Questions and Answers
What is the drug name for (NSAID) Propionic Acids?
Ibuprofen
Name the drugs under (NSAID) Acetic Type.
Diclofenac and Ketorolac
What is the drug name for (NSAID) Cyclooxygenase-2 inhibitors?
Celecoxib
Diclofenac Route: ______. Ketorolac Route: ______.
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Diclofenac is used for ______ pain associated with inflammatory conditions in adults. Ketorolac is used for ______ pain in adults.
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What are the classes of anti-inflammatory, anti-arthritis, and related agents?
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What are the indications of Ibuprofen?
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What is Ibuprofen intended to treat?
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What is the pharmacokinetics of Ibuprofen?
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How is Ibuprofen excreted?
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What are the contraindications of Ibuprofen?
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What are the cautions with Ibuprofen?
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What are the drug interactions for Ibuprofen?
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What is the route of Diclofenac?
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What are the indications for Diclofenac?
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What is the pharmacokinetics of Diclofenac?
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How is Diclofenac excreted?
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What does Salicylate inhibit?
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What are the indications for Salicylate?
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Where is Salicylate metabolized?
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What are the contraindications of Salicylate?
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Where is Salicylate excreted?
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How would you advise a patient to take Salicylate?
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What is the risk of giving a child Salicylate?
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What would you monitor when a patient is on Salicylate?
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What lab tests would you monitor for a patient on Salicylate?
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Study Notes
NSAID Drug Classifications
- Propionic Acids: Major drug is Ibuprofen.
- Acetic Acid Derivatives: Include Diclofenac and Ketorolac.
- Cyclooxygenase-2 Inhibitors: The primary drug is Celecoxib.
Route of Administration
- Diclofenac: Can be administered topically and orally (PO).
- Ketorolac: Available in PO, IV, and IM routes.
Treatment Indications
- Diclofenac: Used for acute and chronic inflammatory pain in adults.
- Ketorolac: Intended for short-term pain management in adults.
Anti-inflammatory Classes
- Includes Salicylates, NSAIDs, Acetaminophen, anti-arthritis medications, and DMARDs.
Ibuprofen Overview
- Inhibits cyclooxygenase, leading to decreased synthesis of prostaglandins and thromboxane.
- Indications include pain relief, arthritis treatment, dysmenorrhea, and juvenile arthritis.
Pharmacokinetics and Excretion of Ibuprofen
- Metabolized by CYP 450 system.
- Primarily excreted through the kidneys.
Contraindications and Cautions for Ibuprofen
- Contraindications: Known allergies to NSAIDs or salicylates, cardiovascular dysfunction, hypertension, peptic ulcers, GI bleeding, and pregnancy.
- Cautions: Use with care in patients with renal or hepatic dysfunction.
Drug Interactions with Ibuprofen
- Can decrease the effectiveness of loop diuretics and beta blockers.
- Potential risk of lithium toxicity when used with Ibuprofen.
Diclofenac Overview
- Routes: Administered topically and orally (PO).
- Indicated for acute and chronic pain due to inflammatory conditions, as well as arthritis and dysmenorrhea.
- Metabolized by liver CYP450 and excreted via the kidneys.
Salicylates Overview
- Inhibit synthesis of prostaglandins, key mediators of inflammation.
- Indications include mild to moderate pain, fever, inflammatory conditions, and low-dose prevention of myocardial infarction (MI).
Metabolism and Excretion of Salicylates
- Metabolized in the liver; excreted in urine.
Contraindications for Salicylates
- Known allergies, bleeding disorders (due to effects on clotting), and impaired renal function necessitating caution.
Patient Guidance for Salicylates
- Recommended to take with food if experiencing GI upset, small frequent meals helpful, and adequate hydration to reduce toxicity risk.
Risks and Monitoring for Salicylates
- Reye Syndrome: A significant risk when administered to children.
- Monitoring includes pulse, blood pressure (BP), and perfusion to detect bleeding or cardiovascular issues.
- Laboratory tests: CBC, liver and renal function tests, urinalysis, stool guaiac, and clotting times are essential to assess drug effects and functions.
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Test your knowledge on the classification of NSAIDs with these flashcards. Each card provides information about different types of NSAIDs, their specific drugs, and routes of administration. Perfect for students and professionals in the medical field.