Oral Drug Absorption Factors Quiz
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Questions and Answers

What is the most common mechanism of drug absorption?

  • Passive non-ionic diffusion (correct)
  • Facilitated diffusion
  • Osmosis
  • Active transport
  • Which factor does not influence drug absorption?

  • Molecular size
  • Degree of ionization
  • Lipid solubility
  • Temperature (correct)
  • What is the process where the drug dissolves in a solvent?

  • Dissolution (correct)
  • Osmosis
  • Diffusion
  • Absorption
  • Which dosage forms are exempt from the disintegration requirement?

    <p>Troches and chewable tablets</p> Signup and view all the answers

    What is the most common dissolution testing apparatus described in USP chapter for oral drug absorption?

    <p>Apparatus 1 and Apparatus 2</p> Signup and view all the answers

    What is the pH range of the dissolution medium for oral drug absorption testing?

    <p>1.2 – 6.8</p> Signup and view all the answers

    What is the rate-limiting step for low water soluble (hydrophobic) drugs in terms of oral drug absorption?

    <p>Dissolution</p> Signup and view all the answers

    Which oral dosage form exhibits the most rapid absorption of all oral dosage forms?

    <p>Solutions</p> Signup and view all the answers

    What is the primary distinguishing feature of controlled-release solid dosage forms?

    <p>Efficient dosage form with a shell that holds the drug formulation</p> Signup and view all the answers

    What does bioavailability indicate for oral products?

    <p>The fractional extent to which a dose of drug reaches the site of action</p> Signup and view all the answers

    What are the three indices of bioavailability?

    <p>Cmax, tmax, AUC</p> Signup and view all the answers

    What does bioequivalence refer to?

    <p>Describing the bioavailability of the same drug in two different formulations</p> Signup and view all the answers

    What is the primary focus of the Biopharmaceutics Classification System (BCS)?

    <p>Solubility and permeability</p> Signup and view all the answers

    What is the most common range for the dissolution medium pH in oral drug absorption testing?

    <p>1.2 – 6.8</p> Signup and view all the answers

    What is the rate-limiting step for high water soluble (hydrophilic) drugs in terms of oral drug absorption?

    <p>Permeability</p> Signup and view all the answers

    What is the primary consideration for solid dosage forms to exhibit efficient drug absorption?

    <p>Shell must release the drug particles before absorption can take place</p> Signup and view all the answers

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