Oral Drug Absorption Factors Quiz
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Questions and Answers

What is the most common mechanism of drug absorption?

  • Passive non-ionic diffusion (correct)
  • Facilitated diffusion
  • Osmosis
  • Active transport

Which factor does not influence drug absorption?

  • Molecular size
  • Degree of ionization
  • Lipid solubility
  • Temperature (correct)

What is the process where the drug dissolves in a solvent?

  • Dissolution (correct)
  • Osmosis
  • Diffusion
  • Absorption

Which dosage forms are exempt from the disintegration requirement?

<p>Troches and chewable tablets (C)</p> Signup and view all the answers

What is the most common dissolution testing apparatus described in USP chapter for oral drug absorption?

<p>Apparatus 1 and Apparatus 2 (D)</p> Signup and view all the answers

What is the pH range of the dissolution medium for oral drug absorption testing?

<p>1.2 – 6.8 (A)</p> Signup and view all the answers

What is the rate-limiting step for low water soluble (hydrophobic) drugs in terms of oral drug absorption?

<p>Dissolution (C)</p> Signup and view all the answers

Which oral dosage form exhibits the most rapid absorption of all oral dosage forms?

<p>Solutions (A)</p> Signup and view all the answers

What is the primary distinguishing feature of controlled-release solid dosage forms?

<p>Efficient dosage form with a shell that holds the drug formulation (C)</p> Signup and view all the answers

What does bioavailability indicate for oral products?

<p>The fractional extent to which a dose of drug reaches the site of action (C)</p> Signup and view all the answers

What are the three indices of bioavailability?

<p>Cmax, tmax, AUC (A)</p> Signup and view all the answers

What does bioequivalence refer to?

<p>Describing the bioavailability of the same drug in two different formulations (C)</p> Signup and view all the answers

What is the primary focus of the Biopharmaceutics Classification System (BCS)?

<p>Solubility and permeability (B)</p> Signup and view all the answers

What is the most common range for the dissolution medium pH in oral drug absorption testing?

<p>1.2 – 6.8 (C)</p> Signup and view all the answers

What is the rate-limiting step for high water soluble (hydrophilic) drugs in terms of oral drug absorption?

<p>Permeability (B)</p> Signup and view all the answers

What is the primary consideration for solid dosage forms to exhibit efficient drug absorption?

<p>Shell must release the drug particles before absorption can take place (A)</p> Signup and view all the answers

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