Oxytocin and Uterine Contractions
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Questions and Answers

Which molecule is released into the cytoplasm when phospholipase C cleaves phosphatidylinositol 4,5-bisphosphate (PIP2)?

  • Inositol 1,4,5-trisphosphate (IP3) (correct)
  • Diacylglycerol (DAG)
  • Calmodulin
  • Calcium

    • What is the role of IP3 receptors in the contraction of uterine smooth muscle?

  • They permit the passage of calcium from the sarcoplasmic reticulum (SR) to the cytoplasm (correct)
  • They bind to calmodulin
  • They phosphorylate myosin light chains
  • They activate phospholipase C

    • What is the role of MLCK in the contraction of uterine smooth muscle?

  • It phosphorylates myosin light chains (correct)
  • It binds to calmodulin
  • It permits the passage of calcium from the sarcoplasmic reticulum (SR) to the cytoplasm
  • It activates phospholipase C

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