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Questions and Answers
Which of the following is a potential risk associated with NSAID use in patients with asthma?
Which of the following is a potential risk associated with NSAID use in patients with asthma?
- Exacerbation of asthma symptoms (correct)
- Increased prostaglandin synthesis
- Enhanced bronchodilation
- Decreased leukotriene production
What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?
What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?
- Inhibition of leukotriene synthesis but not prostaglandin synthesis
- Inhibition of both prostaglandin and leukotriene synthesis
- Enhancement of prostaglandin synthesis
- Inhibition of prostaglandin synthesis but not leukotriene synthesis (correct)
Why should NSAIDs be used with caution in patients with asthma?
Why should NSAIDs be used with caution in patients with asthma?
- They enhance bronchodilation
- They decrease leukotriene production
- They inhibit prostaglandin synthesis, potentially increasing the risk of asthma exacerbations (correct)
- They have no effect on asthma symptoms
Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?
Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?
What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?
What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?
Which of the following mediators are formed from arachidonic acid and play a role in inflammation?
Which of the following mediators are formed from arachidonic acid and play a role in inflammation?
What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?
What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?
Which factor has permitted the development of selective COX-2 inhibitors?
Which factor has permitted the development of selective COX-2 inhibitors?
What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?
What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?
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