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Questions and Answers
Which histological sign is characteristic of psoriasis?
Which histological sign is characteristic of psoriasis?
- Lymphocytic infiltrate in the subcutaneous tissue
- Accumulation of mast cells in the lower dermis
- Presence of eosinophils in the epidermis
- Capillary dilatation in the upper dermis (Auspitz sign) (correct)
Which variant of psoriasis is characterized by lesions the size of drops of water?
Which variant of psoriasis is characterized by lesions the size of drops of water?
- Nail psoriasis
- Plaque psoriasis
- Scalp psoriasis
- Guttate psoriasis (correct)
Which clinical presentation is often associated with psoriasis?
Which clinical presentation is often associated with psoriasis?
- Blistering and oozing of clear fluid
- Hives-like wheals
- Symmetrical redness and swelling of the joints
- Sharply demarcated, erythematous papules and plaques often covered with silvery-white scales (correct)
What is the most common type of psoriasis affecting around 85% of patients?
What is the most common type of psoriasis affecting around 85% of patients?
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What sign is observed when the covering scale is removed from a psoriatic lesion?
What sign is observed when the covering scale is removed from a psoriatic lesion?
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Study Notes
Papulosquamous Diseases
- Papulosquamous diseases include Psoriasis, Lichen planus, and Pityriasis Rubra pilaris
Psoriasis
- Chronic skin disease with unpredictable remissions and relapses
- Mostly affects adults between 14-40 years old
- Incidence: 1-2% of population
Proactive Factors of Psoriasis
- Genetic: Polygenic inheritance (PSORS1), 30% have positive family history
- Genetic associations: HLA ass B13, BW17, CW6, B27
- Trauma: Koebner phenomenon
- Infection: Streptococcal infection
- Weather: Worse in winter
- Endocrine: Exacerbated by puberty, menopause, and pregnancy
- Drug-induced: Antimalarials, withdrawal of steroids, Lithium, and propranolol
- Emotional stress: 40% of cases
- Lifestyle: Obesity, smoking, and alcoholism
Pathogenesis of Psoriasis
- Stimulation: Trauma, infection, and other factors
- Secretion: IL1, IL8, TNF alpha, interferon gamma, and IL2
- Response: Epidermal hyperproliferation (4-5 days), parakeratosis, and scale formation
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