Questions and Answers
What type of medication is Omega-3 Acid Ethyl Esters (Lovaza)?
What is the FDA indication for Omega-3 Acid Ethyl Esters (Lovaza)?
As an adjunct to diet to reduce triglyceride levels in adult patients with very high triglyceride levels.
What should be monitored while taking Omega-3 Acid Ethyl Esters (Lovaza)?
Lipid panel
What are some potential mechanisms of action of Omega-3-fish oils?
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What are contraindications for Omega-3 Acid Ethyl Esters (Lovaza)?
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Which of the following is NOT an adverse effect of Omega-3 Acid Ethyl Esters (Lovaza)?
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What should patients do during consultation regarding Omega-3 Acid Ethyl Esters (Lovaza)?
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Study Notes
Omega-3 Acid Ethyl Esters (Lovaza) Overview
- Classified as an antihyperlipidemic medication.
FDA Indication
- Indicated as an adjunct to diet for lowering triglyceride (TG) levels in adults with very high triglyceride levels (≥500mg/dL).
- Patients must adhere to a lipid-lowering diet throughout treatment.
Monitoring
- Regular lipid panel assessments are essential to evaluate effectiveness and safety.
Pharmacology/Pharmacokinetics
- Mechanism of action is not fully understood; potential actions include:
- Inhibition of acyl CoA: 1,2 diacylglycerol acyltransferase.
- Enhanced mitochondrial and peroxisomal beta-oxidation in the liver.
- Decreased lipogenesis in the liver.
- Increased activity of plasma lipoprotein lipase.
Contraindications and Precautions
- Contraindicated for patients hypersensitive to any components of the medication.
- Cautious use is advised for individuals with fish allergies.
- Prior lifestyle changes such as reducing alcohol intake and weight loss should be attempted before starting treatment.
- Discontinuation may be necessary if plasma triglyceride levels rise due to estrogen therapy, thiazide diuretics, or beta blockers.
Adverse Effects
- Common side effects include:
- Belching, dyspepsia, taste preversion, and flu-like symptoms.
- Miscellaneous infections, back pain, rash, and angina.
Patient Consultation
- Recommended to take Lovaza with meals.
- Importance of adherence to prescribed dietary guidelines.
- Patients should contact their physician if severe or persistent side effects occur.
- Medication should be stored in a cool, dry place away from sunlight and children.
- If a dose is missed, it should be skipped and the normal dosing schedule should be resumed.
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Description
This quiz provides a comprehensive overview of Omega-3 Acid Ethyl Esters, also known as Lovaza. It covers FDA indications, monitoring practices, pharmacology, and contraindications. Essential for understanding its use in managing high triglyceride levels.
