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Questions and Answers
Which of the following best describes a nucleophilic substitution reaction?
Which of the following best describes a nucleophilic substitution reaction?
- A reaction in which an electron-deficient species replaces a functional group in an electron-rich molecule
- A reaction in which an electron-rich species replaces a functional group in an electron-deficient molecule (correct)
- A reaction in which two electron-rich species combine to form a new molecule
- A reaction in which two electron-deficient species combine to form a new molecule
What is the role of the nucleophile in a nucleophilic substitution reaction?
What is the role of the nucleophile in a nucleophilic substitution reaction?
- It is an electron-deficient molecule
- It attacks the substrate and bonds with it (correct)
- It departs with an electron pair
- It is a leaving group
What is the principal product of a nucleophilic substitution reaction?
What is the principal product of a nucleophilic substitution reaction?
- Nuc
- LG
- R-Nuc (correct)
- R-LG
Which of the following can be a nucleophile in a nucleophilic substitution reaction?
Which of the following can be a nucleophile in a nucleophilic substitution reaction?
What is the leaving group in a nucleophilic substitution reaction?
What is the leaving group in a nucleophilic substitution reaction?
Flashcards
Nucleophilic Substitution Reaction
Nucleophilic Substitution Reaction
A reaction where an electron-rich species replaces a functional group in an electron-deficient molecule.
Role of Nucleophile
Role of Nucleophile
The nucleophile attacks the substrate (electron-deficient molecule) and forms a bond with it.
Product of Nucleophilic Substitution
Product of Nucleophilic Substitution
The principal product is the original molecule (R) now bonded to the nucleophile (Nuc): R-Nuc
Leaving Group (LG)
Leaving Group (LG)
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Study Notes
Nucleophilic Substitution Reaction
- A nucleophilic substitution reaction is a type of organic reaction where a nucleophile replaces a leaving group in a substrate.
Nucleophile's Role
- The nucleophile plays a crucial role in a nucleophilic substitution reaction by donating an electron pair to form a new bond with the substrate.
Principal Product
- The principal product of a nucleophilic substitution reaction is a new compound with a new bond between the substrate and the nucleophile.
Nucleophile Examples
- Examples of nucleophiles in a nucleophilic substitution reaction include negatively charged species like Cl-, OH-, and CN-, as well as neutral species with a lone pair of electrons like NH3 and H2O.
Leaving Group
- The leaving group in a nucleophilic substitution reaction is a group that leaves the substrate, forming a new bond with the nucleophile, and is typically a stable molecule or ion with a weak bond to the substrate.
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