Omega-3 Acid Ethyl Esters Overview

Study Notes

Omega-3 Acid Ethyl Esters (Lovaza) Overview

Classified as an antihyperlipidemic medication.

FDA Indication

Indicated as an adjunct to diet for lowering triglyceride (TG) levels in adults with very high triglyceride levels (≥500mg/dL).
Patients must adhere to a lipid-lowering diet throughout treatment.

Monitoring

Regular lipid panel assessments are essential to evaluate effectiveness and safety.

Pharmacology/Pharmacokinetics

Mechanism of action is not fully understood; potential actions include:
- Inhibition of acyl CoA: 1,2 diacylglycerol acyltransferase.
- Enhanced mitochondrial and peroxisomal beta-oxidation in the liver.
- Decreased lipogenesis in the liver.
- Increased activity of plasma lipoprotein lipase.

Contraindications and Precautions

Contraindicated for patients hypersensitive to any components of the medication.
Cautious use is advised for individuals with fish allergies.
Prior lifestyle changes such as reducing alcohol intake and weight loss should be attempted before starting treatment.
Discontinuation may be necessary if plasma triglyceride levels rise due to estrogen therapy, thiazide diuretics, or beta blockers.

Adverse Effects

Common side effects include:
- Belching, dyspepsia, taste preversion, and flu-like symptoms.
- Miscellaneous infections, back pain, rash, and angina.

Patient Consultation

Recommended to take Lovaza with meals.
Importance of adherence to prescribed dietary guidelines.
Patients should contact their physician if severe or persistent side effects occur.
Medication should be stored in a cool, dry place away from sunlight and children.
If a dose is missed, it should be skipped and the normal dosing schedule should be resumed.

Description

This quiz provides a comprehensive overview of Omega-3 Acid Ethyl Esters, also known as Lovaza. It covers FDA indications, monitoring practices, pharmacology, and contraindications. Essential for understanding its use in managing high triglyceride levels.