Osmotic Diuretics: Mechanism and Effects

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Questions and Answers

What is the main effect of prolonged use of mannitol beyond a urine volume of 100 mL/hr?

  • Increase intracellular volume
  • Decrease extracellular volume
  • Alter Starling forces causing water to leave cells (correct)
  • Promote dehydration

Which adverse effect is associated with osmotic diuretics?

  • Hypernatremia (correct)
  • Hypocalcemia
  • Hypokalemia
  • Hypertension

Which condition can be treated by the use of mannitol to reduce intracranial pressure?

  • Hyperthyroidism
  • Neurologic conditions (correct)
  • Heart failure
  • Hypertension

What is the primary function of antidiuretic hormone (ADH) in the body?

<p>Regulate body's water balance (A)</p> Signup and view all the answers

'Desmopressin' is useful in treating which condition related to antidiuretic hormone (ADH)?

<p>Neurogenic diabetes insipidus (D)</p> Signup and view all the answers

Where do osmotic diuretics act in the kidney?

<p>Ascending limb of the loop of Henle (D)</p> Signup and view all the answers

How are osmotic diuretics excreted from the body?

<p>Excreted by glomerular filtration (B)</p> Signup and view all the answers

Which drug is considered an ADH antagonist?

<p>Conivaptan (C)</p> Signup and view all the answers

Which drug is considered the prototype of osmotic diuretics?

<p>Mannitol (B)</p> Signup and view all the answers

What is the effect of osmotic diuretics on Na+ excretion?

<p>Increases Na+ excretion (A)</p> Signup and view all the answers

What is a clinical application of Mannitol?

<p>Maintenance of urine volume in anuria (C)</p> Signup and view all the answers

Which condition would benefit from treatment with Mannitol as an osmotic diuretic?

<p>Acute glaucoma (C)</p> Signup and view all the answers

Which type of diuretic remains in the lumen and 'holds' water by virtue of their osmotic effect?

<p>Osmotic diuretics (D)</p> Signup and view all the answers

What is the main adverse effect associated with potassium-sparing diuretics?

<p>Hyperkalemia (B)</p> Signup and view all the answers

Which of the following is NOT an adverse effect associated with spironolactone or eplerenone?

<p>Hypokalemia (D)</p> Signup and view all the answers

Which condition can be effectively treated with potassium-sparing diuretics like spironolactone?

<p>Hyperaldosteronism (C)</p> Signup and view all the answers

Which diuretic has been shown to reduce myocardial perfusion defects after a myocardial infarction, leading to a 15% decrease in mortality rate?

<p>Eplerenone (D)</p> Signup and view all the answers

What is the mode of action of osmotic diuretics?

<p>Staying in the lumen and holding water osmotically (B)</p> Signup and view all the answers

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