Osteoarthritis seminar

<p>Platelet-rich plasma (PRP). (C)</p> Signup and view all the answers

<p>Inhibition of COX-3 at the CNS level. (D)</p> Signup and view all the answers

<p>Encourages formation of growth factors through activated platelets (C)</p> Signup and view all the answers

<p>RTX functions by activating the vanilloid receptor 1 involved in nociception (D)</p> Signup and view all the answers

<p>It remains effective from 1 to 6 months depending on MW and enzyme activity (C)</p> Signup and view all the answers

<p>Its autologous nature leads to low incidence of infections and inflammation (D)</p> Signup and view all the answers

<p>HA has unique antiangiogenic and tissue repair-promoting properties (A)</p> Signup and view all the answers

<p>It is a prodrug that is converted to an active metabolite Rhein. (A)</p> Signup and view all the answers

<p>Diarrhea (C)</p> Signup and view all the answers

<p>It acts as a lubricant and is a main component of synovial fluid. (B)</p> Signup and view all the answers

<p>It increases both analgesic and anti-inflammatory effects. (B)</p> Signup and view all the answers

<p>It directly inhibits IL-1β and modulates the inflammatory cascade. (C)</p> Signup and view all the answers

<p>Centrally acting μ-agonist and SNRI (C)</p> Signup and view all the answers

<p>Tramadol (D)</p> Signup and view all the answers

<p>Gastro-lesive effects (C)</p> Signup and view all the answers

<p>Intra-articular corticosteroids (C)</p> Signup and view all the answers

<p>Gastrointestinal bleeding (B)</p> Signup and view all the answers

<p>Inhibition of inflammatory mediators (D)</p> Signup and view all the answers

<p>Meloxicam (B)</p> Signup and view all the answers

<p>Hypotension (B)</p> Signup and view all the answers

<p>Imbalance in cartilage matrix synthesis and degradation (C)</p> Signup and view all the answers

<p>It is more common in women than in men, particularly after age 60. (C)</p> Signup and view all the answers

<p>They are the primary producers of collagen and hyaluronic acid. (C)</p> Signup and view all the answers

<p>Pain, bone deformation, and loss of joint function. (C)</p> Signup and view all the answers

<p>Reduction of working days. (C)</p> Signup and view all the answers

<p>It causes activation of degradative enzymes and proinflammatory mediators. (A)</p> Signup and view all the answers

<p>Osteoarthritis results from mechanical stress and cartilage degradation rather than autoimmune factors. (B)</p> Signup and view all the answers

<p>Has a high cellularity (B)</p> Signup and view all the answers

<p>Reduction of catabolic activity of chondrocytes (A)</p> Signup and view all the answers

<p>SYSADOA maintains effect even for months after treatment withdrawal (B)</p> Signup and view all the answers

<p>It is an amino-monosaccharide important in cartilage biosynthesis (B)</p> Signup and view all the answers

<p>Immunosuppression and increased possibility of infection (C)</p> Signup and view all the answers

<p>Enhances synovial fluid viscosity to improve joint function (B)</p> Signup and view all the answers

<p>They are typically slow-acting but have long-term benefits (C)</p> Signup and view all the answers

<p>Tumor necrosis factor-alpha and interleukin-1beta (C)</p> Signup and view all the answers

<p>Can be administered orally or intra-articularly (C)</p> Signup and view all the answers

A type of medication that relieves pain without reducing inflammation. It's commonly used for mild osteoarthritis.

A group of drugs that target a specific enzyme (COX-3) in the central nervous system (CNS) to reduce pain.

The process by which the body breaks down and removes drugs, usually in the liver.

A drug target, a protein that catalyzes chemical transformations in the body.

An extremely toxic metabolite of paracetamol that can lead to liver failure if not neutralized.

A type of opioid used to manage moderate to severe osteoarthritis pain. It works by stimulating opioid receptors in the brain, decreasing pain signals and potentially affecting mood.

A class of drugs that block the production of prostaglandins, reducing inflammation and pain. Examples include diclofenac, aceclofenac, piroxicam, and meloxicam.

A specific type of NSAID that selectively inhibits COX-2, an enzyme involved in inflammation. It's often used for its pain-relieving properties.

A group of medications that have powerful anti-inflammatory and immunosuppressive properties. They are directly injected into joints to control inflammation and pain.

The process of reducing pain signals and inflammation in the body using medications.

A category of treatment used to manage osteoarthritis that involves medications like tramadol and NSAIDs.

Osteoarthritis is a chronic, degenerative joint disorder that causes pain, stiffness, and loss of joint function.

Osteoarthritis is characterized by progressive cartilage breakdown, leading to inflammation and pain. This process can cause significant disability.

Osteoarthritis is a disease that affects the joints, primarily the cartilage. Cartilage is a type of connective tissue that helps to cushion and protect the bones.

Osteoarthritis is different from rheumatoid arthritis, which is an autoimmune disease. Osteoarthritis is primarily caused by mechanical wear-and-tear of the joints, while rheumatoid arthritis is caused by an immune response that attacks the joints.

Osteoarthritis is more common in women than in men, especially after the age of 60. It is the 6th leading cause of disability globally.

Osteoarthritis is caused by an imbalance in the production and breakdown of the extracellular matrix of cartilage, leading to chronic inflammation. Mechanical stress on the joints can contribute to this imbalance.

Articular cartilage is a type of connective tissue that covers the ends of bones in a joint. It is composed of cells called chondrocytes that produce and maintain the extracellular matrix of cartilage.

Chondrocytes and synovial cells are key players in maintaining the health of joints. They both produce collagen and hyaluronic acid, which are essential for cartilage function.

Drugs that slow down the progression of osteoarthritis, particularly helpful in reducing pain and improving joint function.

SYSADOAs are generally considered to work by promoting the synthesis of proteoglycans, which are essential components of cartilage, while inhibiting the breakdown of cartilage.

Chondroitin sulfate is a sugar molecule that is a key component of cartilage, helping to give it its structure and flexibility.

Glucosamine is a naturally occurring amino sugar that plays a vital role in the production of cartilage.

Chondroitin sulfate and glucosamine work together to support the health of cartilage and slow down the progression of osteoarthritis.

Diacerein is an oral medication that helps to reduces inflammation and pain in the joints affected by osteoarthritis.

Hyaluronic acid is a natural substance found in the joints that helps to lubricate and cushion cartilage. Viscosupplementation involves injecting hyaluronic acid into the joint to restore lubrication.

SYSADOAs are generally considered to be safe and well-tolerated, with few side effects.

A synthetic drug that combines chondroitin sulfate and glucosamine. It's used to treat osteoarthritis, potentially helping to rebuild cartilage and reduce inflammation. It takes a few weeks for it to start working and can stay effective for a while after stopping the treatment, although the exact way it works is unclear.

A group of drugs used to treat osteoarthritis that work by modifying the disease process, often by reducing inflammation and protecting cartilage.

A drug that works by slowing down the inflammatory process in the joints. It's a prodrug, meaning it's transformed into its active form (rhein) inside the body. Diacerein can take a few weeks to start working and its effects can last for a few months even after stopping the treatment.

A vital component of synovial fluid, providing lubrication and shock absorption to joints. In osteoarthritis, hyaluronic acid can get broken down, leading to reduced joint lubrication and increased risk of damage.

A type of medicine that involves injecting hyaluronic acid directly into the joint space. This can help to improve lubrication and cushioning in osteoarthritic joints.

A blood-derived product containing a high concentration of platelets. When activated, platelets release growth factors that stimulate tissue regeneration and repair.

A naturally occurring capsaicin analog used to treat pain associated with osteoarthritis (OA). It works by targeting sensory neurons involved in pain perception.

A receptor found on certain sensory neurons that is activated by capsaicin and RTX, contributing to pain sensation.

A type of medication that does not belong to the opioid family. Examples include RTX, which is currently in Phase III trials for OA pain.