5 Questions
- What are the functions of the HA and NA proteins in the envelope of Influenza viruses?
The hemagglutinin (HA) protein binds to the cell surface receptor (sialic acid) to initiate infection and is the target of neutralizing antibodies. The neuraminidase (NA) protein cleaves neuraminic acid (sialic acid) to release progeny virus from the infected cell.
- What is the genome type of Orthomyxoviruses and where does replication occur?
Orthomyxoviruses have a single-stranded RNA genome, segmented into eight molecules, with negative sense polarity. Replication occurs in the nucleus of the infected cell.
- What is the function of the M2 protein in the Influenza virus?
The M2 protein is an integral membrane protein that is essential for virus uncoating.
- What is the role of the Matrix (M1) protein in the Influenza virus envelope?
The Matrix (M1) protein lines the inside of the envelope and is involved in the assembly of the virus.
- What are the three large proteins in the Influenza virus and their functions?
The three large proteins in the Influenza virus are PB1, PB2, and PA. PB1 is responsible for RNA transcription and replication, PB2 is bound to the viral NP and also involved in RNA transcription and replication, and PA is associated with RNA and polymerase proteins.
Test your knowledge of Orthomyxoviruses, specifically Influenza viruses, their structure, genome, and important properties.
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