18 Questions
What is the main pathogenic mechanism leading to bone changes in Primary Hyperparathyroidism?
Activation of osteoclasts leading to bone resorption
Which term is used to describe the clinical presentation associated with Primary Hyperparathyroidism characterized by bone pain and fractures?
Osteitis Cystica Fibrosa
What is the characteristic morphology seen in Osteitis Fibrosa Cystica?
Vascularized tissue replacing calcified bone
Which condition is often referred to as 'brown tumor' in the context of Hyperparathyroidism?
Osteitis Cystica Fibrosa
What type of infection is commonly associated with Pyogenic Osteomyelitis?
Bacterial infection
Which of the following is a characteristic feature seen on X-ray in Osteitis Cystica Fibrosa?
'Black spaces'
Which metabolic bone disease is characterized by unusually dense bones and calcium hydroxyapatite dissolution due to defective osteoclastic activity?
Osteopetrosis
What genetic mutation is associated with Osteopetrosis (Marble bone disease)?
Mutation in CA2 gene
Which bone disease presents with broadened metaphysis resembling an Erlenmeyer flask on x-ray?
Osteopetrosis
What is the characteristic clinical feature of the adult variant of Osteopetrosis?
Scoliosis
Which bone disease is associated with a severe infantile variant causing dense skull bones that can lead to vision loss and hearing loss?
Osteopetrosis
Which metabolic bone disease can be treated with a bone marrow transplant for the infantile variant?
Osteopetrosis
What is the mechanism by which SQSTM1 mutations stimulate NF-kB in the context of Paget Disease?
Activate RANK signaling
In Paget Disease, during which stage are abnormally large osteoclasts with an increased number of nuclei observed?
Initial osteolytic stage
What is the most important finding in the morphology of Paget Disease during the sclerotic phase?
Mosaic pattern of lamellar bone
Which clinical feature is commonly associated with craniofacial involvement in Paget Disease?
Platybasia
Avascular necrosis can occur in which bone of the hand?
Lunate bone
Which age group is commonly affected by Legg-Calve-Perthes disease?
4 to 10 years
Explore the differences between osteomalacia and rickets, focusing on bone weakening and growth plate thickening. Learn about the symptoms, risk factors, and pathogenesis of these bone disorders, particularly in the context of renal osteodystrophy.
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