20 Questions
Which type of virus is Thogotovirus?
Transmitted by ticks
What distinguishes multiple subtypes within each virus type of Orthomyxoviridae?
Variations in surface glycoproteins HA and NA
How does Influenza virus infections of the respiratory tract lead to secondary bacterial infections?
Loss of the ciliated epithelium and disruption of mucociliary flow
What is the origin of the envelope in Myxoviruses?
Derived from host-membrane by budding
What is the diameter range of enveloped particles of Myxoviruses?
~80-120nm
What is the function of hemagglutinin (HA) and neuraminidase (NA) in Orthomyxoviridae?
Surface glycoproteins distinguishing multiple subtypes within each virus type
What are the additional genera within Orthomyxoviridae, besides paramyxo and orthomyxo?
Thogotovirus (transmitted by ticks) and Isavirus (infects fish)
What are the symptoms associated with Influenza virus infections?
High fever, sore throat, cough, headache, muscular pain
Who is most at risk of fatal outcomes from Influenza virus infections?
Elderly, infants, and chronically ill individuals
What leads to easier access for secondary bacterial infections during Influenza virus infections?
Virus-induced loss of the ciliated epithelium and disruption of mucociliary flow
What is the origin of the envelope in Myxoviruses?
Derived from host-membrane by budding
What is the structure of the nucleocapsid in Myxoviruses?
Compact helical nucleocapsid
What are the two surface glycoproteins that distinguish subtypes within each virus type of Orthomyxoviridae?
Hemagglutinin (HA) and neuraminidase (NA)
How do Influenza virus infections lead to local and systemic inflammatory responses?
By inducing production of interferons and cytokines
What distinguishes the multiple subtypes within each virus type of Orthomyxoviridae?
Variations in the surface glycoproteins: hemagglutinin (HA) and neuraminidase (NA)
What is the structure of the nucleocapsid in Myxoviruses?
Compact helical
What is the origin of the envelope in Myxoviruses?
Derived from host-membrane by budding
Which type of virus is Thogotovirus?
Transmitted by ticks
What leads to easier access for secondary bacterial infections during Influenza virus infections?
Virus-induced loss of ciliated epithelium and disruption of mucociliary flow
What are the symptoms associated with Influenza virus infections?
High fever, sore throat, cough, headache, muscular pain
Test your knowledge about the Orthomyxoviridae family and its characteristics, including structure, replication cycles, and subtypes. Learn about the envelope derived from the host membrane and the distinctive features of this virus family.
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