Opioids and Psychedelics Quiz
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Questions and Answers

What is opium?

A chemical compound extracted from the seed pods of opium poppy plants.

What are opioids?

Substances that contain opium or its psychoactive constituents or chemically similar drugs

What is a synthetic opioid?

A synthetically produced drug chemically similar to naturally occurring opioids.

What is the problem with the increasing use of fentanyl?

<p>Heroin is being cut with increasingly larger amounts of fentanyl.</p> Signup and view all the answers

What is the most potent commercially available opioid?

<p>Carfentanil</p> Signup and view all the answers

Opioids are responsible for 25 percent of death certificates related to overdose deaths.

<p>True</p> Signup and view all the answers

Who made an evaluation of drug dangerousness?

<p>David Nutt</p> Signup and view all the answers

Psychedelic drugs are considered more dangerous than legal and illegal drugs.

<p>False</p> Signup and view all the answers

Who coined the term "psychedelic"?

<p>Humphry Osmond</p> Signup and view all the answers

What was the name of the mental hospital where Osmond worked?

<p>Weyburn Mental Hospital</p> Signup and view all the answers

Who was Osmond's director of research?

<p>Abram Hoffer</p> Signup and view all the answers

What was Albert Hofmann looking for when he produced LSD-25?

<p>New medicine</p> Signup and view all the answers

LSD-25 was the 25th chemical that Hofmann produced in a series of lysergic acid compounds.

<p>True</p> Signup and view all the answers

Hofmann's first experience with LSD happened on April 16, 1943.

<p>True</p> Signup and view all the answers

What did Hofmann experience after ingesting LSD?

<p>Intense, kaleidoscopic play of colors in fantastic pictures, extraordinary shapes</p> Signup and view all the answers

Hofmann believed that some of the LSD had been absorbed through his fingertips during the crystallization process.

<p>True</p> Signup and view all the answers

What is Bicycle Day?

<p>The day when Hofmann rode his bicycle home after taking LSD, unaware of its potency</p> Signup and view all the answers

What happened to Hofmann after taking a large dose of LSD?

<p>He felt like he was outside of his body. He experienced grotesque, threatening forms of familiar objects. He was unsure if he was dying.</p> Signup and view all the answers

Hofmann believed that LSD could be useful in psychiatry.

<p>True</p> Signup and view all the answers

How many papers about LSD had been published by 1960?

<p>More than 500</p> Signup and view all the answers

What happened to John Lilly when he took LSD while in an isolation tank?

<p>He felt terrified and he could not feel his body or brain. He felt a small point of consciousness in a vast domain.</p> Signup and view all the answers

What was the name of the first article concerning LSD?

<p>Phantasticum</p> Signup and view all the answers

The term "world illusion genic" has been proposed as an alternative to hallucinogens.

<p>True</p> Signup and view all the answers

Psychedelic drugs are psychotropic in the sense that they are mind-altering.

<p>True</p> Signup and view all the answers

Psycholytic means mind dissolving.

<p>True</p> Signup and view all the answers

Psychedelic drugs that appear to provide extrasensory empowerment are called telepathines.

<p>True</p> Signup and view all the answers

What happened to Timothy Leary when he took psychedelic drugs for the first time?

<p>He had a religious experience and felt that he had awakened from a long ontological sleep.</p> Signup and view all the answers

What does "turning on" refer to?

<p>Awakening from a long ontological sleep</p> Signup and view all the answers

What does "dropping out" refer to?

<p>The pursuit of an authentic spiritual quest</p> Signup and view all the answers

Leary believed that psychedelic drugs could liberate people from the games of life.

<p>True</p> Signup and view all the answers

By the late 1960s, psychedelic drugs had spawned a counterculture with characteristic lifestyles, leaders, status distinctions, and internal rivalries.

<p>True</p> Signup and view all the answers

Those who used LSD were charged with being sick and dangerous.

<p>True</p> Signup and view all the answers

What did drug advocates reply when they were accused of being sick and dangerous?

<p>They said that the authorities were sick and dangerous.</p> Signup and view all the answers

Medical personnel and lawmakers were accused of approving enslaving drugs such as alcohol and nicotine but prohibiting the liberating psychedelics.

<p>True</p> Signup and view all the answers

LSD had become the sacrament that provided anyone who wanted them with visionary experiences that had previously been the property of solitary mystics and esoteric collectives?

<p>True</p> Signup and view all the answers

Who introduced psychedelics to a group of artists, engineers, architects, and scientists in the San Francisco Bay area?

<p>James Fadiman</p> Signup and view all the answers

Participants reported experiencing mental fluidity, increased ability to visualize and recontextualize problems, and crediting LSD for contributing to the birth of the computer revolution.

<p>True</p> Signup and view all the answers

Osmond traveled to Leary to say that he was doing something dangerous, and Osmond tried renaming the psychedelics by introducing the neologism "psychedelic" to distance legitimate research from the frivolous use of psychedelics.

<p>True</p> Signup and view all the answers

LSD was available to physicians until 1963 and its availability was restricted in 1966. Possession of LSD became illegal throughout the United States in 1968. The Comprehensive Drug Abuse Prevention and Control Act was put in place in 1970.

<p>True</p> Signup and view all the answers

The Comprehensive Drug Abuse Prevention and Control Act classified many psychedelics as Schedule I controlled drugs, meaning the drug has high abuse potential, no current accepted medical use, and a lack of safety, even with medical supervision.

<p>True</p> Signup and view all the answers

A study in 1990 found that 77 percent of Tibetan Buddhist practitioners reported previous experiences with major psychedelics, and 32 percent claimed that major psychedelics had contributed to attracting them to Tibetan Buddhism.

<p>True</p> Signup and view all the answers

In the early 1990s, some government-sanctioned research with psychedelics resumed.

<p>True</p> Signup and view all the answers

In the 1990s, the focus of psychedelic research switched from studying their phenomenological effects (the subjective experiences they produce) to understanding their physiological and neurological effects, and potential therapeutic uses.

<p>True</p> Signup and view all the answers

Psychedelics were being considered as potential treatments for severe substance abuse, pain, and depression associated with terminal illnesses.

<p>True</p> Signup and view all the answers

In 2006 three events occurred that shifted attitudes towards the potential benefits of psychedelics. The first event was the celebration of Albert Hofmann's 100th birthday, with a symposium that drew 200 journalists and over 1000 participants.

<p>True</p> Signup and view all the answers

The second event was the U.S. Supreme Court's decision to allow the religious sect Uniao do Vegetal to import the psychedelic brew ayahuasca into the United States.

<p>True</p> Signup and view all the answers

The third event was the publication of a paper reporting the results of an experiment at John Hopkins University in Baltimore, in which volunteers were given psilocybin, the psychedelic mushroom.

<p>True</p> Signup and view all the answers

There are more clinical trials in psychedelics happening today than ever before.

<p>True</p> Signup and view all the answers

What is the smallest dose of LSD that can produce some mild euphoria?

<p>10 micrograms</p> Signup and view all the answers

What is the typical dose of LSD?

<p>50 to 150 micrograms</p> Signup and view all the answers

How long does it take for LSD to take effect?

<p>45 to 60 minutes</p> Signup and view all the answers

The psychoactive effects of LSD can be noticeable in a matter of minutes. Effects can be increased heart rate, blood pressure, body temperature, dilated pupils, and mild dizziness.

<p>True</p> Signup and view all the answers

The psychoactive effects of drugs depend on the set and setting.

<p>True</p> Signup and view all the answers

What does "set" refer to?

<p>The expectations that a person has at the time of taking the drug</p> Signup and view all the answers

LSD can produce dramatic mood swings.

<p>True</p> Signup and view all the answers

What drug did the anthropologist Bhirendra experience while working with the Tamang shaman?

<p>LSD</p> Signup and view all the answers

What is the scientific name for the mushroom that McKenna ate?

<p>Stropharia cubensis</p> Signup and view all the answers

Psilocybin gets converted to psilocin when ingested.

<p>True</p> Signup and view all the answers

How long does a psilocybin trip typically last?

<p>Two to five hours</p> Signup and view all the answers

The physiological effects of psilocybin are like those of LSD but milder, and the psychological effects are more visual, less intense, and less dysphoric, compared to LSD.

<p>True</p> Signup and view all the answers

What is the name of the cactus that contains mescaline?

<p>Peyote cactus</p> Signup and view all the answers

How is peyote typically ingested?

<p>The tops are cut and dried to make buttons that are eaten</p> Signup and view all the answers

How much mescaline is considered an effective dose?

<p>200 milligrams</p> Signup and view all the answers

The effects of mescaline last from eight to twelve hours.

<p>True</p> Signup and view all the answers

Mescaline produces a more intense physiological arousal and a more sensual, perceptual, and stable trip than LSD.

<p>True</p> Signup and view all the answers

Huston Smith's experience with mescaline showed him that the drug "acted as a psychological prism", revealing multiple layers of the mind that he could move between at will.

<p>True</p> Signup and view all the answers

DMT has been found throughout the living natural world, including the human body and brain and has been synthesized.

<p>True</p> Signup and view all the answers

What happens when 50 milligrams or more of DMT are smoked or injected?

<p>Effects similar to those of LSD, except that greeting intensity is more intense, begin within a half-hour.</p> Signup and view all the answers

Who conducted research on the effects of DMT at the University of New Mexico?

<p>Rick Strassman</p> Signup and view all the answers

One of the striking results of Strassman's research was that at a sufficiently high dose, individuals reported being propelled to a world that exists independently of the individual mind.

<p>True</p> Signup and view all the answers

Strassman's research also found that contact with aliens, implantation of devices, and transmission of information can occur while under the influence of DMT.

<p>True</p> Signup and view all the answers

Strassman's research suggests that the pineal gland, a tiny gland in the middle of the brain that produces melatonin, could be the source of DMT surges.

<p>True</p> Signup and view all the answers

Strassman's research suggests that the production of DMT in the pineal gland is high enough to create otherworldly experiences.

<p>False</p> Signup and view all the answers

Where is ayahuasca found?

<p>The upper Amazon in South America</p> Signup and view all the answers

What is the name of the plant vine used to make ayahuasca?

<p>Banisteriopsis caapi</p> Signup and view all the answers

Ayahuasca can contain other plants in addition to Banisteriopsis caapi.

<p>True</p> Signup and view all the answers

The addition of Psychotria viridis adds DMT to ayahuasca.

<p>True</p> Signup and view all the answers

The addition of DMT to ayahuasca makes for better and brighter visions.

<p>True</p> Signup and view all the answers

Ayahuasca is known as a purgative because it causes vomiting and severe diarrhea.

<p>True</p> Signup and view all the answers

Ayahuasca can produce flying images of colored lights, geometric patterns, and animals such as jaguars, birds, and reptiles, as well as visions of spirit helpers, demons, deities, and distant events.

<p>True</p> Signup and view all the answers

Ayahuasca tourism began in the 1990s.

<p>True</p> Signup and view all the answers

Ayahuasca has been touted as a panacea, but it's important to be cautious about claims of its healing powers.

<p>True</p> Signup and view all the answers

Tolerance to LSD develops within two to three days and then disappears just as quickly.

<p>True</p> Signup and view all the answers

There is a cross-tolerance between many psychedelic drugs, meaning that intoxication with one of them will inhibit the effectiveness of another if it is taken shortly after the first.

<p>True</p> Signup and view all the answers

Researchers believe that psychedelic drugs work by increasing activity in the brain's serotonic neural pathways.

<p>True</p> Signup and view all the answers

Psychedelic drugs stimulate the 5-HT2 subtype of serotonergic receptors, which can increase activity in those pathways.

<p>True</p> Signup and view all the answers

Psychedelic drugs can both excite and inhibit by attaching to different receptors on the same neuron.

<p>True</p> Signup and view all the answers

The activity of the MDN is attenuated when under the influence of psychedelics, which could account for transformations of self-identity, including death and rebirth experiences.

<p>True</p> Signup and view all the answers

Psychedelic drugs may shift people's perception and conceptualization of the self and the world, leading to experiences that are more or less meaningful than their previous ones.

<p>True</p> Signup and view all the answers

There can be an increase in hypnagogic imagery and dreams may take on the vividness, intensity, and perceptual peculiarities of drug trips when under the influence of psychedelics.

<p>True</p> Signup and view all the answers

What is the most common adverse effect of psychedelic drugs?

<p>Flashbacks</p> Signup and view all the answers

Flashbacks can be triggered by intoxication with marijuana or selective serotonin reuptake inhibitors.

<p>True</p> Signup and view all the answers

There is a psychopharmacological resemblance between psychedelics and SSRIs, with not only reports of SSRIs triggering flashbacks but also an apparent heightening of SSRI activity by psychedelics.

<p>True</p> Signup and view all the answers

The perceptual aspects of flashbacks have been subsumed in a broad category of post-psychedelic perceptual disturbances called hallucinogen persisting perception disorder.

<p>True</p> Signup and view all the answers

These long-term alterations of perception can last from seconds to years.

<p>True</p> Signup and view all the answers

Some of these perceptual distortions include intensification of color, changes in size, images of geometric forms, images in the peripheral visual fields, afterimages, and stationary images of moving objects.

<p>True</p> Signup and view all the answers

The brain functions in a manner that maintains synaptic homeostasis.

<p>True</p> Signup and view all the answers

Flooding receptor sites with chemical agents that can activate them leads to a compensatory attenuated response.

<p>True</p> Signup and view all the answers

Research has shown that repeated administration of LSD to rats decreases the availability of the 5-HT2 receptor subtype in the brain.

<p>True</p> Signup and view all the answers

Chronic administration of LSD to rats for seven days resulted in alterations in the behaviors of rats that were detectable more than thirty days after the drug treatment.

<p>True</p> Signup and view all the answers

The effects of psychedelics on serotonin receptor binding have been noted in those with schizophrenia, and some medications used in the treatment of schizophrenia block 5-HT2 receptors.

<p>True</p> Signup and view all the answers

Some psychedelics can elicit schizophrenia-like symptoms in humans.

<p>True</p> Signup and view all the answers

Researchers have hypothesized that excessive 5-HT2 receptor activation may be a critical factor in psychotic schizophrenia, at least in some cases.

<p>True</p> Signup and view all the answers

Psychedelics may be able to precipitate schizophrenia.

<p>True</p> Signup and view all the answers

Psychedelic mood swings, visual hallucinations, mania, grandiosity, and religiosity can persist after a trip.

<p>True</p> Signup and view all the answers

The incidence figures for psychosis following the use of psychedelics have ranged from 0.008 to 4.6 percent.

<p>True</p> Signup and view all the answers

Research has found that 37 to 49 percent of those hospitalized for LSD psychosis had received previous psychiatric treatment.

<p>True</p> Signup and view all the answers

A comparison of people with schizophrenia with and without previous drug use and a control group of people without schizophrenia found that those using drugs had better psychological adjustment before the onset of schizophrenia than those not using drugs, but worse psychological adjustment than the non-schizophrenic individuals.

<p>True</p> Signup and view all the answers

In the schizophrenia study, the use of multiple drugs was common, making it difficult to implicate any single drug as a causative agent for chronic psychosis.

<p>True</p> Signup and view all the answers

Psychotomimetic effects of different drugs of abuse can be addictive, and these effects can contribute to chronic psychosis.

<p>True</p> Signup and view all the answers

There are differences between acute psychoses that develop two to seven days after using LSD and psychoses in which no drugs had been used, suggesting that some people are more vulnerable to psychosis induced by psychedelics.

<p>True</p> Signup and view all the answers

Hoffer and Osmond noted similarities between delirium tremens, the hallucinations reported by people in the throes of alcoholism, and psychotomimetic experiences under the influence of LSD.

<p>True</p> Signup and view all the answers

Hoffer and Osmond speculated that giving alcoholics a high dose of LSD would mimic delirium tremens before they sink to that stage. When they tried this, the results were apparently good.

<p>True</p> Signup and view all the answers

Hoffer and Osmond came to reconceptualize the LSD experiences as instances of mystical transcendence rather than psychosis.

<p>True</p> Signup and view all the answers

Arnold Ludwig and his colleagues randomly assigned 176 alcoholic hospital inpatients to four groups of 44. The groups were given either milieu therapy, LSD, psychotherapy, or hypnosis, or combination of these.

<p>True</p> Signup and view all the answers

Ludwig studied the effects of LSD therapy on alcoholics, and the study found no evidence that any of the LSD sessions made a difference in therapeutic outcomes.

<p>True</p> Signup and view all the answers

In conclusion, there were either no differences in outcomes with the use of LSD or the differences disappeared by the time of 6-month follow-ups. Given the serious social burden posed by alcoholism, the fact that individuals seeking conventional forms of treatment for alcoholism have a high failure rate, psychedelic treatment is being reexamined to see if there are ways of harnessing it.

<p>True</p> Signup and view all the answers

Stanislav Grof has conducted extensive research concerning the administration of psychedelic drugs to those who are dying of cancer.

<p>True</p> Signup and view all the answers

The purpose of psychedelic therapy for those who are dying is not treatment of their disease, but to relieve suffering and enhance spiritual experiences.

<p>True</p> Signup and view all the answers

The analgesic effects of psychedelics have sometimes persisted for weeks after their acute effects have worn off.

<p>True</p> Signup and view all the answers

Psychedelics have also changed people's attitudes towards death.

<p>True</p> Signup and view all the answers

Study Notes

Drug Dangerousness

  • Opium is a chemical extracted from opium poppy plants
  • Opioids contain opium or similar chemicals
  • Synthetic opioids are chemically similar to naturally occurring opioids
  • Fentanyl is a synthetic opioid used as an analgesic and anesthetic.
  • Heroin is often cut with fentanyl, leading to overdoses
  • Carfentanil is a highly potent opioid that has appeared in the illicit drug market
  • Opioids contribute to 25% of overdose deaths
  • Drug dangerousness is evaluated based on acute reactions, dependence, and healthcare impacts
  • Psychedelic drugs are not considered more dangerous than some other legal and illegal drugs

Modern History of Psychedelics

  • Humphry Osmond coined the term "psychedelic" in 1956.
  • Osmond was the director of Weyburn Mental Hospital in Canada
  • Abram Hoffer was Osmond's research director.
  • Osmond's hospital became a centre for psychedelic research.

The Invention of LSD

  • Albert Hofmann created LSD-25 in 1938
  • Hofmann was working at Sandoz company in Basel, Switzerland.
  • Hofmann experienced LSD-25 in 1943.
  • Hofmann's experience included intense visuals

Psychedelic Sixties

  • Timothy Leary was a prominent figure in the 1960s psychedelic movement.
  • Leary advocated the use of psychedelic drugs.
  • Leary believed that psychedelics can lead to spiritual awakening.
  • The term "turn on" referred to engaging with internal revelations.

Renaissance

  • Psychedelic research was revisited in the 1990s.
  • Research focused on the psychological and neurological effects of psychedelics.
  • Applications in treatment examined, specifically for substance abuse, pain, and depression

Varieties of Psychedelics

  • LSD is a potent drug with effects beginning at 50-100 micrograms
  • Typical doses range from 50 to 150 micrograms
  • Effects appear within 45-60 minutes, after ingestion.
  • Psilocybin is also a psychoactive compound found in some mushrooms.
  • Mescaline is extracted from the Peyote cactus.
  • DMT is a compound that occurs naturally.
  • Ayahuasca is a South American psychedelic cocktail.

Neuropharmacology of Psychedelics

  • Tolerance to LSD develops rapidly and then disappears.
  • Cross-tolerance exists between several psychedelic drugs.
  • Psychedelic effects are mediated by serotonergic neural pathways.
  • 5-HT2 subtype of serotonin receptors is a key target.

Long-term Effects of Psychedelics

  • Flashbacks are a transitory recurrence of emotions or perceptions from a psychedelic experience.
  • Psychedelic use may be linked to post-psychedelic perceptual disturbances.
  • Psychedelics may induce psychotic effects resembling schizophrenia, though not conclusive research.

Psychedelic Treatment of Alcoholism

  • Hoffer and Osmond explored the potential therapeutic applications of LSD treatment for alcoholism.
  • These studies saw LSD administered to patients to mimic the symptoms of delirium tremens.
  • Some studies show that the use of LSD during treatment improved patients but wasn't conclusive.

The Good Friday Experiment

  • Walter Pahnke conducted research on psychedelic experiences in a religious setting.
  • Subjects were given psilocybin before Good Friday services.
  • Pahnke observed experiences similar to those reported by mystics.
  • 61% of the subjects had a mystical experience.

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