Osteomalacia and Rickets in Renal Osteodystrophy
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main pathogenic mechanism leading to bone changes in Primary Hyperparathyroidism?

  • Increased osteoblast function
  • Activation of osteoclasts leading to bone resorption (correct)
  • Reduced osteoclast activity
  • Decreased synthesis of active Vitamin D
  • Which term is used to describe the clinical presentation associated with Primary Hyperparathyroidism characterized by bone pain and fractures?

  • Osteomalacia
  • Rickets
  • Osteitis Cystica Fibrosa (correct)
  • Hypocalcemia symptoms
  • What is the characteristic morphology seen in Osteitis Fibrosa Cystica?

  • Increased osteoblast activity
  • Vascularized tissue replacing calcified bone (correct)
  • Bone marrow replacement by adipose tissue
  • Reduced PTH levels
  • Which condition is often referred to as 'brown tumor' in the context of Hyperparathyroidism?

    <p>Osteitis Cystica Fibrosa</p> Signup and view all the answers

    What type of infection is commonly associated with Pyogenic Osteomyelitis?

    <p>Bacterial infection</p> Signup and view all the answers

    Which of the following is a characteristic feature seen on X-ray in Osteitis Cystica Fibrosa?

    <p>'Black spaces'</p> Signup and view all the answers

    Which metabolic bone disease is characterized by unusually dense bones and calcium hydroxyapatite dissolution due to defective osteoclastic activity?

    <p>Osteopetrosis</p> Signup and view all the answers

    What genetic mutation is associated with Osteopetrosis (Marble bone disease)?

    <p>Mutation in CA2 gene</p> Signup and view all the answers

    Which bone disease presents with broadened metaphysis resembling an Erlenmeyer flask on x-ray?

    <p>Osteopetrosis</p> Signup and view all the answers

    What is the characteristic clinical feature of the adult variant of Osteopetrosis?

    <p>Scoliosis</p> Signup and view all the answers

    Which bone disease is associated with a severe infantile variant causing dense skull bones that can lead to vision loss and hearing loss?

    <p>Osteopetrosis</p> Signup and view all the answers

    Which metabolic bone disease can be treated with a bone marrow transplant for the infantile variant?

    <p>Osteopetrosis</p> Signup and view all the answers

    What is the mechanism by which SQSTM1 mutations stimulate NF-kB in the context of Paget Disease?

    <p>Activate RANK signaling</p> Signup and view all the answers

    In Paget Disease, during which stage are abnormally large osteoclasts with an increased number of nuclei observed?

    <p>Initial osteolytic stage</p> Signup and view all the answers

    What is the most important finding in the morphology of Paget Disease during the sclerotic phase?

    <p>Mosaic pattern of lamellar bone</p> Signup and view all the answers

    Which clinical feature is commonly associated with craniofacial involvement in Paget Disease?

    <p>Platybasia</p> Signup and view all the answers

    Avascular necrosis can occur in which bone of the hand?

    <p>Lunate bone</p> Signup and view all the answers

    Which age group is commonly affected by Legg-Calve-Perthes disease?

    <p>4 to 10 years</p> Signup and view all the answers

    More Like This

    Vitamin E and Osteomalacia Quiz
    20 questions
    Osteomalacia y Osteoporosis
    40 questions
    Rickets and Osteomalacia Quiz
    36 questions
    Use Quizgecko on...
    Browser
    Browser