Overview of Antiprotozoal Drugs
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Questions and Answers

Which of the following diseases is NOT treated with antiprotozoal drugs?

  • Tuberculosis (correct)
  • Amebiasis
  • Malaria
  • Trypanosomiasis

What is the characteristic feature of Amebiasis (amebic dysentery)?

  • It primarily affects the respiratory system
  • It is an infection of the intestinal tract (correct)
  • It only affects young children
  • It causes severe skin rashes

How is diagnosis of Amebiasis established?

  • Through urine analysis
  • Through blood culture
  • Through skin biopsy
  • By isolating E. histolytica from feces (correct)

Which type of amebicides are effective against amebas in the lumen of the bowel?

<p>Luminal amebicides (B)</p> Signup and view all the answers

What is the main challenge with antiprotozoal drugs for treating protozoal diseases?

<p>They have serious toxic effects on the host (B)</p> Signup and view all the answers

What is the potential risk associated with asymptomatic carriers of E. histolytica?

<p>They may be a potential source of infection for others (D)</p> Signup and view all the answers

What is the drug of choice for treating amebic infections?

<p>Metronidazole (A)</p> Signup and view all the answers

Which drug is a second-generation nitroimidazole with a spectrum of activity similar to metronidazole?

<p>Tinidazole (C)</p> Signup and view all the answers

What adverse effect is common with metronidazole usage?

<p>Unpleasant metallic taste (C)</p> Signup and view all the answers

Which drug should be avoided during therapy due to its interaction with alcohol?

<p>Tinidazole (B)</p> Signup and view all the answers

Which drug is effective against luminal trophozoite and cyst forms of Entamoeba histolytica?

<p>Iodoquinol (A)</p> Signup and view all the answers

Which drug is as effective as metronidazole but more expensive?

<p>Tinidazole (B)</p> Signup and view all the answers

What is the resistance status of metronidazole in the treatment of amebiasis?

<p>No therapeutic problem (C)</p> Signup and view all the answers

Where can therapeutic levels of metronidazole be found after oral administration?

<p>Vaginal and seminal fluids, saliva, breast milk, and cerebrospinal fluid (CSF) (D)</p> Signup and view all the answers

What is a rare adverse effect of metronidazole that may necessitate drug discontinuation?

<p>Peripheral neuropathy (C)</p> Signup and view all the answers

Which drug is a luminal agent used for treatment of asymptomatic colonization state after complete treatment of invasive intestinal or extra-intestinal amebic disease?

<p>Paromomycin (D)</p> Signup and view all the answers

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