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Questions and Answers
What is the primary mechanism of action of lamotrigine?
What is the primary mechanism of action of lamotrigine?
- Blocking voltage-gated sodium channels (correct)
- Inhibiting GABA transaminase
- Blocking T-type calcium channels
- Inhibiting glutamate release
Which of the following statements about lamotrigine's pharmacokinetics is correct?
Which of the following statements about lamotrigine's pharmacokinetics is correct?
- It has a high protein binding of around 55% (correct)
- It has a half-life of approximately 24 hours
- It undergoes extensive hepatic metabolism by CYP3A4
- It has a bioavailability of 100%
Which of the following is a common adverse effect associated with oxcarbazepine?
Which of the following is a common adverse effect associated with oxcarbazepine?
- Hyponatremia
- Hiccups
- Bone marrow suppression
- Diplopia (correct)
What is the primary role of the UGT enzyme system in the context of antiepileptic drugs?
What is the primary role of the UGT enzyme system in the context of antiepileptic drugs?
Which of the following statements about the excretion of oxcarbazepine is true?
Which of the following statements about the excretion of oxcarbazepine is true?
What is the maximum recommended IV infusion rate for phenytoin?
What is the maximum recommended IV infusion rate for phenytoin?
What is the primary reason for the recommended limit on the IV infusion rate of phenytoin?
What is the primary reason for the recommended limit on the IV infusion rate of phenytoin?
How does the co-administration of CYP 450 inducers affect phenytoin plasma concentrations?
How does the co-administration of CYP 450 inducers affect phenytoin plasma concentrations?
How does the co-administration of CYP 450 inhibitors affect phenytoin plasma concentrations?
How does the co-administration of CYP 450 inhibitors affect phenytoin plasma concentrations?
What is the primary reason phenytoin has a high risk of toxicity when co-administered with other highly protein-bound drugs?
What is the primary reason phenytoin has a high risk of toxicity when co-administered with other highly protein-bound drugs?
What is a key advantage of fosphenytoin compared to phenytoin?
What is a key advantage of fosphenytoin compared to phenytoin?
Which of the following is a common adverse effect associated with phenytoin therapy?
Which of the following is a common adverse effect associated with phenytoin therapy?
Which of the following statements about the pharmacokinetics of phenytoin is correct?
Which of the following statements about the pharmacokinetics of phenytoin is correct?
What is the recommended loading dose of phenytoin for status epilepticus?
What is the recommended loading dose of phenytoin for status epilepticus?
Which of the following is a key difference between phenytoin and fosphenytoin?
Which of the following is a key difference between phenytoin and fosphenytoin?
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