Overview of Antiprotozoal Drugs

Which type of drugs cause serious toxic effects in the host, particularly on cells showing high metabolic activity?

What infection is caused by Entamoeba histolytica?

Which disease can be acute or chronic, with varying degrees of illness, from no symptoms to mild diarrhea to fulminating dysentery?

What is the main diagnostic method for establishing Amebiasis?

What is the classification of therapeutic agents for amebiasis based on?

Which type of amebicides are effective against both the luminal and systemic forms of amebiasis?

What is the drug of choice for treating amebic infections?

Which drug is a prodrug that is reduced intracellularly by anaerobic bacteria to its active form?

Which drug is effective against E. histolytica trophozoites and cyst forms?

Which drug accumulates in patients with severe hepatic disease?

Which drug should be avoided during alcohol consumption?

Which drug is used for treatment of giardiasis and trichomoniasis?

Which drug is used for treatment of asymptomatic colonization state after completion of invasive intestinal or extra-intestinal amebic disease treatment?

Which drug has adverse effects including rash, diarrhea, and dose-related peripheral neuropathy, including a rare optic neuritis?

Amebiasis is an infection of the intestinal tract caused by Entamoeba ______.

Anti-protozoal drugs are used for the treatment of Amebiasis, Malaria, Trypanosomiasis, Leishmaniasis, Toxoplasmosis, and ______.

Therapeutic agents for amebiasis are classified according to the site of action as: Luminal amebicides act on the parasite in the lumen of the bowel, Systemic amebicides are effective against amebas in the intestinal wall and ______.

Amebiasis can be acute or chronic, with varying degrees of illness, from no symptoms to mild diarrhea to fulminating ______.

Diagnosis of Amebiasis is established by isolating E. ______ from feces.

Therapy for Amebiasis is indicated for acutely ill patients and asymptomatic carriers, since dormant E. histolytica may cause future infections in the carrier and be a potential source of infection for ______.

Metronidazole, a nitroimidazole, is the __________ amebicide of choice for treating amebic infections.

Metronidazole is the drug of choice for the treatment of pseudomembranous colitis caused by the anaerobic Clostridium __________.

Metronidazole is a prodrug that is reduced intracellularly by the anaerobic bacteria to its active ________.

Metronidazole is completely and rapidly absorbed after oral administration and therapeutic levels can be found in vaginal and seminal fluids, saliva, breast milk, and cerebrospinal fluid (CSF). The drug accumulates in patients with severe ________ disease.

The parent drug and its metabolites are excreted in the ________.

Tinidazole is a second-generation nitroimidazole that is similar to metronidazole in spectrum of activity, absorption, adverse effects, and drug ________.

Tinidazole is as effective as metronidazole, with a shorter course of treatment, but it is more ________.

A luminal agent, such as: iodoquinol, diloxanide furoate, paromomycin, should be administered for treatment of the asymptomatic colonization ________.

Iodoquinol, a halogenated 8- hydroxyquinolone, is amebicidal against E. histolytica and is effective against the luminal trophozoite and cyst ________.

Adverse effects of iodoquinol include rash, diarrhea, and dose-related peripheral neuropathy, including a rare optic ________.