NSAIDs and Asthma Risk
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Questions and Answers

Which of the following is a potential risk associated with NSAID use in patients with asthma?

  • Exacerbation of asthma symptoms (correct)
  • Increased prostaglandin synthesis
  • Enhanced bronchodilation
  • Decreased leukotriene production

What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?

  • Inhibition of leukotriene synthesis but not prostaglandin synthesis
  • Inhibition of both prostaglandin and leukotriene synthesis
  • Enhancement of prostaglandin synthesis
  • Inhibition of prostaglandin synthesis but not leukotriene synthesis (correct)

Why should NSAIDs be used with caution in patients with asthma?

  • They enhance bronchodilation
  • They decrease leukotriene production
  • They inhibit prostaglandin synthesis, potentially increasing the risk of asthma exacerbations (correct)
  • They have no effect on asthma symptoms

Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?

<p>Phospholipase A2 (B)</p> Signup and view all the answers

What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?

<p>Phospholipids of cell membranes (A)</p> Signup and view all the answers

Which of the following mediators are formed from arachidonic acid and play a role in inflammation?

<p>Prostaglandins and leukotrienes (D)</p> Signup and view all the answers

What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?

<p>Presence of a larger amino acid in COX-2 (D)</p> Signup and view all the answers

Which factor has permitted the development of selective COX-2 inhibitors?

<p>Differences in binding site shape (B)</p> Signup and view all the answers

What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?

<p>It makes the active site 20% larger than COX-1 (C)</p> Signup and view all the answers

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