15 Questions
What is the primary mechanism of action of lamotrigine?
Blocking voltage-gated sodium channels
Which of the following statements about lamotrigine's pharmacokinetics is correct?
It has a high protein binding of around 55%
Which of the following is a common adverse effect associated with oxcarbazepine?
Diplopia
What is the primary role of the UGT enzyme system in the context of antiepileptic drugs?
Metabolizing and eliminating drugs
Which of the following statements about the excretion of oxcarbazepine is true?
It is primarily excreted as an inactive glucuronide conjugate
What is the maximum recommended IV infusion rate for phenytoin?
50 mg/min
What is the primary reason for the recommended limit on the IV infusion rate of phenytoin?
The propylene glycol diluent can cause severe cardiac effects if infused too quickly
How does the co-administration of CYP 450 inducers affect phenytoin plasma concentrations?
CYP 450 inducers decrease phenytoin plasma concentrations
How does the co-administration of CYP 450 inhibitors affect phenytoin plasma concentrations?
CYP 450 inhibitors increase phenytoin plasma concentrations
What is the primary reason phenytoin has a high risk of toxicity when co-administered with other highly protein-bound drugs?
Phenytoin is highly protein bound, so other protein-bound drugs can displace it from albumin, increasing the free, unbound concentration
What is a key advantage of fosphenytoin compared to phenytoin?
Fosphenytoin can be administered IM without risk of precipitation or erratic absorption
Which of the following is a common adverse effect associated with phenytoin therapy?
Gingival hyperplasia
Which of the following statements about the pharmacokinetics of phenytoin is correct?
Phenytoin has linear pharmacokinetics at all doses
What is the recommended loading dose of phenytoin for status epilepticus?
16-20 mg/kg IV
Which of the following is a key difference between phenytoin and fosphenytoin?
Fosphenytoin can be administered IM without risk of precipitation or erratic absorption
Test your knowledge on the pharmacokinetics and mechanism of action of Oxcarbazepine (Trileptal®), including its metabolism, protein binding, and anti-seizure activity. Learn about its fast Na+ channel blocking properties and its use in managing partial and generalized tonic-clonic seizures.
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