Oogenesis begins before birth in genetic females.
Oogonia differentiate into primary oocytes.
Oogonia increase rapidly in number, reaching 7 million by the fifth month of prenatal development.
Cell death begins, and many oogonia and primary oocytes become atretic.
Surviving primary oocytes enter prophase of meiosis I and are surrounded by flat epithelial cells, forming primordial follicles.
Primary oocytes remain in prophase and do not finish their first meiotic division before puberty due to oocyte maturation inhibitor.
The total number of primary oocytes at birth is estimated to vary from 700,000 to 2 million.
Only approximately 400,000 oocytes are present by the beginning of puberty.
Maturation of oocytes continues at puberty.
Primary oocytes enter the diplotene stage before proceeding into metaphase.

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