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NSAIDs and Asthma Risk

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Questions and Answers

Which of the following is a potential risk associated with NSAID use in patients with asthma?

Exacerbation of asthma symptoms (correct)

Increased prostaglandin synthesis

Enhanced bronchodilation

Decreased leukotriene production

What is the main effect of NSAIDs on prostaglandins and leukotrienes synthesis?

Inhibition of leukotriene synthesis but not prostaglandin synthesis

Inhibition of both prostaglandin and leukotriene synthesis

Enhancement of prostaglandin synthesis

Inhibition of prostaglandin synthesis but not leukotriene synthesis (correct)

Why should NSAIDs be used with caution in patients with asthma?

They enhance bronchodilation

They decrease leukotriene production

They inhibit prostaglandin synthesis, potentially increasing the risk of asthma exacerbations (correct)

They have no effect on asthma symptoms

Which enzyme is responsible for releasing arachidonic acid from cell membrane phospholipids?

Phospholipase A2 (B) Signup and view all the answers

What is the primary source of arachidonic acid for the formation of inflammatory mediators in the body?

Phospholipids of cell membranes (A) Signup and view all the answers

Which of the following mediators are formed from arachidonic acid and play a role in inflammation?

Prostaglandins and leukotrienes (D) Signup and view all the answers

What is the primary reason for the approximately 20% larger active site for COX-2 compared to COX-1?

Presence of a larger amino acid in COX-2 (D) Signup and view all the answers

Which factor has permitted the development of selective COX-2 inhibitors?

Differences in binding site shape (B) Signup and view all the answers

What is the impact of the replacement of Ile-523 with Val-509 in COX-2 on the active site?

It makes the active site 20% larger than COX-1 (C) Signup and view all the answers