Podcast
Questions and Answers
What is a common leading cause of death in patients with SLE?
What is a common leading cause of death in patients with SLE?
- Septicemia (correct)
- Myocardial infarction
- Acute renal failure
- Stroke
Which of the following is least likely to be a joint manifestation in patients with SLE?
Which of the following is least likely to be a joint manifestation in patients with SLE?
- Multiple arthralgias
- Synovitis
- Deformities in joint structure (correct)
- Symmetric polyarthritis
Which skin manifestation is characteristic of SLE?
Which skin manifestation is characteristic of SLE?
- Psoriasis
- Eczema
- Butterfly rash (correct)
- Fungal infection
What percentage of individuals with SLE experience renal manifestations?
What percentage of individuals with SLE experience renal manifestations?
Which of the following is NOT a typical early manifestation of SLE?
Which of the following is NOT a typical early manifestation of SLE?
Which type of lesions can be commonly found in patients with SLE?
Which type of lesions can be commonly found in patients with SLE?
Which hematologic abnormality is commonly associated with SLE?
Which hematologic abnormality is commonly associated with SLE?
What is a typical skin reaction for patients with SLE when exposed to sunlight?
What is a typical skin reaction for patients with SLE when exposed to sunlight?
Which of the following symptoms is most often reported as extreme in patients with SLE?
Which of the following symptoms is most often reported as extreme in patients with SLE?
What percentage of patients with SLE experience renal failure as a result of the disease?
What percentage of patients with SLE experience renal failure as a result of the disease?
Which treatment option is primarily indicated for managing inflammation in pericarditis?
Which treatment option is primarily indicated for managing inflammation in pericarditis?
What is a key symptom of pericarditis that differentiates it from other causes of chest pain?
What is a key symptom of pericarditis that differentiates it from other causes of chest pain?
In which condition is pericardiocentesis indicated?
In which condition is pericardiocentesis indicated?
Which manifestation is NOT commonly associated with renal involvement in systemic lupus erythematosus?
Which manifestation is NOT commonly associated with renal involvement in systemic lupus erythematosus?
What is the primary goal of treatment for renal involvement in systemic lupus erythematosus?
What is the primary goal of treatment for renal involvement in systemic lupus erythematosus?
Which of the following is a common ECG finding in pericarditis?
Which of the following is a common ECG finding in pericarditis?
Which treatment option is least likely to be used for infectious pericarditis?
Which treatment option is least likely to be used for infectious pericarditis?
Which of these findings is indicative of nephrotic syndrome?
Which of these findings is indicative of nephrotic syndrome?
What is the potential complication of renal failure in systemic lupus erythematosus?
What is the potential complication of renal failure in systemic lupus erythematosus?
Which treatment is not typically used for treating pericarditis?
Which treatment is not typically used for treating pericarditis?
Which of the following symptoms is least likely to be an early sign of systemic lupus erythematosus (SLE)?
Which of the following symptoms is least likely to be an early sign of systemic lupus erythematosus (SLE)?
What is the most common neurological manifestation associated with systemic lupus erythematosus?
What is the most common neurological manifestation associated with systemic lupus erythematosus?
In treating anemia related to SLE, which of the following methods is least likely to be used initially?
In treating anemia related to SLE, which of the following methods is least likely to be used initially?
Which treatment option is specifically aimed at managing arthralgias and arthritis in SLE patients?
Which treatment option is specifically aimed at managing arthralgias and arthritis in SLE patients?
Which of the following is NOT a common pulmonary manifestation of systemic lupus erythematosus?
Which of the following is NOT a common pulmonary manifestation of systemic lupus erythematosus?
Which statement about the survival rates of systemic lupus erythematosus is TRUE?
Which statement about the survival rates of systemic lupus erythematosus is TRUE?
What is the primary cause of leukopenia in patients with SLE?
What is the primary cause of leukopenia in patients with SLE?
Which of the following GI manifestations can occur in up to 45% of patients with systemic lupus erythematosus?
Which of the following GI manifestations can occur in up to 45% of patients with systemic lupus erythematosus?
Which of the following options accurately describes a common skin manifestation of SLE?
Which of the following options accurately describes a common skin manifestation of SLE?
What is a common treatment for transient CNS involvement in SLE?
What is a common treatment for transient CNS involvement in SLE?
Flashcards
SLE Exacerbation
SLE Exacerbation
Periods of worsening SLE symptoms.
SLE remission
SLE remission
Periods of reduced SLE symptoms.
Butterfly rash
Butterfly rash
Red rash on the cheeks and nose, characteristic of SLE.
Photosensitivity
Photosensitivity
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SLE kidney involvement
SLE kidney involvement
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SLE joint symptoms
SLE joint symptoms
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SLE infections
SLE infections
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SLE common manifestations
SLE common manifestations
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SLE Renal Failure
SLE Renal Failure
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SLE Hematologic issues
SLE Hematologic issues
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SLE Fever
SLE Fever
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SLE Malaise
SLE Malaise
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SLE Loss of Appetite
SLE Loss of Appetite
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SLE Arthritis
SLE Arthritis
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SLE Skin Involvement
SLE Skin Involvement
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SLE Organic Brain Syndrome
SLE Organic Brain Syndrome
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SLE Anemia
SLE Anemia
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SLE Leukopenia
SLE Leukopenia
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SLE Thrombocytopenia
SLE Thrombocytopenia
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SLE Treatment Goals
SLE Treatment Goals
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SLE Treatment
SLE Treatment
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Pericarditis in SLE
Pericarditis in SLE
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Pericarditis Treatment
Pericarditis Treatment
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Kidney Involvement Treatment
Kidney Involvement Treatment
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What is IV IgG?
What is IV IgG?
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What is Splenectomy?
What is Splenectomy?
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What is Colchicine?
What is Colchicine?
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What is Pericardiocentesis?
What is Pericardiocentesis?
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What are Cellular Casts?
What are Cellular Casts?
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Study Notes
Systemic Lupus Erythematosus (SLE) Overview
- SLE course is typically mild with remission and exacerbation, often decreasing in severity over time.
- Some cases are severe with significant organ involvement.
- Infections (pneumonia, septicemia) are leading causes of death in SLE patients, followed by kidney or CNS issues.
- Early SLE mimics Rheumatoid Arthritis (RA) with fever, loss of appetite, malaise, weight loss, and multiple arthralgias/symmetric polyarthritis.
- Joint symptoms affect over 90% of SLE patients, but arthritis is rarely deforming.
- Skin manifestations are common, including butterfly rash (across cheeks and nose), photosensitivity, and various rashes (discoid, hives).
- Alopecia (hair loss) is also common but often reversible.
- Common manifestations include joint pain/swelling, muscle pain, unexplained fever, red rash, hair loss, pale/cyanotic extremities, sun sensitivity, edema, mouth ulcers, and fatigue.
SLE Renal Involvement
- Approximately 50% of SLE patients have kidney problems (proteinuria, cellular casts, nephrotic syndrome).
- Up to 10% develop renal failure.
- Kidney failure is treated with dialysis or transplant.
SLE Hematologic and Cardiovascular Involvement
- Common hematologic issues include anemia, leukopenia, and thrombocytopenia.
- Cardiovascular complications include pericarditis, vasculitis, and Raynaud's phenomenon.
- Less common are myocarditis, endocarditis, and vascular thrombosis.
SLE Pulmonary, Neurological, and Gastrointestinal Involvement
- Pulmonary involvement includes pleurisy, pleural effusions, and lupus pneumonitis.
- Neurological involvement, often appearing within the first year, includes organic brain syndrome (cognitive decline), psychosis, seizures, depression, stroke, conjunctivitis, photophobia, and transient blindness.
- Gastrointestinal manifestations (anorexia, nausea, abdominal pain, diarrhea) may affect up to 45% of patients, potentially with liver enlargement and function abnormalities.
SLE Prognosis and Treatment
- SLE survival rate has improved significantly since the 1950s, with 10-year survival exceeding 90%.
- Prognosis depends on organ involvement severity.
- Treatment focuses on managing specific symptoms and underlying organ issues.
SLE Early Manifestations and Management
- Unexplained fever, malaise, loss of appetite, weight loss, and joint symptoms (arthralgias/arthritis) are early signs.
- Fever management: NSAIDs or acetaminophen.
- Malaise management: adequate rest, sleep.
- Appetite loss: identifying underlying causes (dysphagia, esophagitis).
- Weight loss: treating underlying causes, high-calorie meals.
- Arthritis: antimalarials, analgesics, short-term glucocorticoids.
SLE Skin Involvement and Management
- Photosensitivity, widespread rashes, alopecia, and other skin manifestations are common.
- Treatment options: corticosteroids, immunosuppressants, disease-modifying antirheumatic drugs, a suitable diet.
SLE Neurological Involvement and Management
- Neurologic involvement includes organic brain syndrome, a general term for impaired mental function related to SLE.
- Management focuses on treating the underlying condition (SLE).
SLE Anemia, Leukopenia, and Thrombocytopenia Management
- Anemia: increased iron intake, iron supplements, medications to stimulate red blood cell production (erythropoietin), and blood transfusions (severe cases).
- Leukopenia: managing the underlying cause predominantly. Supportive care includes antibiotics, protective isolation, and aseptic techniques to prevent infections.
- Thrombocytopenia: treatment guided by underlying cause and severity; corticosteroids, IV IgG, splenectomy, platelet transfusions may be necessary.
SLE Pericarditis Management
- Chest pain, dry cough, fever, fatigue, anxiety, friction rub, ECG abnormalities are common symptoms.
- Treatment options include pericardiocentesis, antibiotics (if infectious), corticosteroids, and colchicine.
SLE Renal Involvement and Management
- Proteinuria, cellular casts, nephrotic syndrome, and renal failure are renal involvement symptoms.
- Management focuses on correcting underlying issues and relieving stress on the kidney; dialysis may be needed in cases of renal failure.
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Description
This quiz provides an overview of Systemic Lupus Erythematosus (SLE), focusing on its symptoms, severity, and renal involvement. Understand the connections between SLE, arthralgia, skin symptoms, and the typical course of the disease. Test your knowledge about the manifestations and complications associated with this autoimmune disorder.