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NSAIDs and Asthma Risk
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NSAIDs and Asthma Risk

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Questions and Answers

Which of the following is a potential risk associated with NSAID use in patients with asthma?

  • Exacerbation of asthma symptoms (correct)
  • Increased prostaglandin synthesis
  • Enhanced bronchodilation
  • Decreased leukotriene production

    • What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?

  • Inhibition of leukotriene synthesis but not prostaglandin synthesis
  • Inhibition of both prostaglandin and leukotriene synthesis
  • Enhancement of prostaglandin synthesis
  • Inhibition of prostaglandin synthesis but not leukotriene synthesis (correct)

    • Why should NSAIDs be used with caution in patients with asthma?

  • They enhance bronchodilation
  • They decrease leukotriene production
  • They inhibit prostaglandin synthesis, potentially increasing the risk of asthma exacerbations (correct)
  • They have no effect on asthma symptoms

    • Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?

    <p>Phospholipase A2</p> Signup and view all the answers

    What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?

    <p>Phospholipids of cell membranes</p> Signup and view all the answers

    Which of the following mediators are formed from arachidonic acid and play a role in inflammation?

    <p>Prostaglandins and leukotrienes</p> Signup and view all the answers

    What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?

    <p>Presence of a larger amino acid in COX-2</p> Signup and view all the answers

    Which factor has permitted the development of selective COX-2 inhibitors?

    <p>Differences in binding site shape</p> Signup and view all the answers

    What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?

    <p>It makes the active site 20% larger than COX-1</p> Signup and view all the answers

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