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Osteomalacia and Rickets in Renal Osteodystrophy

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18 Questions

What is the main pathogenic mechanism leading to bone changes in Primary Hyperparathyroidism?

Activation of osteoclasts leading to bone resorption

Which term is used to describe the clinical presentation associated with Primary Hyperparathyroidism characterized by bone pain and fractures?

Osteitis Cystica Fibrosa

What is the characteristic morphology seen in Osteitis Fibrosa Cystica?

Vascularized tissue replacing calcified bone

Which condition is often referred to as 'brown tumor' in the context of Hyperparathyroidism?

Osteitis Cystica Fibrosa

What type of infection is commonly associated with Pyogenic Osteomyelitis?

Bacterial infection

Which of the following is a characteristic feature seen on X-ray in Osteitis Cystica Fibrosa?

'Black spaces'

Which metabolic bone disease is characterized by unusually dense bones and calcium hydroxyapatite dissolution due to defective osteoclastic activity?

Osteopetrosis

What genetic mutation is associated with Osteopetrosis (Marble bone disease)?

Mutation in CA2 gene

Which bone disease presents with broadened metaphysis resembling an Erlenmeyer flask on x-ray?

Osteopetrosis

What is the characteristic clinical feature of the adult variant of Osteopetrosis?

Scoliosis

Which bone disease is associated with a severe infantile variant causing dense skull bones that can lead to vision loss and hearing loss?

Osteopetrosis

Which metabolic bone disease can be treated with a bone marrow transplant for the infantile variant?

Osteopetrosis

What is the mechanism by which SQSTM1 mutations stimulate NF-kB in the context of Paget Disease?

Activate RANK signaling

In Paget Disease, during which stage are abnormally large osteoclasts with an increased number of nuclei observed?

Initial osteolytic stage

What is the most important finding in the morphology of Paget Disease during the sclerotic phase?

Mosaic pattern of lamellar bone

Which clinical feature is commonly associated with craniofacial involvement in Paget Disease?

Platybasia

Avascular necrosis can occur in which bone of the hand?

Lunate bone

Which age group is commonly affected by Legg-Calve-Perthes disease?

4 to 10 years

Explore the differences between osteomalacia and rickets, focusing on bone weakening and growth plate thickening. Learn about the symptoms, risk factors, and pathogenesis of these bone disorders, particularly in the context of renal osteodystrophy.

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