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Questions and Answers
A patient is being treated for a vaginal yeast infection. The nurse knows that which of the following medications is the drug of choice for this condition?
A patient is being treated for a vaginal yeast infection. The nurse knows that which of the following medications is the drug of choice for this condition?
A patient is prescribed ketoconazole for a fungal infection. The nurse should monitor the patient for which of the following potential adverse effects?
A patient is prescribed ketoconazole for a fungal infection. The nurse should monitor the patient for which of the following potential adverse effects?
A patient is being treated for a fungal infection. The nurse knows that which of the following medications is the only antifungal agent that can be used to treat intestinal candidiasis?
A patient is being treated for a fungal infection. The nurse knows that which of the following medications is the only antifungal agent that can be used to treat intestinal candidiasis?
A patient is being treated for a fungal infection with amphotericin B (Abelcet). The nurse should closely monitor the patient for which of the following potential adverse effects?
A patient is being treated for a fungal infection with amphotericin B (Abelcet). The nurse should closely monitor the patient for which of the following potential adverse effects?
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A patient is prescribed clotrimazole cream for a skin infection. The nurse should advise the patient to avoid which of the following activities while using this medication?
A patient is prescribed clotrimazole cream for a skin infection. The nurse should advise the patient to avoid which of the following activities while using this medication?
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What is the time frame for a delayed allergic reaction?
What is the time frame for a delayed allergic reaction?
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Which adverse effects are commonly associated with amoxicillin?
Which adverse effects are commonly associated with amoxicillin?
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What is the role of clavulanate when combined with amoxicillin?
What is the role of clavulanate when combined with amoxicillin?
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What should be considered when adjusting the dose of amoxicillin for a patient with renal impairment?
What should be considered when adjusting the dose of amoxicillin for a patient with renal impairment?
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Which antibiotic is specifically resistant to penicillinase?
Which antibiotic is specifically resistant to penicillinase?
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Which of the following uses are appropriate for tetracycline?
Which of the following uses are appropriate for tetracycline?
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What is a common side effect associated with macrolides like erythromycin?
What is a common side effect associated with macrolides like erythromycin?
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In which situation would clindamycin be preferred over penicillin?
In which situation would clindamycin be preferred over penicillin?
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Which of the following statements about linezolid (Zyvox) is true?
Which of the following statements about linezolid (Zyvox) is true?
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What should be avoided when taking tetracycline due to its absorption issues?
What should be avoided when taking tetracycline due to its absorption issues?
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Which antibiotic is known to cause Clostridium difficile-associated diarrhea (CDAD)?
Which antibiotic is known to cause Clostridium difficile-associated diarrhea (CDAD)?
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Which mechanism of action is shared by both tetracyclines and macrolides?
Which mechanism of action is shared by both tetracyclines and macrolides?
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What is a characteristic side effect of tetracyclines?
What is a characteristic side effect of tetracyclines?
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Which antibiotic is typically administered first for a patient with Enterococcus faecalis infection?
Which antibiotic is typically administered first for a patient with Enterococcus faecalis infection?
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What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
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What is a significant side effect associated with the use of ciprofloxacin?
What is a significant side effect associated with the use of ciprofloxacin?
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Which of the following is NOT a typical use for nitrofurantoin?
Which of the following is NOT a typical use for nitrofurantoin?
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Which of the following side effects is associated with nitrofurantoin?
Which of the following side effects is associated with nitrofurantoin?
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What is the recommended course of action regarding prophylactic antibiotics for a patient with recurrent urinary tract infections?
What is the recommended course of action regarding prophylactic antibiotics for a patient with recurrent urinary tract infections?
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Which of the following patients is at higher risk for tendon rupture when taking fluoroquinolones?
Which of the following patients is at higher risk for tendon rupture when taking fluoroquinolones?
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Which of the following antibiotics is NOT effective against Enterococcus faecalis?
Which of the following antibiotics is NOT effective against Enterococcus faecalis?
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Which symptom is commonly associated with a C.difficile infection in older adult patients?
Which symptom is commonly associated with a C.difficile infection in older adult patients?
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Which medication is the primary drug of choice for treating C.difficile infections?
Which medication is the primary drug of choice for treating C.difficile infections?
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What is a common adverse effect of amphotericin B?
What is a common adverse effect of amphotericin B?
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What should the nurse advise a pregnant adolescent patient regarding the prescription for tetracycline?
What should the nurse advise a pregnant adolescent patient regarding the prescription for tetracycline?
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Which food should be avoided when administering oral ciprofloxacin?
Which food should be avoided when administering oral ciprofloxacin?
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Which antibiotic is most likely to be administered to a 6-week-old infant with a severe cough awaiting culture results?
Which antibiotic is most likely to be administered to a 6-week-old infant with a severe cough awaiting culture results?
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What is the mechanism of action of itraconazole?
What is the mechanism of action of itraconazole?
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What major side effect is associated with ketoconazole?
What major side effect is associated with ketoconazole?
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What is a common adverse effect of aminoglycosides that must be monitored?
What is a common adverse effect of aminoglycosides that must be monitored?
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To minimize toxicity while treating with gentamicin, which lab value is essential for monitoring?
To minimize toxicity while treating with gentamicin, which lab value is essential for monitoring?
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Which of the following drugs can cause an elevation of theophylline levels?
Which of the following drugs can cause an elevation of theophylline levels?
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Which aminoglycoside is considered the drug of choice when gentamicin is resistant?
Which aminoglycoside is considered the drug of choice when gentamicin is resistant?
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What condition is fluconazole primarily used to treat?
What condition is fluconazole primarily used to treat?
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What is a key characteristic of aminoglycosides in relation to their pharmacokinetics?
What is a key characteristic of aminoglycosides in relation to their pharmacokinetics?
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Which statement correctly describes the route of administration for monitoring peak levels of aminoglycosides?
Which statement correctly describes the route of administration for monitoring peak levels of aminoglycosides?
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What type of bacteria are aminoglycosides primarily effective against?
What type of bacteria are aminoglycosides primarily effective against?
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Flashcards
Broad-spectrum antibiotic
Broad-spectrum antibiotic
A type of antibiotic that is effective against a wide range of bacteria, including gram-negative bacteria.
Narrow-spectrum antibiotic
Narrow-spectrum antibiotic
A type of antibiotic that is effective against a narrower range of bacteria, often targeting specific types.
Anaphylaxis
Anaphylaxis
A severe, life-threatening allergic reaction to a drug or substance, characterized by airway swelling, difficulty breathing, and a rapid drop in blood pressure.
Cephalosporins
Cephalosporins
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Penicillins
Penicillins
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Tetracycline
Tetracycline
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Tetracycline & GI irritation
Tetracycline & GI irritation
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Tetracycline & Calcium
Tetracycline & Calcium
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Macrolide (Erythromycin)
Macrolide (Erythromycin)
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Clindamycin (Cleocin)
Clindamycin (Cleocin)
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Clostridium difficile-associated diarrhea (CDAD)
Clostridium difficile-associated diarrhea (CDAD)
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Linezolid (Zyvox)
Linezolid (Zyvox)
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Linezolid & Digestive Issues
Linezolid & Digestive Issues
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Aminoglycosides
Aminoglycosides
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Nephrotoxicity
Nephrotoxicity
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Ototoxicity
Ototoxicity
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Ototoxicity and Aminoglycosides
Ototoxicity and Aminoglycosides
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Peak Level
Peak Level
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Trough Level
Trough Level
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Amikacin for Resistant Infections
Amikacin for Resistant Infections
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Gentamicin
Gentamicin
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Nitrofurantoin (Macrodantin)
Nitrofurantoin (Macrodantin)
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Fluoroquinolones
Fluoroquinolones
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Ciprofloxacin (Cipro)
Ciprofloxacin (Cipro)
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Tendon rupture
Tendon rupture
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Prophylactic antibiotics
Prophylactic antibiotics
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Lower urinary tract infection (UTI)
Lower urinary tract infection (UTI)
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Clotrimazole (Lotrimin)
Clotrimazole (Lotrimin)
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Amphotericin B (Abelcet)
Amphotericin B (Abelcet)
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Azoles (Fluconazole, Itraconazole, Ketoconazole)
Azoles (Fluconazole, Itraconazole, Ketoconazole)
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Nystatin (Mycostatin)
Nystatin (Mycostatin)
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Clostridium difficile (C.diff) infection
Clostridium difficile (C.diff) infection
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Antibiotic
Antibiotic
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C. difficile infection
C. difficile infection
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Antifungal
Antifungal
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Study Notes
Antibiotics & Anti-Infectives
- Antibiotics are medicines commonly used to treat infectious diseases
- Antimicrobial drugs kill or suppress microorganisms, both naturally produced and synthetically produced
- Selective Toxicity is the ability of a drug to injure a target cell or organism without harming other, nearby cells or organisms
- Some antibiotics disrupt bacterial cell walls or inhibit bacterial enzyme synthesis
- Common objectives for learning about antibiotics include: recognizing which antibiotics are best suited for treating common infections, applying knowledge of antibiotics to patient care, evaluating the effectiveness of antibiotic treatments, and prioritizing/titrating medicine dosage
Basic Principles of Antimicrobial Therapy
- Large numbers of antibiotics are used daily in hospitals (over 190 million doses)
- Antibiotics significantly reduced disease morbidity and mortality since the 1930s-1940s
- Antibiotics are chemical agents produced by one microbe and can harm other microbes
- Basic concepts of antibiotic use should be understood to avoid improper usage, which can lead to antibiotic resistance
Classification of Antimicrobial Drugs
- Cell wall synthesis inhibitors
- Cell membrane permeability inhibitors
- Protein synthesis inhibitors
- Nucleic acid synthesis inhibitors
- Antimetabolites
- Viral enzyme inhibitors
Acquired Resistance to Antimicrobial Drugs
- Microbes over time develop resistance to antibiotics (due to several mechanisms)
- Decreasing the concentration of an antibiotic at the target site
- Inactivating the antibiotic
- Changing the structure of a drug target molecule
- Producing a drug antagonist
Cell Envelope
- Gram-negative cell envelope: has three layers (thin cell wall and an outer membrane)
- Gram-positive cell envelope: has only two layers (and a relatively thick cell wall)
Penicillins
- Penicillin G a bactericidal that is highly active against gram-positive organisms, with a lower effect against gram-negative ones.
- Penicillin is one of the most common cause of drug allergies.
- Penicillinase-resistant penicillins are highly effective against penicillin-resistant strains.
Penicillin Combinations
- Some penicillins are combined with other drugs to widen the spectrum of organisms that the medication is effective against
- Some combinations include: Amoxicillin/clavulanate, Piperacillin/tazobactam
Penicillin Allergy
- Allergic reactions to penicillin can range from minor rashes to life-threatening anaphylaxis
- Between 0.4% and 7% of penicillin users experience allergic reactions
- Allergic reactions can be immediate (within 30 minutes) or delayed (days to weeks).
Mechanisms of Bacterial Resistance
- Microbes may alter the targets that antibiotics attack
- Bacteria may develop resistance to antibiotics due to inactivation of the drug by bacterial enzymes or inability to access the drug target site
- Bacterial resistance is driven by several factors.
Antibiotic Use and Drug-Resistant Microbe Emergence
- Prescribing antibiotics affects the antibiotic resistance of bacteria
- The amount of antibiotic use affects the development of antibiotic resistance
- Nosocomial infections
- Superinfection
- New infections
- Emergent infections
Delaying Emergence of Drug Resistance
- Reduce demand for antibiotics among those who are healthy
- Emphasize adherence to prescribed antibiotic regimens
Host Factors
- Immune responses of the host
- Factors related to infections sites
Patient Variables
- Patient allergies to medications
- Evaluating the effectiveness of drug treatments
- Managing adverse reactions
- Prioritizing and titrating medications based on assessments and doctor's orders, as well as verifying appropriateness and accuracy of orders for medications.
Infections
- Urinary tract infection
- Bacterial endocarditis
- Neutropenia
- Other conditions
Teaching Patients
- Do not prematurely stop taking antibiotics
- Contact the doctor for allergic reactions
- Do not share medications
Cephalosporins
- A common class of beta-lactam antibiotics
- Resistance to cephalosporins has been associated to the same factors as resistance for penicillin
- Divided into four generations depending on gram-positive and gram-negative coverage
Other Antibiotics
- Tetracyclines
- Macrolides
- Aminoglycosides
- Vancomycin
- Trimethoprim/sulfamethoxazole
Specific Antibiotic Uses, Examples, and Adverse Effects
- Detailed descriptions of specific antibiotics (with examples, uses, and potential side effects) are included; and further elaborated in the subtopics/sections. Information such as potential side effects, drug interactions, and doses are available.
Drug Therapy for UTIs
- TMP/SMZ and nitrofurantoin are common drugs used for UTIs
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Description
Test your knowledge on antifungal treatments and their potential adverse effects with this nursing quiz. The questions cover various medications used for fungal infections, including the drug of choice for vaginal yeast infections and monitoring procedures for others. Enhance your understanding of patient care in fungal infections.