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Oxcarbazepine Pharmacokinetics and Mechanism of Action Quiz

15 Questions

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Oxcarbazepine Pharmacokinetics and Mechanism of Action Quiz

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Questions and Answers

What is the primary mechanism of action of lamotrigine?

Blocking voltage-gated sodium channels (correct)

Inhibiting GABA transaminase

Blocking T-type calcium channels

Inhibiting glutamate release

Which of the following statements about lamotrigine's pharmacokinetics is correct?

It has a high protein binding of around 55% (correct)

It has a half-life of approximately 24 hours

It undergoes extensive hepatic metabolism by CYP3A4

It has a bioavailability of 100%

Which of the following is a common adverse effect associated with oxcarbazepine?

Hyponatremia

Hiccups

Bone marrow suppression

Diplopia (correct)

What is the primary role of the UGT enzyme system in the context of antiepileptic drugs?

Metabolizing and eliminating drugs Signup and view all the answers

Which of the following statements about the excretion of oxcarbazepine is true?

It is primarily excreted as an inactive glucuronide conjugate Signup and view all the answers

What is the maximum recommended IV infusion rate for phenytoin?

50 mg/min Signup and view all the answers

What is the primary reason for the recommended limit on the IV infusion rate of phenytoin?

The propylene glycol diluent can cause severe cardiac effects if infused too quickly Signup and view all the answers

How does the co-administration of CYP 450 inducers affect phenytoin plasma concentrations?

CYP 450 inducers decrease phenytoin plasma concentrations Signup and view all the answers

How does the co-administration of CYP 450 inhibitors affect phenytoin plasma concentrations?

CYP 450 inhibitors increase phenytoin plasma concentrations Signup and view all the answers

What is the primary reason phenytoin has a high risk of toxicity when co-administered with other highly protein-bound drugs?

Phenytoin is highly protein bound, so other protein-bound drugs can displace it from albumin, increasing the free, unbound concentration Signup and view all the answers

What is a key advantage of fosphenytoin compared to phenytoin?

Fosphenytoin can be administered IM without risk of precipitation or erratic absorption Signup and view all the answers

Which of the following is a common adverse effect associated with phenytoin therapy?

Gingival hyperplasia Signup and view all the answers

Which of the following statements about the pharmacokinetics of phenytoin is correct?

Phenytoin has linear pharmacokinetics at all doses Signup and view all the answers

What is the recommended loading dose of phenytoin for status epilepticus?

16-20 mg/kg IV Signup and view all the answers

Which of the following is a key difference between phenytoin and fosphenytoin?