16 Questions
Which of the following diseases is NOT treated with antiprotozoal drugs?
Tuberculosis
What is the characteristic feature of Amebiasis (amebic dysentery)?
It is an infection of the intestinal tract
How is diagnosis of Amebiasis established?
By isolating E. histolytica from feces
Which type of amebicides are effective against amebas in the lumen of the bowel?
Luminal amebicides
What is the main challenge with antiprotozoal drugs for treating protozoal diseases?
They have serious toxic effects on the host
What is the potential risk associated with asymptomatic carriers of E. histolytica?
They may be a potential source of infection for others
What is the drug of choice for treating amebic infections?
Metronidazole
Which drug is a second-generation nitroimidazole with a spectrum of activity similar to metronidazole?
Tinidazole
What adverse effect is common with metronidazole usage?
Unpleasant metallic taste
Which drug should be avoided during therapy due to its interaction with alcohol?
Tinidazole
Which drug is effective against luminal trophozoite and cyst forms of Entamoeba histolytica?
Iodoquinol
Which drug is as effective as metronidazole but more expensive?
Tinidazole
What is the resistance status of metronidazole in the treatment of amebiasis?
No therapeutic problem
Where can therapeutic levels of metronidazole be found after oral administration?
Vaginal and seminal fluids, saliva, breast milk, and cerebrospinal fluid (CSF)
What is a rare adverse effect of metronidazole that may necessitate drug discontinuation?
Peripheral neuropathy
Which drug is a luminal agent used for treatment of asymptomatic colonization state after complete treatment of invasive intestinal or extra-intestinal amebic disease?
Paromomycin
This quiz provides an overview of antiprotozoal drugs, including their use in treating diseases such as amebiasis, malaria, trypanosomiasis, leishmaniasis, toxoplasmosis, and giardiasis. It covers the challenges in treating protozoal diseases and the potential toxic effects of antiprotozoal drugs on the host.
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