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What is the primary use of increased cholesterol supply during pregnancy?
What is the primary use of increased cholesterol supply during pregnancy?
What occurs in the second half of pregnancy regarding fat metabolism?
What occurs in the second half of pregnancy regarding fat metabolism?
Why are low-salt diets not recommended during pregnancy?
Why are low-salt diets not recommended during pregnancy?
Which of the following is NOT a function of the placenta?
Which of the following is NOT a function of the placenta?
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What is the significance of increased blood lipid levels during pregnancy?
What is the significance of increased blood lipid levels during pregnancy?
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Maternal calcium absorption increases during pregnancy primarily to:
Maternal calcium absorption increases during pregnancy primarily to:
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Which harmful substances can the placenta act as a barrier to?
Which harmful substances can the placenta act as a barrier to?
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What is the effect of a cholesterol-lowering diet during pregnancy on maternal cholesterol levels?
What is the effect of a cholesterol-lowering diet during pregnancy on maternal cholesterol levels?
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What is the primary factor influencing nutrient transfer across the placenta?
What is the primary factor influencing nutrient transfer across the placenta?
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Which nutrient transfer mechanism requires energy?
Which nutrient transfer mechanism requires energy?
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What percentage of glucose delivered by maternal circulation does the placenta use?
What percentage of glucose delivered by maternal circulation does the placenta use?
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Which of the following substances is most likely to be transferred across the placenta?
Which of the following substances is most likely to be transferred across the placenta?
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What happens when maternal nutrient intakes fall below optimum levels?
What happens when maternal nutrient intakes fall below optimum levels?
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Which type of molecules are least likely to be transferred across the placenta?
Which type of molecules are least likely to be transferred across the placenta?
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Which is NOT a mechanism of nutrient transport across the placenta?
Which is NOT a mechanism of nutrient transport across the placenta?
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What role does the placenta primarily play in nutrient transfer?
What role does the placenta primarily play in nutrient transfer?
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What physiological changes occur during the anabolic phase of pregnancy?
What physiological changes occur during the anabolic phase of pregnancy?
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Which pregnancy duration is classified as 'preterm'?
Which pregnancy duration is classified as 'preterm'?
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What relationship is observed between maternal nutrition and long-term health outcomes in offspring?
What relationship is observed between maternal nutrition and long-term health outcomes in offspring?
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What is the preferred fuel source for the fetus during pregnancy?
What is the preferred fuel source for the fetus during pregnancy?
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Which factor increases maternal reliance on fat for energy in late pregnancy?
Which factor increases maternal reliance on fat for energy in late pregnancy?
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What key nutrient is primarily accumulated during pregnancy for tissue synthesis?
What key nutrient is primarily accumulated during pregnancy for tissue synthesis?
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What is the definition of maternal mortality?
What is the definition of maternal mortality?
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How is edema characterized during pregnancy?
How is edema characterized during pregnancy?
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What role does progesterone play during pregnancy?
What role does progesterone play during pregnancy?
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Which of the following is a cause of infant mortality?
Which of the following is a cause of infant mortality?
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During which phase of pregnancy does increased lipolysis occur?
During which phase of pregnancy does increased lipolysis occur?
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What percentage of fetal growth occurs in the second half of pregnancy?
What percentage of fetal growth occurs in the second half of pregnancy?
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What is the consequence of prolonged fetal utilization of ketones?
What is the consequence of prolonged fetal utilization of ketones?
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What change in blood volume is typical during pregnancy?
What change in blood volume is typical during pregnancy?
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Study Notes
Nutrition During Pregnancy
- General Outcome: Become familiar with physiological changes in pregnancy and how these changes influence nutritional needs.
-
Specific Outcomes:
- Describe physiological changes during pregnancy.
- Identify recommended weight gain ranges for various pre-pregnancy weight categories (underweight, normal, overweight, obese).
- Identify relationships between nutritional status during pregnancy and long-term health outcomes in offspring.
Time-Related Terms
- Periconceptional: Period before conception, approximately 14 days before the next menstrual period.
- Trimester 1: Weeks 0-12.
- Trimester 2: Weeks 13-28.
- Trimester 3: Weeks 29-40.
- Preterm: Babies born before 37 weeks.
- Term: Babies born between 38 and 42 weeks.
- Postterm: Pregnancy lasting more than 42 weeks.
- Infancy: Period after birth.
- LMP: Last menstrual period (used to estimate gestational age).
- Perinatal: Definition varies from 20 to 24 weeks gestation to 7 to 28 days after birth.
- Fetal death/Stillbirth: Fetus dies after week 20 of pregnancy.
- Perinatal mortality: Fetus dies between 20 weeks of gestation or death of an infant who is less than a month old.
- Neonatal mortality: Death from delivery to 28 days.
- Post-neonatal mortality: Death from 28 days after birth to 1 year.
- Infant mortality: Death from birth to age 1 year.
Infant Mortality
- Indicator of a country's health level.
- Number of deaths of infants under one year per 1,000 live births.
- Decrease in mortality suggests improvements in social circumstances, safe nutrition, and infectious disease control.
Child Mortality in Malaysia
- Infant mortality rate declined from 41 to 6.9 deaths per 1,000 live births in Malaysia between 1970 and 2017.
- Malaysia has experienced significant improvements in health.
Causes of Infant Mortality
- Conditions originating in the perinatal period.
- Meningitis.
- Pneumonia.
- Chronic lower respiratory disease.
- Congenital malformations, deformations, and chromosomal abnormalities.
Maternal Mortality
- Deaths due to pregnancy and childbirth complications.
- Global maternal mortality ratio declined from 2000 to 2020 by 34%.
- 95% of maternal deaths occur in low and lower middle income countries.
- More than 80% of pregnancy related deaths are preventable.
Causes of Maternal Mortality
- Severe bleeding (mostly after childbirth).
- Infections (usually after childbirth).
- High blood pressure (pre-eclampsia).
- Complications from delivery.
- Unsafe abortion.
Maternal Mortality Ratio in Malaysia
- 1970: 141 deaths per 100,000 live births.
- 2019: 21 deaths per 100,000 live births.
Physiology of Pregnancy
- Pregnancy starts at conception approximately 14 days before the next menstrual period.
- Pregnancy averages 38 weeks (266 days), but 40 weeks (280 days) is common to relate to LMP.
- Gestational age: Duration from conception.
- Menstrual age: Estimated from the LMP.
Normal Physiology Changes During Pregnancy
- Anabolic phase (first half): Increased food intake, lipid absorption, and accumulation; increased estrogen and progesterone levels.
- Catabolic phase (second half): Increased lipolytic activity, decreased lipoprotein lipase activity, decreased insulin sensitivity, increased maternal lipid levels.
Maternal Anabolic Phase
- Blood volume & cardiac output increases.
- Fat, nutrients, and liver glycogen stores are built up.
- Maternal organs grow.
- Appetite & food intake increases.
- Exercise tolerance decreases.
Maternal Catabolic Phase
- Mobilization of fat & nutrient stores.
- Blood glucose, triglycerides, and fatty acids increase.
- Fasting metabolism accelerates.
- Catabolic hormones increase.
Fetal Growth
- Approximately 10% of fetal growth occurs in the first half of pregnancy, with the remaining 90% in the second half.
Body Water Changes
- Increased blood volume, extracellular fluid, and amniotic fluid are associated with pregnancy.
- High fluid gains are associated with edema and weight gain.
Hormonal Changes
- Placenta produces hormones (hCG, hCS, Estrogen, Leptin, Progesterone).
Hormones in more detail
- hCG: Stimulates estrogen and progesterone production, and endometrial growth.
- hCS: Increases insulin resistance, promotes maternal protein synthesis, and mobilizes fat.
- Estrogen: Increases lipid formation and storage, promotes uterine and breast development, improves ligament flexibility.
- Leptin: Regulates appetite, lipid metabolism, and weight gain.
- Progesterone: Maintains the implantation, relaxes uterine muscles, and stimulates breast development.
Carbohydrate Metabolism
- Glucose is the fetus' preferred fuel.
- Early pregnancy: Increased insulin production, conversion of glucose to glycogen and fat.
- Late pregnancy: Increased hCS and prolactin inhibit the conversion of glucose to glycogen, and insulin resistance increases in the mother, relying more on fats for energy.
Accelerated Fasting Metabolism
- Increased utilization of glucogenic amino acids for fat oxidation.
- Increased production of ketones to support fetal use in the absence of glucose.
- Prolonged use of ketones may lead to impaired fetal development.
Protein Metabolism
- Protein is needed for maternal and fetal tissue synthesis.
- About 925 grams of protein are accumulated during pregnancy.
- Maternal protein intake supports fetal and maternal needs.
- Protein needs are met through reduced nitrogen excretion and amino acid conservation.
Fat Metabolism
- Maternal fat accumulation in the first half of pregnancy.
- Increased fat mobilization in the second half of pregnancy for fetal needs.
- Blood lipid levels rise dramatically during pregnancy.
Placenta
- Derived from the Latin word for "cake".
- Round and disk-like shape.
Placenta Functions
- Hormone and enzyme production.
- Nutrient and gas exchange between mother and fetus.
- Waste product removal from the fetus.
- Acts as a barrier to harmful compounds.
Nutrient Transfer in Placenta
- The placenta uses 30-40% of the glucose from maternal circulation.
- Fetus also receives small amounts of water and other nutrients from amniotic fluid.
- Factors influencing nutrient transfer include molecule size, solubility, and concentration gradients. Smaller, more lipid-soluble molecules transfer more easily than larger ones.
Mechanisms of Nutrient Transport
- Passive diffusion: Nutrients move from high to low concentration.
- Facilitated diffusion: Receptors on cell membranes speed up nutrient transfer.
- Active transport: Energy (ATP) is used to move nutrients against a concentration gradient.
- Endocytosis: Large molecules are engulfed and transported into cells.
Fetus Not a Parasite
- The fetus depends on the mother for nutrients.
- Maternal nutrient intake affects fetal growth and development more than maternal health.
- Nutrients first support maternal needs then placental development.
Mineral Metabolism
- Maternal calcium absorption and mobilization from bones increase.
- Increased needs for sodium and other minerals.
- Restricted sodium intake can impact growth.
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Description
This quiz explores the key physiological changes during pregnancy and their impact on nutritional requirements. Participants will learn about recommended weight gain for various pre-pregnancy categories and the long-term health implications for offspring based on maternal nutrition. Test your knowledge about essential terms and guidelines related to pregnancy nutrition.