p53 Tumor Suppressor Protein

To control the integrity and correctness of all processes in each individual cell and in the organism as a whole.

It can activate DNA repair proteins when DNA has sustained damage, induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition, or initiate apoptosis if DNA damage proves to be irreparable.

Multiple signaling pathways convey signals modifying activities of p53.

<p>p53, p63, and p73</p> Signup and view all the answers

<p>Up to 50% of human cancers have been found to have p53 mutations.</p> Signup and view all the answers

<p>A binding partner for the SV40 tumor virus oncoprotein large T antigen and an important target for tumor-igenic processes induced by DNA tumor viruses.</p> Signup and view all the answers

<p>the guardian of the genome</p> Signup and view all the answers

<p>p63 and p73</p> Signup and view all the answers

<p>binds to p53 and acts as an E-3 ubiquitin ligase that adds ubiquitin to p53 and results in its degradation</p> Signup and view all the answers

<p>activation of p53</p> Signup and view all the answers

<p>6 to 20 minutes</p> Signup and view all the answers

<p>MDM-X can oligomerize with MDM-2, leading to stabilization of MDM-2 and accelerated degradation</p> Signup and view all the answers

<p>UV, gamma irradiation, genotoxic drugs, nutrition deprivation, heat or cold shock</p> Signup and view all the answers

<p>transactivation domain, DNA binding domain, and oligomerization domain</p> Signup and view all the answers

<p>to one another</p> Signup and view all the answers

<p>MDM-2 acts as an E-3 ubiquitin ligase that adds ubiquitin to p53 and results in its degradation</p> Signup and view all the answers