Oxygen Binding to Myoglobin and Hemoglobin
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which amino acid residue in myoglobin binds to Fe2+?

  • Proline
  • Leucine
  • Glycine
  • Histidine (correct)

    • What type of interactions hold the two 𝛼β dimers together in the T form of hemoglobin?

  • Disulfide bonds
  • Ionic and H-bonds (correct)
  • Hydrophobic interactions
  • Van der Waals forces

    • How are 𝛼-helical regions typically terminated in proteins?

  • By the presence of Tryptophan
  • By the presence of Proline (correct)
  • By the presence of Histidine
  • By the presence of Lysine

    • What is the function of Distal Histidine (E7) in myoglobin?

    <p>Stabilizes binding of O2 to Fe2+</p> Signup and view all the answers

    In the T form of hemoglobin, how would you describe its affinity for O2?

    <p>Low</p> Signup and view all the answers

    Which of the following molecules can hemoglobin bind to, besides O2?

    <p>$CO_2$</p> Signup and view all the answers

    What is the main function of hemoglobin in the body?

    <p>Transporting O2 from lungs to tissues</p> Signup and view all the answers

    Which metal ion is complexed with protoporphyrin IX in heme?

    <p>Iron (Fe)</p> Signup and view all the answers

    What is the main structural difference between myoglobin and hemoglobin?

    <p>Hemoglobin is made up of 4 polypeptide chains, while myoglobin is made up of a single polypeptide chain</p> Signup and view all the answers

    Which of the following is true about the structure of heme?

    <p>The nitrogen atoms of porphyrin rings bind to metal ions</p> Signup and view all the answers

    Which part of the body does myoglobin primarily function in?

    <p>Muscle cells</p> Signup and view all the answers

    What is the significance of myoglobin and hemoglobin in relation to oxygen binding?

    <p>Myoglobin has a higher affinity for oxygen than hemoglobin</p> Signup and view all the answers

    What type of bonds are ruptured upon O2 binding to the R form of hemoglobin?

    <p>Ionic bonds</p> Signup and view all the answers

    How many molecules of O2 can myoglobin bind, and what is the shape of its binding curve?

    <p>1 molecule, hyperbolic</p> Signup and view all the answers

    Which protein, myoglobin or hemoglobin, has a higher affinity for O2?

    <p>Myoglobin</p> Signup and view all the answers

    What is the effect of carbon monoxide on the oxygen affinity of hemoglobin?

    <p>Decreases oxygen affinity</p> Signup and view all the answers

    How does the binding of an oxygen molecule at one heme group affect the oxygen affinity of the remaining heme groups in the same hemoglobin molecule?

    <p>Increases their affinity</p> Signup and view all the answers

    Which of the following effector molecules influences the reversible binding of O2 by hemoglobin?

    <p>$CO_2$ levels</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser