p53 Tumor Suppressor Protein

To control the integrity and correctness of all processes in each individual cell and in the organism as a whole.

p53, p63, and p73.

It can activate DNA repair proteins, induce growth arrest, or initiate apoptosis if DNA damage proves to be irreparable.

<p>Up to 50%.</p> Signup and view all the answers

<p>Tumor suppressor protein.</p> Signup and view all the answers

<p>As a transcription factor that activates and represses a growing number of target genes implicated in cell cycle control.</p> Signup and view all the answers

<p>Guardian of the genome</p> Signup and view all the answers

<p>Transactivation domain, DNA binding domain, and oligomerization domain</p> Signup and view all the answers

<p>Play different roles</p> Signup and view all the answers

<p>UV, Ƴ-irradiation, genotoxic drugs, nutrition deprivation, heat or cold shock</p> Signup and view all the answers

<p>MDM-2</p> Signup and view all the answers

<p>Binds to p53 and acts as an E-3 ubiquitin ligase that adds ubiquitin to p53 and results in its degradation</p> Signup and view all the answers

<p>Can oligomerize with MDM-2, which leads to stabilization of MDM-2 and accelerated degradation</p> Signup and view all the answers

<p>UV, gamma irradiation, genotoxic drugs</p> Signup and view all the answers

<p>ATR kinase CHK1</p> Signup and view all the answers

<p>Activated in response to DNA damage</p> Signup and view all the answers