Questions and Answers
Which of the following statements are true about opioid antagonists? (Select all that apply)
Which of the following would a nurse be most likely ordered to give to a client experiencing opioid-induced respiratory depression? (Select all that apply)
Which mechanism do opioid antagonists use to reverse the effects of opioid agonists? (Select all that apply)
When administering an opioid antagonist, what opioid effects would the nurse expect to reverse? (Select all that apply)
Signup and view all the answers
In which situation would an opioid antagonist most likely be needed? (Select all that apply)
Signup and view all the answers
What adverse reactions should a nurse monitor for when a client is receiving naloxone (Narcan)? (Select all that apply)
Signup and view all the answers
To which client should a nurse administer naloxone cautiously? (Select all that apply)
Signup and view all the answers
What medications should a nurse be careful when administering opioid antagonists to clients taking? (Select all that apply)
Signup and view all the answers
Study Notes
Opioid Antagonists Overview
- Opioid antagonists bind to opioid receptors with a greater affinity than opioid agonists, blocking receptor activation.
- They prevent responses to opioid agonists by binding to the receptors rather than the agonists themselves.
Indications for Use
- Naloxone is a primary opioid antagonist used for reversing opioid-induced respiratory depression.
- Naltrexone is another antagonist but mainly used for alcohol dependence rather than immediate respiratory issues.
Mechanism of Action
- Opioid antagonists reverse opioid agonist effects primarily through competitive inhibition and displacement from opioid receptors.
- Their action is not irreversible, and they do not mutate opioid receptors.
Reversal of Opioid Effects
- Opioid antagonists can reverse all adverse reactions caused by opioids, including respiratory depression, constipation, analgesia, hypotension, and bradycardia.
Situations Requiring Antagonist Administration
- Indications include postoperative respiratory depression, reversal of opioid-induced hypotension, and suspected acute opioid overdose.
- They are not typically used for reversing toxicity from non-opioid substances like phenytoin or benzodiazepines.
Adverse Reactions to Monitor
- Common reactions from naloxone include nausea, tachycardia, increased blood pressure, and tremors.
- Monitoring is essential for potential adverse reactions when administering opioid antagonists.
Caution in Administration
- Naloxone should be administered cautiously to pregnant clients, those with cardiovascular conditions, or individuals with opioid dependency.
- Clients on codeine, oxycodone, or diphenoxylate require careful monitoring as opioid antagonists may negate the therapeutic effects of these medications.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Explore the mechanisms, indications, and actions of opioid antagonists like Naloxone and Naltrexone. This quiz covers how these antagonists work, their competitive inhibition of opioid receptors, and their role in reversing opioid effects. Test your understanding of their clinical applications and significance in opioid-related emergencies.
