Osteopetrosis (Marble Bone Disease) Quiz
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Questions and Answers

What is the characteristic radiographic feature of Osteopetrosis?

  • Decreased skeletal density
  • Presence of bone cysts
  • Increased skeletal density with a marble-like appearance (correct)
  • Widening of skull foramina

What is the age range when Cherubism typically presents?

  • 5 to 10 years of age
  • 1 to 2 years of age
  • 10 to 15 years of age
  • 2 to 5 years of age (correct)

What is the oral manifestation of Osteopetrosis?

  • Increased risk of dental caries
  • Absence of osteoclasts
  • Early exfoliation of teeth
  • Failure of tooth eruption (correct)

What is the complication of Osteopetrosis that affects the hematopoietic system?

<p>All of the above (D)</p> Signup and view all the answers

What is the differential diagnosis of Osteopetrosis?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary reason for the blue sclera color in Osteogenesis Imperfecta Type I?

<p>Reduced collagen content in the sclera allowing pigmented choroid to show through (D)</p> Signup and view all the answers

Which of the following is a characteristic radiographic feature of Osteogenesis Imperfecta?

<p>Bowing of long bones (B)</p> Signup and view all the answers

What is the primary difference between Osteogenesis Imperfecta and Osteopetrosis?

<p>Bone density (D)</p> Signup and view all the answers

What is the outcome for most patients with Osteogenesis Imperfecta Type II?

<p>Death before 4 weeks of age (A)</p> Signup and view all the answers

What is the underlying cause of Osteopetrosis?

<p>Failure of osteoclastic bone resorption (D)</p> Signup and view all the answers

Which of the following congenital bone diseases is characterized by brittle bone that is prone to fracture?

<p>Osteogenesis imperfecta (D)</p> Signup and view all the answers

What is the primary cause of bone fragility in osteogenesis imperfecta?

<p>Mutation in COL1A1 and COL1A2 genes (B)</p> Signup and view all the answers

Which type of osteogenesis imperfecta is the most common and mildest form?

<p>Type I (B)</p> Signup and view all the answers

What is the characteristic feature of osteopetrosis?

<p>Abnormal bone density (C)</p> Signup and view all the answers

Which of the following is NOT a type of hereditary bone disease affecting endochondral bone?

<p>Osteoporosis (C)</p> Signup and view all the answers

What is the primary consequence of osteoporosis in the maxilla and/or mandible?

<p>Enhanced bone fragility (C)</p> Signup and view all the answers

Which congenital bone disorder is characterized by brittle bones that are prone to fracture?

<p>Osteogenesis Imperfecta (C)</p> Signup and view all the answers

What is the most significant factor in the prevention of osteoporosis?

<p>Regular exercise (A)</p> Signup and view all the answers

Which of the following is a characteristic of osteopetrosis?

<p>Impaired bone remodeling (C)</p> Signup and view all the answers

What is the primary focus of the lecture on osteoporosis and congenital bone disease?

<p>Clinical and histopathological features of congenital bone disease (D)</p> Signup and view all the answers

What is the primary genetic defect that leads to Cherubism?

<p>Mutations in the RUNX2 gene (C)</p> Signup and view all the answers

What is a characteristic oral manifestation of Cleidocranial Dysplasia?

<p>All of the above (D)</p> Signup and view all the answers

What is a common finding in radiographic examination of Cherubism patients?

<p>Bilateral, multilocular radiolucencies (C)</p> Signup and view all the answers

What is a characteristic feature of teeth in Cleidocranial Dysplasia patients?

<p>Enamel hypoplasia (A)</p> Signup and view all the answers

What is a common finding in the maxilla of Cleidocranial Dysplasia patients?

<p>Narrow and V-shaped with high arched palate (D)</p> Signup and view all the answers

What is the primary mechanism by which glucocorticoids contribute to bone loss?

<p>Stimulation of osteoclastic activity (D)</p> Signup and view all the answers

Which of the following is a consequence of mutation in COL1A1 and COL1A2 genes?

<p>Deficiency in type 1 collagen (D)</p> Signup and view all the answers

Heavy alcohol consumption can lead to bone loss and fracture due to which of the following mechanisms?

<p>Increased risk of falling and poor nutrition (B)</p> Signup and view all the answers

Which of the following medications is used to treat osteoporosis by inhibiting osteoclastic function and differentiation?

<p>Bisphosphonates (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of osteoporosis?

<p>Thin trabeculae disconnected from each other (B)</p> Signup and view all the answers

What is the primary cause of achondroplasia?

<p>Mutation in fibroblast growth factor 3 (FGFR3) on chromosome 4 (C)</p> Signup and view all the answers

What is the characteristic feature of the axial skeleton in achondroplasia?

<p>Normal development (A)</p> Signup and view all the answers

What is the oral manifestation of achondroplasia?

<p>Delayed dental development (B)</p> Signup and view all the answers

What is the definition of osteoporosis?

<p>A condition characterized by low bone mass (D)</p> Signup and view all the answers

What is the consequence of osteoporosis?

<p>Increased morbidity and mortality risks (C)</p> Signup and view all the answers

What is the impact of achondroplasia on intelligence?

<p>No impairment (A)</p> Signup and view all the answers

What is the characteristic feature of the extremities in achondroplasia?

<p>Short and thick (B)</p> Signup and view all the answers

What is the consequence of delayed dental development in achondroplasia?

<p>Delayed eruption of primary and permanent teeth (C)</p> Signup and view all the answers

What is the characteristic feature of the maxilla in achondroplasia?

<p>Hypoplasia (A)</p> Signup and view all the answers

What is the type of malocclusion associated with achondroplasia?

<p>Class III (C)</p> Signup and view all the answers

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