12 Questions
What is the terminal half-life of the medication described in the text?
4 hours
Which enzymes are involved in the metabolism of the described medication?
P450-3A4
What drug interaction can decrease the metabolism of the described medication?
Cimetidine
In which condition should the described medication not be co-administered with nitrates?
Retinitis pigmentosa
Which adverse effect can result from overdosage of oxytocin?
Fetal hypoxia
What is a potential consequence of high doses of oxytocin besides water intoxication?
Uterine rupture
How do ergometrine and methylergometrine differ in pharmacological potency?
Ergometrine causes stronger uterine contractions
What is the main pharmacological effect of ergometrine and methylergometrine on the uterus?
Promotes uterine tetany
What is the effect of oxytocin on uterine muscle compared to intestinal muscle and coronary arteries?
Stimulates contraction in uterine muscle but has little to no effect on intestinal muscle or coronary arteries
Which type of adrenergic receptors are found in uterine receptor sites?
α and β2
Which hormone is required for the promotion of mammary development, lactation, and galactopoiesis?
Growth hormone
What is the mechanism of action of oxytocin on the myometrium?
Leads to generation of inositol triphosphate (IP3) and release of Ca2+ from intracellular stores
Learn about the medical uses of oxytocin such as preventing postpartum uterine atony, expelling the placenta, and stimulating milk let-down while understanding its adverse effects like uterine hyperstimulation and potential fetal hypoxia. Be cautious of the dosage and side effects associated with oxytocin administration.
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