21 Questions
What is the primary function of nociceptors in the pain perception pathway?
To transduce noxious stimuli into electrical signals
What is the term for the heightened response to a stimulus that is normally algesic?
Hyperalgesia
What type of ion channels are involved in the detection of painful stimuli?
Voltage-dependent sodium channels
Which type of pain is characterized by a sustained response to injury, even after the initial stimulus has resolved?
Neuropathic pain
What is the result of the activation of immune cells in inflammatory pain?
Release of inflammatory mediators and chemotactic agents
What is the primary function of the opioid system in the context of pain perception?
To reduce the transmission of noxious stimuli
What is the consequence of nociceptor sensitization in inflammatory pain?
Modulation of peripheral receptor/ion channel properties
What type of agents are involved in the inflammatory cascade?
Inflammatory mediators and chemotactic agents
What is the term for the response to a stimulus that is not normally algesic?
Allodynia
What is the classification of Ab fibers, which are responsible for transmitting information about posture, motion, and position as well as innocuous mechanical and thermal stimuli?
Proprioceptors
What is the effect of NSAIDs on inflammatory pain?
Blocking of inflammatory mediators
Which of the following opioid receptors is primarily responsible for mediating analgesia via spinal mechanisms?
Kappa (KOP) receptor
What is the primary function of the spinoreticular tract in pain perception?
General aspects of pain perception
Which of the following is an endogenous analgesic peptide that is involved in the regulation of pain and mood?
b-Endorphin
What is the mechanism of action of opioids on neurons in the spinal cord?
Opening potassium channels and leading to hyperpolarization of the neuron
Which of the following opioids is known for its high abuse liability and potential for respiratory depression?
Morphine
What is the primary difference between opioid agonists and antagonists?
Agonists activate opioid receptors, while antagonists block them
Which of the following opioid receptors is responsible for mediating the affective and alertive aspects of pain?
Paleospinothalamic tract
What is the primary function of the descending nociceptive pathways in pain perception?
Modulating pain transmission in the spinal cord
Which of the following is a characteristic of opioids that is relevant to their abuse liability?
All of the above
What is the primary mechanism of action of opioid antagonists?
Blocking the action of opioid agonists on opioid receptors
Assess your knowledge of pain pathways and processing, including the spinal organization, signaling, and nociceptors. Learn about the role of opioid receptors and ascending nociceptive pathways.
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