Podcast
Questions and Answers
What is the mechanism of action of sulfonamides in bacteria?
What is the mechanism of action of sulfonamides in bacteria?
- Substituting PABA needed for folate formation (correct)
- Inhibiting DNA gyrase
- Enhancing protein synthesis
- Blocking the binding of trimethoprim
Why are side chains useful in sulfonamides?
Why are side chains useful in sulfonamides?
- To substitute for PABA in bacterial protein synthesis
- To aid in the formation of folate required for protein synthesis (correct)
- To enhance the solubility of sulfonamides at acidic pH
- To prevent bacteria from recognizing sulfonamides as PABA
What cellular events are initiated by osteoclastic bone resorption and followed by osteoblastic bone formation?
What cellular events are initiated by osteoclastic bone resorption and followed by osteoblastic bone formation?
- Bacterial resistance to sulfonamides
- Synthesis of sulfonamides
- Production of purines
- Formation of new bone tissue (correct)
Which organisms are susceptible to sulfonamides' inhibition of dihydropteroate synthase?
Which organisms are susceptible to sulfonamides' inhibition of dihydropteroate synthase?
Why is Pseudomonas aeruginosa resistant to sulfonamide antibiotics?
Why is Pseudomonas aeruginosa resistant to sulfonamide antibiotics?
What do sulfonamides inhibit to disrupt the production of folate?
What do sulfonamides inhibit to disrupt the production of folate?
In which pH conditions are sulfonamides more soluble?
In which pH conditions are sulfonamides more soluble?
What is the mechanism of action of pyrimethamine when combined with sulfadoxine?
What is the mechanism of action of pyrimethamine when combined with sulfadoxine?
Which condition is Sulfasalazine commonly used for?
Which condition is Sulfasalazine commonly used for?
How are sulfonamides and their inactive metabolites mainly excreted?
How are sulfonamides and their inactive metabolites mainly excreted?
What is the role of sodium sulfacetamide in topical treatment?
What is the role of sodium sulfacetamide in topical treatment?
In which conditions is mafenide acetate used topically?
In which conditions is mafenide acetate used topically?
Which sulfonamide is preferred over mafenide acetate for preventing infection of burn wounds?
Which sulfonamide is preferred over mafenide acetate for preventing infection of burn wounds?
What is the drug of choice for infections like Pneumocystis jiroveci pneumonia?
What is the drug of choice for infections like Pneumocystis jiroveci pneumonia?
What can cause sulfonamide resistance due to overproduction of PABA?
What can cause sulfonamide resistance due to overproduction of PABA?
What is the first-line therapy for the treatment of Acute Toxoplasmosis?
What is the first-line therapy for the treatment of Acute Toxoplasmosis?
Which drug combination blocks sequential steps in the folate synthesis pathway?
Which drug combination blocks sequential steps in the folate synthesis pathway?
Which oral agent is used as a 2nd line treatment for Malaria?
Which oral agent is used as a 2nd line treatment for Malaria?
Which topical agent is effective in the treatment of bacterial conjunctivitis?
Which topical agent is effective in the treatment of bacterial conjunctivitis?
In which condition is Sulfasalazine widely used?
In which condition is Sulfasalazine widely used?
What is a particularly serious and potentially fatal type of skin and mucous membrane eruption associated with sulfonamide use?
What is a particularly serious and potentially fatal type of skin and mucous membrane eruption associated with sulfonamide use?
Which adverse effect of sulfonamides can lead to kidney failure and potentially be fatal?
Which adverse effect of sulfonamides can lead to kidney failure and potentially be fatal?
What is the recommended treatment for crystalluria caused by sulfonamides?
What is the recommended treatment for crystalluria caused by sulfonamides?
Which condition can sulfonamides provoke in patients with glucose-6-phosphate dehydrogenase deficiency?
Which condition can sulfonamides provoke in patients with glucose-6-phosphate dehydrogenase deficiency?
In which condition may sulfonamides cause hemolytic or aplastic anemia?
In which condition may sulfonamides cause hemolytic or aplastic anemia?
Which adverse effect of sulfonamides is treated by increasing urine flow?
Which adverse effect of sulfonamides is treated by increasing urine flow?
What is the agent of choice for moderately severe to severe pneumocystis pneumonia?
What is the agent of choice for moderately severe to severe pneumocystis pneumonia?
Which adverse effect is not associated with trimethoprim among the adverse effects of TMP-SMX?
Which adverse effect is not associated with trimethoprim among the adverse effects of TMP-SMX?
What is the potential consequence of trimethoprim inhibiting creatinine secretion at the distal renal tubule?
What is the potential consequence of trimethoprim inhibiting creatinine secretion at the distal renal tubule?
Which condition may be effectively treated using oral pyrimethamine with a sulfonamide combination?
Which condition may be effectively treated using oral pyrimethamine with a sulfonamide combination?
What are some untoward reactions associated with the combination of trimethoprim-sulfamethoxazole with sulfonamides?
What are some untoward reactions associated with the combination of trimethoprim-sulfamethoxazole with sulfonamides?
How does trimethoprim inhibit bacterial growth?
How does trimethoprim inhibit bacterial growth?
What is a common mechanism of resistance to trimethoprim?
What is a common mechanism of resistance to trimethoprim?
How is trimethoprim excreted from the body?
How is trimethoprim excreted from the body?
What impact does kidney disease have on trimethoprim dosage?
What impact does kidney disease have on trimethoprim dosage?
Which area of the body does trimethoprim show better antibacterial activity in due to its acidity?
Which area of the body does trimethoprim show better antibacterial activity in due to its acidity?
When is oral trimethoprim commonly used alone?
When is oral trimethoprim commonly used alone?
Which fluoroquinolone is considered the drug of choice in multi-drug resistant TB?
Which fluoroquinolone is considered the drug of choice in multi-drug resistant TB?
What causes emerging resistance to fluoroquinolones?
What causes emerging resistance to fluoroquinolones?
What is a key feature of Levofloxacin that results in its high dose and short course administration?
What is a key feature of Levofloxacin that results in its high dose and short course administration?
Which organisms are fluoroquinolones active against, besides gram-positive bacteria?
Which organisms are fluoroquinolones active against, besides gram-positive bacteria?
What does resistance to one fluoroquinolone generally confer to other members of the class?
What does resistance to one fluoroquinolone generally confer to other members of the class?
Why are Gatifloxacin, Gemifloxacin, and Moxifloxacin considered part of the latest group of fluoroquinolones?
Why are Gatifloxacin, Gemifloxacin, and Moxifloxacin considered part of the latest group of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
Which fluoroquinolone is known for its superior activity against gram-positive organisms?
Which fluoroquinolone is known for its superior activity against gram-positive organisms?
What is the primary reason for using fluoroquinolones in combination with a second active agent when treating staphylococcal infections?
What is the primary reason for using fluoroquinolones in combination with a second active agent when treating staphylococcal infections?
Which fluoroquinolone is considered the least active against both gram-negative and gram-positive organisms?
Which fluoroquinolone is considered the least active against both gram-negative and gram-positive organisms?
Which group of fluoroquinolones possess excellent gram-negative activity and moderate to good activity against gram-positive bacteria?
Which group of fluoroquinolones possess excellent gram-negative activity and moderate to good activity against gram-positive bacteria?
What is the recommended timing for taking oral fluoroquinolones in relation to products containing divalent and trivalent cations?
What is the recommended timing for taking oral fluoroquinolones in relation to products containing divalent and trivalent cations?
Which fluoroquinolone does not require dosage adjustment for renal failure due to its metabolism in the liver?
Which fluoroquinolone does not require dosage adjustment for renal failure due to its metabolism in the liver?
Which fluoroquinolone is considered effective in urinary tract infections caused by Pseudomonas aeruginosa?
Which fluoroquinolone is considered effective in urinary tract infections caused by Pseudomonas aeruginosa?
For which type of infections are fluoroquinolones (except norfloxacin) commonly used?
For which type of infections are fluoroquinolones (except norfloxacin) commonly used?
Which fluoroquinolone is specifically mentioned as the drug of choice for prophylaxis and treatment of Anthrax?
Which fluoroquinolone is specifically mentioned as the drug of choice for prophylaxis and treatment of Anthrax?
In which condition are Levofloxacin and Ofloxacin recommended as alternative treatment options?
In which condition are Levofloxacin and Ofloxacin recommended as alternative treatment options?
What is a common side effect associated with Fluoroquinolones?
What is a common side effect associated with Fluoroquinolones?
Which factor is identified as a risk factor for tendinitis associated with Fluoroquinolones?
Which factor is identified as a risk factor for tendinitis associated with Fluoroquinolones?
What is a potential complication that can occur with Gatifloxacin, Levofloxacin, Gemifloxacin, and Moxifloxacin use?
What is a potential complication that can occur with Gatifloxacin, Levofloxacin, Gemifloxacin, and Moxifloxacin use?
When should Fluoroquinolones be avoided in relation to pregnancy?
When should Fluoroquinolones be avoided in relation to pregnancy?
Which type of infection do Levofloxacin, Gemifloxacin, and Moxifloxacin effectively treat?
Which type of infection do Levofloxacin, Gemifloxacin, and Moxifloxacin effectively treat?
What is a condition in which Fluoroquinolones should be used with caution due to potential complications?
What is a condition in which Fluoroquinolones should be used with caution due to potential complications?
