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Questions and Answers
What is the threshold for classifying an individual as obese based on BMI?
What is the threshold for classifying an individual as obese based on BMI?
- BMI > 30 (correct)
- BMI > 35
- BMI > 25
- BMI > 27
Which of the following is a serious disorder highly related to obesity?
Which of the following is a serious disorder highly related to obesity?
- Alzheimer's disease
- Asthma
- Diabetes mellitus (correct)
- Influenza
What demographic trend has been observed regarding obesity prevalence in lower socio-economic groups?
What demographic trend has been observed regarding obesity prevalence in lower socio-economic groups?
- Higher prevalence in lower socio-economic groups (correct)
- No significant change with economic status
- Lower incidence in lower socio-economic groups
- Higher prevalence in upper socio-economic groups
In which regions is the prevalence of obesity accelerating markedly?
In which regions is the prevalence of obesity accelerating markedly?
What is a limitation of using BMI as a metric for obesity?
What is a limitation of using BMI as a metric for obesity?
What serious condition is NOT listed as a consequence of obesity?
What serious condition is NOT listed as a consequence of obesity?
Which vitamin's supplementation successfully ended an epidemic of rickets?
Which vitamin's supplementation successfully ended an epidemic of rickets?
Which accessory organ is primarily responsible for the initial breakdown of starch?
Which accessory organ is primarily responsible for the initial breakdown of starch?
What is the primary function of the vagus nerve in relation to the gastrointestinal tract?
What is the primary function of the vagus nerve in relation to the gastrointestinal tract?
Which of the following nutrients is associated with the prevention of pernicious anemia?
Which of the following nutrients is associated with the prevention of pernicious anemia?
What condition resulted from thiamine deficiency, often linked to polished rice consumption?
What condition resulted from thiamine deficiency, often linked to polished rice consumption?
Which food-related disease is NOT mentioned as a consequence of obesity?
Which food-related disease is NOT mentioned as a consequence of obesity?
Which statement about sensory receptors in the GI tract is true?
Which statement about sensory receptors in the GI tract is true?
What is the primary effect of extendin-4 in animals?
What is the primary effect of extendin-4 in animals?
How does extendin-4 differ from GLP-1 in terms of stability?
How does extendin-4 differ from GLP-1 in terms of stability?
What is one clinical outcome improved by GLP-1 treatments?
What is one clinical outcome improved by GLP-1 treatments?
What happens when food enters the distal small intestine?
What happens when food enters the distal small intestine?
Which factor is known to worsen triglyceride levels in relation to dietary carbohydrates?
Which factor is known to worsen triglyceride levels in relation to dietary carbohydrates?
Which of the following factors makes individuals more sensitive to dietary carbohydrate effects?
Which of the following factors makes individuals more sensitive to dietary carbohydrate effects?
What is the significance of the Gila monster's saliva in medical research?
What is the significance of the Gila monster's saliva in medical research?
What is the 'intestinal brake' concept associated with GLP-1?
What is the 'intestinal brake' concept associated with GLP-1?
What type of protein deficiency is characterized solely by a lack of protein?
What type of protein deficiency is characterized solely by a lack of protein?
Which of the following best describes the Acceptable Macronutrient Distribution Range (AMDR) for protein in adults?
Which of the following best describes the Acceptable Macronutrient Distribution Range (AMDR) for protein in adults?
How much protein is generally recommended per kilogram of body weight for adults?
How much protein is generally recommended per kilogram of body weight for adults?
What is considered to be a high-quality protein according to the Digestible Indispensable Amino Acid Score (DIAAS)?
What is considered to be a high-quality protein according to the Digestible Indispensable Amino Acid Score (DIAAS)?
What happens to excess protein beyond the optimal synthesis threshold?
What happens to excess protein beyond the optimal synthesis threshold?
Which combination of foods can provide a complete protein in a vegan diet?
Which combination of foods can provide a complete protein in a vegan diet?
Which condition involves both energy and protein deficiency?
Which condition involves both energy and protein deficiency?
What effect does regular aerobic exercise have on protein requirements for athletes?
What effect does regular aerobic exercise have on protein requirements for athletes?
What does glycemic load measure?
What does glycemic load measure?
Which of the following food items has a very low glycemic index?
Which of the following food items has a very low glycemic index?
What is a primary cause of insulin resistance in skeletal muscle?
What is a primary cause of insulin resistance in skeletal muscle?
Which diabetes type is characterized by the absence of insulin production?
Which diabetes type is characterized by the absence of insulin production?
What effect does a hypocaloric diet have on the metabolic rate?
What effect does a hypocaloric diet have on the metabolic rate?
What is the metabolic fate of carbohydrates when consumed in excess?
What is the metabolic fate of carbohydrates when consumed in excess?
What is the primary source of dietary protein for about two-thirds of the population in the U.S.?
What is the primary source of dietary protein for about two-thirds of the population in the U.S.?
How do whole grains affect heart disease risk?
How do whole grains affect heart disease risk?
What is true about essential amino acids?
What is true about essential amino acids?
Which of the following is an example of insulin resistance affecting the liver?
Which of the following is an example of insulin resistance affecting the liver?
Which macronutrient has the greatest thermogenic effect based on the calorie composition?
Which macronutrient has the greatest thermogenic effect based on the calorie composition?
What leads to the poor glucose control indicated by high HbA1C levels?
What leads to the poor glucose control indicated by high HbA1C levels?
What is the effect of a high-carbohydrate, low-fat diet on weight loss?
What is the effect of a high-carbohydrate, low-fat diet on weight loss?
What is the main function of Cholecystokinin in digestion?
What is the main function of Cholecystokinin in digestion?
Which type of carbohydrate consists of only one sugar unit?
Which type of carbohydrate consists of only one sugar unit?
How does pepsinogen become an active digestive enzyme?
How does pepsinogen become an active digestive enzyme?
Which statement about fiber is correct?
Which statement about fiber is correct?
What effect does salivary amylase have on carbohydrates?
What effect does salivary amylase have on carbohydrates?
Which of the following is NOT a source of glucose?
Which of the following is NOT a source of glucose?
What type of carbohydrate is lactose?
What type of carbohydrate is lactose?
Which of the following hormones increases hunger when the body has not eaten?
Which of the following hormones increases hunger when the body has not eaten?
What is the primary role of pancreatic amylase in digestion?
What is the primary role of pancreatic amylase in digestion?
What indicates a food's glycemic index of 70?
What indicates a food's glycemic index of 70?
Which nutrient is absorbed most easily in the stomach?
Which nutrient is absorbed most easily in the stomach?
In the context of dietary carbohydrates, which statement is true?
In the context of dietary carbohydrates, which statement is true?
What is the primary ingredient that leads to lactose intolerance?
What is the primary ingredient that leads to lactose intolerance?
What process is responsible for linking two sugar molecules together?
What process is responsible for linking two sugar molecules together?
Flashcards
Obesity
Obesity
A condition where a person has significantly more body fat than lean tissue, leading to various health problems.
Body Mass Index (BMI)
Body Mass Index (BMI)
A weight-based measure used to assess obesity, calculated by dividing the body weight in kilograms by the square of the height in meters.
BMI Thresholds for Obesity
BMI Thresholds for Obesity
A BMI value greater than 30 indicates obesity, while a value between 27 and 30 suggests overweight.
Limitations of BMI
Limitations of BMI
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Obesity and Socioeconomic Status
Obesity and Socioeconomic Status
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What is the lumen of the digestive tract?
What is the lumen of the digestive tract?
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What are accessory organs in the digestive system?
What are accessory organs in the digestive system?
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What are the roles of salivary glands?
What are the roles of salivary glands?
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What is a key role of the GI tract beyond digestion?
What is a key role of the GI tract beyond digestion?
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How does the GI tract affect the body beyond digestion?
How does the GI tract affect the body beyond digestion?
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How is taste connected to the GI tract?
How is taste connected to the GI tract?
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What are the main digestive organs?
What are the main digestive organs?
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What are the main nerves controlling GI functions?
What are the main nerves controlling GI functions?
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Cholecystokinin (CCK)
Cholecystokinin (CCK)
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Incretins (GLP-1 & GIP)
Incretins (GLP-1 & GIP)
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Peptide YY (PYY)
Peptide YY (PYY)
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Neuropeptide Y (NPY)
Neuropeptide Y (NPY)
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Ghrelin
Ghrelin
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Substance P
Substance P
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Gastrointestinal Motility
Gastrointestinal Motility
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Peristalsis
Peristalsis
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Digestion
Digestion
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Pepsinogen
Pepsinogen
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Glucose
Glucose
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Gluconeogenesis
Gluconeogenesis
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Glycogen
Glycogen
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Starches
Starches
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Fiber
Fiber
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Carb Digestion
Carb Digestion
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What are enzymes?
What are enzymes?
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What do transport proteins do?
What do transport proteins do?
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What are antibodies?
What are antibodies?
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What are contractile proteins?
What are contractile proteins?
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What are hormones?
What are hormones?
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How do proteins regulate fluids and pH?
How do proteins regulate fluids and pH?
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What is the recommended daily protein intake?
What is the recommended daily protein intake?
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What is protein synthesis?
What is protein synthesis?
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Glycemic Load
Glycemic Load
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Carbohydrate Oxidation
Carbohydrate Oxidation
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Insulin Resistance
Insulin Resistance
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Glycosylation
Glycosylation
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Basal Metabolic Rate (BMR)
Basal Metabolic Rate (BMR)
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Non-Exercise Activity Thermogenesis (NEAT)
Non-Exercise Activity Thermogenesis (NEAT)
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Lipogenesis
Lipogenesis
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Protein Digestion
Protein Digestion
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Protein Turnover
Protein Turnover
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Essential Amino Acids
Essential Amino Acids
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Transamination
Transamination
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Protein Structure
Protein Structure
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Sickle Cell Anemia
Sickle Cell Anemia
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Protein Digestion
Protein Digestion
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Protein Turnover
Protein Turnover
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What is GLP-1?
What is GLP-1?
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What is Extendin-4?
What is Extendin-4?
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What is the "Intestinal Brake"?
What is the "Intestinal Brake"?
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How does GLP-1 affect weight?
How does GLP-1 affect weight?
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What are the clinical benefits of GLP-1?
What are the clinical benefits of GLP-1?
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What makes people more susceptible to the negative effects of carbohydrates?
What makes people more susceptible to the negative effects of carbohydrates?
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What factors amplify the negative effects of carbs?
What factors amplify the negative effects of carbs?
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What is the recommended approach to carbohydrate intake?
What is the recommended approach to carbohydrate intake?
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Study Notes
Obesity Statistics and Prevalence
- Obesity is increasing globally; in the US, it rose from 15% in 1976-80 to 33% in adults today.
- Youth are increasingly affected, making it a growing concern.
- Obesity is strongly linked to significant health problems such as cardiovascular disease, diabetes, liver disease, and other serious conditions, becoming a major cause of death.
Obesity as a Disorder
- Obesity is characterized by having excessive body fat relative to lean tissue.
- It is frequently diagnosed using Body Mass Index (BMI).
- BMI > 30 is categorized as obese, while BMI > 27 is considered overweight.
- Importantly, BMI is not a perfect measure; a more accurate assessment involves determining body fat stores, and criteria for classification vary by age, sex, and ethnicity.
Demographics and Prevalence
- Obesity prevalence is more pronounced among lower socio-economic groups in developed, western countries.
- This trend opposes historical patterns.
- Recent data indicates high prevalence in minority groups in the US, and increases are notable in several developing regions like Asia, South America, urban Africa, and central Europe.
- Historically, obesity was uncommon, but it is now a common occurrence.
Diseases Associated with Obesity
- Obesity is strongly linked to several diseases and conditions, including:
- Cancers (especially colon, prostate, and breast)
- Sleep and breathing disorders
- High blood pressure
- Gall bladder disease
- Dyslipidemia (lipid disorders)
- Reproductive dysfunction
- Cardiovascular disease, stroke
- Liver disease (NAFLD)
- Depression
- Cognitive impairment (e.g., Alzheimer's).
Nutritional Interventions in the Past
- Pellagra was dramatically reduced by niacin fortification in bread.
- Rickets incidence declined substantially due to vitamin D supplementation in milk and other foods.
- Iodine addition to salt helped control endemic goiter and cretinism.
- Beriberi was largely eliminated by thiamine supplementation, particularly for rice consumption.
- Vitamin C supplementation effectively prevented scurvy.
- Iron and folate supplementation reduced anemia, a major problem in women, especially pregnant women
- Pernicious anemia was cured via monthly vitamin B12 injections.
Gastric Phase
- Food entering the stomach—smell, taste, sight of food—stimulates gastric secretions as part of preparation, involving signals from the brain. This phase also controls the passage of food from the stomach to the intestines.
- Stomach acid, enzymes, such as HCI, pepsin, and gastric lipase, and hormones (e.g. gastrin) facilitate digestion.
- Intrinsic factor, needed for vitamin B12 absorption, is secreted.
Intestinal Phase
- Entry of food into the small intestine triggers hormonal responses in the small intestine, initiating a process to slow and regulate gastric secretion.
- Stomach motility is reduced to allow proper digestion by the intestines.
- Pancreatic and intestinal enzymes, such as bicarbonate, are secreted by the intestines to help further digest carbohydrates into sugars.
Digestion of Nutrients
- Other functions of the GI tract include: regulating nutrients and fluids, defending against infections, absorbing fluids and electrolytes, and producing important hormones and bioactive compounds.
Macronutrients Summary
- All foods need macronutrients: carbohydrates, proteins, fats, vitamins, and minerals.
- Carbohydrates are a primary energy source for the body and come in different forms (simple and complex).
- Simple carbohydrates are made of a single sugar molecule.
- Complex carbohydrates are made of multiple sugar units, found in many plant-based sources.
- Refined grains are commonly stripped of many of their nutrients during processing. Whole grains retain essential nutrients.
- Fats are essential; they provide energy and are crucial for hormone production and cell structure. A variety of fats is important.
- Protein functions include structure and enzyme production; it's a key component in many bodily functions.
Obesity Considerations in the context of Diet
- High-fructose corn syrup intake is correlated with increased obesity rates.
- Whole-grain foods provide a combination of carbohydrates, vitamins, minerals and fiber that are beneficial for health.
- People with varied diets and diverse needs require varying amounts of macronutrients like carbohydrates and proteins for optimal energy and nutrient intake.
- High carbohydrate diets can also lead to weight loss if coupled with decreased fat intake.
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