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Pancreatic Hormones and Antidiabetic Drugs

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Pancreatic Hormones and Antidiabetic Drugs

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Questions and Answers

What is the composition of insulin?

A chain only

B chain only

A&B chains linked by disulfide linkage

Pro-insulin (A chain + Connecting [C] chain + B chain) (correct)

Which cells in the pancreas secrete somatostatin?

PP-cells (F-cells)

Alpha cells (α-cells)

Delta cells (δ-cells) (correct)

Beta cells (β-cells)

What is the mechanism of insulin secretion in beta cells?

Glucose enters by GluT1, decreases ATP, K+ channel blockade, affects Na+ efflux, hyperpolarization of cell membrane, Ca2+ influx, exocytosis of insulin

Glucose enters by GluT1, increases ATP, K+ channel blockade, affects K+ efflux, depolarization of cell membrane, Ca2+ influx, endocytosis of insulin

Glucose enters by GluT2, increases ATP, K+ channel blockade, affects K+ efflux, depolarization of cell membrane, Ca2+ influx, exocytosis of insulin (correct)

Glucose enters by GluT2, increases ATP, K+ channel blockade, affects Na+ efflux, depolarization of cell membrane, Ca2+ influx, exocytosis of insulin