NSAIDs and Asthma Risk

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Which of the following is a potential risk associated with NSAID use in patients with asthma?

Exacerbation of asthma symptoms

What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?

Inhibition of prostaglandin synthesis but not leukotriene synthesis

Why should NSAIDs be used with caution in patients with asthma?

They inhibit prostaglandin synthesis, potentially increasing the risk of asthma exacerbations

Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?

Phospholipase A2

What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?

Phospholipids of cell membranes

Which of the following mediators are formed from arachidonic acid and play a role in inflammation?

Prostaglandins and leukotrienes

What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?

Presence of a larger amino acid in COX-2

Which factor has permitted the development of selective COX-2 inhibitors?

Differences in binding site shape

What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?

It makes the active site 20% larger than COX-1

Learn about the potential risk of exacerbating asthma symptoms when using NSAIDs due to their inhibition of prostaglandin synthesis and subsequent increase in leukotriene production. Understand the enzymatic structure of cyclooxygenases (COX-1 and COX-2) and their role in this process.

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