16 Questions
What is the main function of p53 in the cell?
To control the integrity and correctness of all processes in each individual cell and in the organism as a whole.
How does p53 act as an anti-cancer promotion agent?
It can activate DNA repair proteins when DNA has sustained damage, induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition, or initiate apoptosis if DNA damage proves to be irreparable.
What signaling pathways convey signals modifying activities of p53?
Multiple signaling pathways convey signals modifying activities of p53.
What are the members of the p53 family?
p53, p63, and p73
What percentage of human cancers have been found to have p53 mutations?
Up to 50% of human cancers have been found to have p53 mutations.
What was p53 identified as in the 1970s?
A binding partner for the SV40 tumor virus oncoprotein large T antigen and an important target for tumor-igenic processes induced by DNA tumor viruses.
What is p53 known as because of its ability to protect the cell by inducing cell cycle arrest or apoptosis?
the guardian of the genome
What are the names of the two genes discovered in 1997 that bear significant homology to p53?
p63 and p73
What is the role of MDM-2, the product of a p53-activated gene?
binds to p53 and acts as an E-3 ubiquitin ligase that adds ubiquitin to p53 and results in its degradation
What is the function of ATM protein kinase CHK2 in response to UV, gamma irradiation, and genotoxic drugs?
activation of p53
What is the half-life of the p53 protein when synthesized in cells?
6 to 20 minutes
What is the role of MDM-X in relation to MDM-2?
MDM-X can oligomerize with MDM-2, leading to stabilization of MDM-2 and accelerated degradation
What are some cellular stress signals that appear to activate p53?
UV, gamma irradiation, genotoxic drugs, nutrition deprivation, heat or cold shock
What are the three domains that p63 and p73 share with p53?
transactivation domain, DNA binding domain, and oligomerization domain
What are p63 and p73 more homologous to, compared to p53?
to one another
What is the role of MDM-2 in the autoregulatory loop involving p53?
MDM-2 acts as an E-3 ubiquitin ligase that adds ubiquitin to p53 and results in its degradation
Test your knowledge about the tumor suppressor protein p53 and its role in cancer. Learn about its discovery, functions as a transcription factor, and its significance in tumor-igenic processes.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
