair loss and erythema, what is the most likely diagnosis?

    <p>Seborrheic dermatitis</p> Signup and view all the answers

    What is the histopathology typically seen in lichen planus of the nail?

    <p>Keratinocyte necrosis</p> Signup and view all the answers

    In a patient taking biologic treatment who presents with bloody stool, which type of biologic treatment could be responsible for causing this symptom?

    <p>Secukinumab</p> Signup and view all the answers

    In a patient with renal transplantation who develops a maculopapular rash all over the body after 1 year, which virus is most likely responsible?

    <p>Polyoma</p> Signup and view all the answers

    Which epidermal differentiated keratinocytes are typically associated with K1,10?

    <p>K1,10</p> Signup and view all the answers

    What is the appropriate treatment for a patient with known renal failure and generalized itching, hyperpigmentation?

    <p>NBUVB</p> Signup and view all the answers

    In a patient with plaque psoriasis controlled on infliximab then becomes uncontrolled on infliximab, what is the next step (secondary failure)?

    <p>Shift to another biologic</p> Signup and view all the answers

    In a psoriatic patient taking biologic treatment and presenting with bloody stool, which type of biologic treatment could be responsible for causing this symptom?

    <p>Secukinumab &amp; ixekizumab &amp; brodalimumab</p> Signup and view all the answers

    In a female patient on certolizumab who becomes pregnant, what is the recommended action?

    <p>Stop</p> Signup and view all the answers

    Which treatment modality is most appropriate for the management of a patient with asymptomatic nodules on the elbow and knee caused by rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    If a patient with rheumatoid arthritis develops asymptomatic nodules on the elbow and knee, which drug is most likely responsible?

    <p>Methotrexate</p> Signup and view all the answers

    In a patient with dark brown multiple annular plaques, what is the most common site for this presentation?

    <p>Leg if pityriasis rotunda</p> Signup and view all the answers

    What is the next step if a patient on NBUVB (narrowband UVB) therapy stops the session for 1 week?

    <p>Increase dose</p> Signup and view all the answers

    A patient with rheumatoid arthritis developed asymptomatic nodules on the elbow and knee. What is the causative drug?

    <p>Methotrexate</p> Signup and view all the answers

    What would be the most appropriate treatment for a child with psoriasis?

    <p>NBUVB</p> Signup and view all the answers

    In a patient with lesions (mostly psoriasis) and without insurance coverage, which treatment modality would be most suitable?

    <p>Methotrexate</p> Signup and view all the answers

    What is the commonest other site for tiny skin colored papules as lichen nitidus, apart from the hand?

    <p>Face</p> Signup and view all the answers

    If a patient with papulosquamous diseases stopped NBUVB therapy for 1 week, what is the recommended next step?

    <p>Increase dose</p> Signup and view all the answers

    In a patient with hypertension and lichenoid drug eruptions, what is the causative drug?

    <p>Captopril</p> Signup and view all the answers

    A patient with rheumatoid arthritis developed asymptomatic nodules on the elbow and knee. What would be the most effective treatment?

    <p>Methotrexate</p> Signup and view all the answers

    What is the causative drug commonly associated with the development of asymptomatic nodules in a patient with rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    Which investigation is indicated for an old male patient with MF histopathology showing Partueir microabscess and CT scan with LN enlargement?

    <p>T cell receptor rearrangement in tissue</p> Signup and view all the answers

    What is the FDA approved drug for a case scenario of MF cd 30 positive?

    <p>Brentuximab</p> Signup and view all the answers

    In a patient with asymptomatic erythematous plaques covering more than 50% of the body surface area and no back pain, what is the recommended treatment for psoriasis?

    <p>Narrowband</p> Signup and view all the answers

    For an adult female with skin-colored papules with induration on the face, trunk, and thighs (scleromyxedema), what would be the treatment option?

    <p>IVIG</p> Signup and view all the answers

    In a patient with eruptive skin papules on the trunk and chest with thread-like border (porokeratosis or seborrheic keratosis), what condition should be considered?

    <p>Precancerous</p> Signup and view all the answers

    What is the characteristic histopathology of porokeratosis of Mabili?

    <p>Parakeratosis and underlying hypergranulosis</p> Signup and view all the answers

    Which type of keratin is associated with PPK (palmoplantar keratoderma)?

    <p>Type 4</p> Signup and view all the answers

    In the picture of nail psoriasis, what type of associated disease is indicated?

    <p>Arthritis</p> Signup and view all the answers

    In the case of a female patient taking biologic treatment for 4 years with improvement, then presenting with scaly erythematous plaque and normal breast cancer investigations, what is the recommended next step?

    <p>Watch</p> Signup and view all the answers

    If a patient taking biologic treatment experiences bloody stool, which type of biologic treatment could be responsible?

    <p>Secukinumab</p> Signup and view all the answers

    In a patient with renal transplantation who develops a maculopapular rash all over the body, which virus is most likely involved?

    <p>Polyoma</p> Signup and view all the answers

    In a patient with lichen planus involving the nails, what is the typical histopathology?

    <p>Hypergranulosis</p> Signup and view all the answers

    In a patient with periumbilical umbilicated papules resembling molluscum and presenting with weight loss and CD4 count less than 200, what investigation is indicated?

    <p>(PET) scan if SMJ nodule to search for primary tumor.</p> Signup and view all the answers

    What is the most effective treatment of plaque psoriasis in a 34-year-old patient?

    <p>(PUVA)</p> Signup and view all the answers

    In a case of localized scales in the scalp beside the ear with no hair loss and erythema, what is the most likely diagnosis?

    <p>(Psoriasis) if pityriasis amentia</p> Signup and view all the answers

    (LP) Lichen planus case histopathology is characterized by:

    <p>(Hypergranulosis)</p> Signup and view all the answers

    For patients with GVHD (chronic type), what biologic treatment is recommended?

    <p>Anti CD20: rituximab</p> Signup and view all the answers

    What epidermal differentiated keratinocytes are typically associated with K1,10?

    <p>K1,10</p> Signup and view all the answers

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