Podcast
Questions and Answers
What is the primary function of 1, 25 (OH)2 D in bone mineral homeostasis?
What is the primary function of 1, 25 (OH)2 D in bone mineral homeostasis?
- Stimulates intestinal uptake of calcium and phosphate and promotes bone formation (correct)
- Inhibits PTH production
- Inhibits bone formation
- Regulates osteoclast activity
Which of the following hormones inhibits bone resorption?
Which of the following hormones inhibits bone resorption?
- Vitamin D
- Calcitonin (correct)
- Parathyroid hormone
- Estrogen
What is the effect of vitamin D deficiency on bone formation?
What is the effect of vitamin D deficiency on bone formation?
- Bone formation is stimulated
- Bone resorption is inhibited
- Bone formation is impaired (correct)
- Bone density is unaffected
Which cell type produces RANKL, stimulating preosteoclast differentiation?
Which cell type produces RANKL, stimulating preosteoclast differentiation?
What is the outcome of increased osteoclast activity due to high PTH levels?
What is the outcome of increased osteoclast activity due to high PTH levels?
Which of the following is a secondary regulator of bone mineral homeostasis?
Which of the following is a secondary regulator of bone mineral homeostasis?
What is the mechanism of action of bisphosphonates in treating osteoporosis?
What is the mechanism of action of bisphosphonates in treating osteoporosis?
What is the effect of food and other medications on the absorption of oral bisphosphonates?
What is the effect of food and other medications on the absorption of oral bisphosphonates?
What happens to bisphosphonates once they are bound to bone?
What happens to bisphosphonates once they are bound to bone?
Why should bisphosphonates be avoided in severe renal impairment?
Why should bisphosphonates be avoided in severe renal impairment?
What is the bioavailability of oral bisphosphonates?
What is the bioavailability of oral bisphosphonates?
What is the main treatment for osteoporosis?
What is the main treatment for osteoporosis?
What is the primary reason for the decline in bone density in postmenopausal osteoporosis?
What is the primary reason for the decline in bone density in postmenopausal osteoporosis?
Which of the following is a common adverse effect of oral bisphosphonates?
Which of the following is a common adverse effect of oral bisphosphonates?
What is the purpose of taking oral bisphosphonates on an empty stomach with a large quantity of water?
What is the purpose of taking oral bisphosphonates on an empty stomach with a large quantity of water?
What is the mechanism of action of raloxifene on bone?
What is the mechanism of action of raloxifene on bone?
What is the bioavailability of raloxifene after oral administration?
What is the bioavailability of raloxifene after oral administration?
What is the alternative treatment option for patients who are unable to tolerate oral bisphosphonates?
What is the alternative treatment option for patients who are unable to tolerate oral bisphosphonates?
What is the primary route of excretion for raloxifene?
What is the primary route of excretion for raloxifene?
Which of the following is a contraindication for the use of raloxifene?
Which of the following is a contraindication for the use of raloxifene?
What is the mechanism of action of parathyroid hormone analogs?
What is the mechanism of action of parathyroid hormone analogs?
What is the limitation of teriparatide therapy?
What is the limitation of teriparatide therapy?
What is the effect of low intermittent doses of parathyroid hormone?
What is the effect of low intermittent doses of parathyroid hormone?
What is the mechanism of action of denosumab?
What is the mechanism of action of denosumab?
What is the role of RANKL in osteoclast development?
What is the role of RANKL in osteoclast development?
What is the recommended administration frequency for denosumab?
What is the recommended administration frequency for denosumab?
Which of the following is a rare adverse effect of denosumab?
Which of the following is a rare adverse effect of denosumab?
What is the main preparation of calcitonin?
What is the main preparation of calcitonin?
What is a potential long-term risk associated with calcitonin use?
What is a potential long-term risk associated with calcitonin use?
Why was strontium recently withdrawn from the market?
Why was strontium recently withdrawn from the market?
