Questions and Answers
What is the generic name of ranitidine?
ranitidine
Which of the following are trade names for ranitidine? (Select all that apply)
What is the therapeutic classification of ranitidine?
antiulcer agent
What is the pharmacologic classification of ranitidine?
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The primary indication for the use of ranitidine is __________.
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What is one of the actions of ranitidine?
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What are the therapeutic effects of ranitidine?
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Which lab tests might be affected by ranitidine? (Select all that apply)
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What are the common adverse reactions associated with ranitidine?
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What is a contraindication for using ranitidine?
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What should be assessed in patients taking ranitidine?
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Patients should not take the maximum dose of ranitidine for more than __________ weeks.
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What dietary advice should be given to patients taking ranitidine?
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Study Notes
Ranitidine Overview
- Generic Name: Ranitidine
- Trade Names: Acid Reducer, Zantac, Zantac EFFERdose, Zantac 75, Zantac 150
Classification
- Therapeutic Classification: Antiulcer agent
- Pharmacologic Classification: Histamine H2 antagonists
Indications
- Maintenance therapy for healing duodenal and gastric ulcers
- Management of gastroesophageal reflux disease (GERD)
- Treatment of heartburn, acid indigestion, and sour stomach
- Management of gastric hypersecretory states
- Erosive esophagitis treatment and maintenance therapy
- Management of NSAID-associated gastrointestinal symptoms
- Prevention of acid inactivation of pancreatic enzymes in insufficiency
- Management of urticaria
Mechanism of Action
- Inhibits histamine H2 receptors in gastric parietal cells
- Reduces gastric acid secretion
Therapeutic Effects
- Promotes healing and prevention of ulcers
- Decreases gastroesophageal reflux
- Lowers gastric acid secretion
Laboratory Tests
- Complete Blood Count (CBC) monitoring
- May interfere with pentagastrin and histamine during gastric acid tests
- Possible false negatives in skin testing using allergenic extracts
- Watch for increased serum transaminases and creatinine
- Potential false positives in urine protein tests
Adverse Reactions/Side Effects
- CNS: Confusion (most common side effect)
- Cardiovascular: Life-threatening arrhythmias
- Hematologic: Life-threatening agranulocytosis and aplastic anemia
Contraindications and Cautions
- Hypersensitivity reactions
- Products containing alcohol are contraindicated for those with alcohol intolerance
- Products with aspartame should be avoided in patients with phenylketonuria
- Caution in patients with renal impairment and acute porphyria
- Increased risk of CNS reactions in elderly patients
- OB and lactation should involve lower dosages
Nursing Implications
- Assess for abdominal pain and blood in stools or gastric aspirates
- Regularly screen elderly or debilitated patients for confusion
Family Teaching
- Do not exceed the maximum dose for over 2 weeks; report persistent symptoms
- Smoking can reduce the effectiveness of histamine antagonists
- May cause drowsiness; caution advised
- Avoid alcohol, aspirin, NSAIDs, and GI-upsetting foods
- Emphasize the importance of increased fiber, fluids, and exercise
- Report severe symptoms such as black tarry stools, fever, or confusion to healthcare provider
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Description
This quiz provides an in-depth overview of Ranitidine, including its classification, indications, mechanism of action, and therapeutic effects. Test your knowledge on how this antiulcer agent functions and its application in various gastrointestinal conditions.
