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Questions and Answers
What is the main pathogenic mechanism leading to bone changes in Primary Hyperparathyroidism?
What is the main pathogenic mechanism leading to bone changes in Primary Hyperparathyroidism?
- Increased osteoblast function
- Activation of osteoclasts leading to bone resorption (correct)
- Reduced osteoclast activity
- Decreased synthesis of active Vitamin D
Which term is used to describe the clinical presentation associated with Primary Hyperparathyroidism characterized by bone pain and fractures?
Which term is used to describe the clinical presentation associated with Primary Hyperparathyroidism characterized by bone pain and fractures?
- Osteomalacia
- Rickets
- Osteitis Cystica Fibrosa (correct)
- Hypocalcemia symptoms
What is the characteristic morphology seen in Osteitis Fibrosa Cystica?
What is the characteristic morphology seen in Osteitis Fibrosa Cystica?
- Increased osteoblast activity
- Vascularized tissue replacing calcified bone (correct)
- Bone marrow replacement by adipose tissue
- Reduced PTH levels
Which condition is often referred to as 'brown tumor' in the context of Hyperparathyroidism?
Which condition is often referred to as 'brown tumor' in the context of Hyperparathyroidism?
What type of infection is commonly associated with Pyogenic Osteomyelitis?
What type of infection is commonly associated with Pyogenic Osteomyelitis?
Which of the following is a characteristic feature seen on X-ray in Osteitis Cystica Fibrosa?
Which of the following is a characteristic feature seen on X-ray in Osteitis Cystica Fibrosa?
Which metabolic bone disease is characterized by unusually dense bones and calcium hydroxyapatite dissolution due to defective osteoclastic activity?
Which metabolic bone disease is characterized by unusually dense bones and calcium hydroxyapatite dissolution due to defective osteoclastic activity?
What genetic mutation is associated with Osteopetrosis (Marble bone disease)?
What genetic mutation is associated with Osteopetrosis (Marble bone disease)?
Which bone disease presents with broadened metaphysis resembling an Erlenmeyer flask on x-ray?
Which bone disease presents with broadened metaphysis resembling an Erlenmeyer flask on x-ray?
What is the characteristic clinical feature of the adult variant of Osteopetrosis?
What is the characteristic clinical feature of the adult variant of Osteopetrosis?
Which bone disease is associated with a severe infantile variant causing dense skull bones that can lead to vision loss and hearing loss?
Which bone disease is associated with a severe infantile variant causing dense skull bones that can lead to vision loss and hearing loss?
Which metabolic bone disease can be treated with a bone marrow transplant for the infantile variant?
Which metabolic bone disease can be treated with a bone marrow transplant for the infantile variant?
What is the mechanism by which SQSTM1 mutations stimulate NF-kB in the context of Paget Disease?
What is the mechanism by which SQSTM1 mutations stimulate NF-kB in the context of Paget Disease?
In Paget Disease, during which stage are abnormally large osteoclasts with an increased number of nuclei observed?
In Paget Disease, during which stage are abnormally large osteoclasts with an increased number of nuclei observed?
What is the most important finding in the morphology of Paget Disease during the sclerotic phase?
What is the most important finding in the morphology of Paget Disease during the sclerotic phase?
Which clinical feature is commonly associated with craniofacial involvement in Paget Disease?
Which clinical feature is commonly associated with craniofacial involvement in Paget Disease?
Avascular necrosis can occur in which bone of the hand?
Avascular necrosis can occur in which bone of the hand?
Which age group is commonly affected by Legg-Calve-Perthes disease?
Which age group is commonly affected by Legg-Calve-Perthes disease?
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