Oxygen Binding to Myoglobin and Hemoglobin

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Which amino acid residue in myoglobin binds to Fe2+?

Proline

Leucine

Glycine

Histidine (correct)

What type of interactions hold the two 𝛼β dimers together in the T form of hemoglobin?

Disulfide bonds

Ionic and H-bonds (correct)

Hydrophobic interactions

Van der Waals forces

How are 𝛼-helical regions typically terminated in proteins?

By the presence of Tryptophan

By the presence of Proline (correct)

By the presence of Histidine

By the presence of Lysine

What is the function of Distal Histidine (E7) in myoglobin?

Stabilizes binding of O2 to Fe2+ Signup and view all the answers

In the T form of hemoglobin, how would you describe its affinity for O2?

Low Signup and view all the answers

Which of the following molecules can hemoglobin bind to, besides O2?

$CO_2$ Signup and view all the answers

What is the main function of hemoglobin in the body?

Transporting O2 from lungs to tissues Signup and view all the answers

Which metal ion is complexed with protoporphyrin IX in heme?

Iron (Fe) Signup and view all the answers

What is the main structural difference between myoglobin and hemoglobin?

Hemoglobin is made up of 4 polypeptide chains, while myoglobin is made up of a single polypeptide chain Signup and view all the answers

Which of the following is true about the structure of heme?

The nitrogen atoms of porphyrin rings bind to metal ions Signup and view all the answers

Which part of the body does myoglobin primarily function in?

Muscle cells Signup and view all the answers

What is the significance of myoglobin and hemoglobin in relation to oxygen binding?

Myoglobin has a higher affinity for oxygen than hemoglobin Signup and view all the answers

What type of bonds are ruptured upon O2 binding to the R form of hemoglobin?

Ionic bonds Signup and view all the answers

How many molecules of O2 can myoglobin bind, and what is the shape of its binding curve?

1 molecule, hyperbolic Signup and view all the answers

Which protein, myoglobin or hemoglobin, has a higher affinity for O2?

Myoglobin Signup and view all the answers

What is the effect of carbon monoxide on the oxygen affinity of hemoglobin?

Decreases oxygen affinity Signup and view all the answers

How does the binding of an oxygen molecule at one heme group affect the oxygen affinity of the remaining heme groups in the same hemoglobin molecule?

Increases their affinity Signup and view all the answers

Which of the following effector molecules influences the reversible binding of O2 by hemoglobin?

$CO_2$ levels Signup and view all the answers