NSAID Classification Flashcards

Questions and Answers

What is the drug name for (NSAID) Propionic Acids?

Ibuprofen

Name the drugs under (NSAID) Acetic Type.

Diclofenac and Ketorolac

What is the drug name for (NSAID) Cyclooxygenase-2 inhibitors?

Celecoxib

Diclofenac Route: . Ketorolac Route: .

Topical and PO / PO, IV, IM Signup and view all the answers

Diclofenac is used for pain associated with inflammatory conditions in adults. Ketorolac is used for pain in adults.

acute and chronic / short-term management of Signup and view all the answers

What are the classes of anti-inflammatory, anti-arthritis, and related agents?

Salicylates, NSAID, Acetaminophen, Anti-arthritis, DMARDS Signup and view all the answers

What are the indications of Ibuprofen?

Inhibit cyclooxygenase, reducing prostaglandin and thromboxane synthesis. Signup and view all the answers

What is Ibuprofen intended to treat?

Pain, Arthritis, Dysmenorrhea, Juvenile arthritis Signup and view all the answers

What is the pharmacokinetics of Ibuprofen?

CYP 450 Signup and view all the answers

How is Ibuprofen excreted?

Kidneys Signup and view all the answers

What are the contraindications of Ibuprofen?

Allergy to any NSAIDS, Contraindicated to sulfonamides, Cardiovascular dysfunction, Hypertension, Peptic ulcer, GI bleeding, and pregnancy. Signup and view all the answers

What are the cautions with Ibuprofen?

Renal and hepatic dysfunction Signup and view all the answers

What are the drug interactions for Ibuprofen?

Decrease diuretic effect with loop diuretics and potential to decrease antihypertensive effect of beta blockers. Signup and view all the answers

What is the route of Diclofenac?

Topical and PO Signup and view all the answers

What are the indications for Diclofenac?

Acute and chronic pain due to inflammatory response in adults, Pain, Arthritis, Dysmenorrhea, Juvenile arthritis Signup and view all the answers

What is the pharmacokinetics of Diclofenac?

Liver CYP450 Signup and view all the answers

How is Diclofenac excreted?

Through the kidney Signup and view all the answers

What does Salicylate inhibit?

Inhibits the synthesis of prostaglandin. Signup and view all the answers

What are the indications for Salicylate?

Treatment of mild and moderate pain, Fever, Inflammatory conditions, Prevention of ischemic attacks Signup and view all the answers

Where is Salicylate metabolized?

In the liver Signup and view all the answers

What are the contraindications of Salicylate?

Known allergy, Bleeding abnormalities, Impaired renal functions Signup and view all the answers

Where is Salicylate excreted?

In the urine Signup and view all the answers

How would you advise a patient to take Salicylate?

With food if upset is severe, small frequent meals, stay well hydrated. Signup and view all the answers

What is the risk of giving a child Salicylate?

Reye syndrome Signup and view all the answers

What would you monitor when a patient is on Salicylate?

Pulse, BP, Perfusion Signup and view all the answers

What lab tests would you monitor for a patient on Salicylate?

CBC, Liver and renal function tests, Urinalysis, Stool guaiac, Clotting times Signup and view all the answers

Study Notes

NSAID Drug Classifications

Propionic Acids: Major drug is Ibuprofen.
Acetic Acid Derivatives: Include Diclofenac and Ketorolac.
Cyclooxygenase-2 Inhibitors: The primary drug is Celecoxib.

Route of Administration

Diclofenac: Can be administered topically and orally (PO).
Ketorolac: Available in PO, IV, and IM routes.

Treatment Indications

Diclofenac: Used for acute and chronic inflammatory pain in adults.
Ketorolac: Intended for short-term pain management in adults.

Anti-inflammatory Classes

Includes Salicylates, NSAIDs, Acetaminophen, anti-arthritis medications, and DMARDs.

Ibuprofen Overview

Inhibits cyclooxygenase, leading to decreased synthesis of prostaglandins and thromboxane.
Indications include pain relief, arthritis treatment, dysmenorrhea, and juvenile arthritis.

Pharmacokinetics and Excretion of Ibuprofen

Metabolized by CYP 450 system.
Primarily excreted through the kidneys.

Contraindications and Cautions for Ibuprofen

Contraindications: Known allergies to NSAIDs or salicylates, cardiovascular dysfunction, hypertension, peptic ulcers, GI bleeding, and pregnancy.
Cautions: Use with care in patients with renal or hepatic dysfunction.

Drug Interactions with Ibuprofen

Can decrease the effectiveness of loop diuretics and beta blockers.
Potential risk of lithium toxicity when used with Ibuprofen.

Diclofenac Overview

Routes: Administered topically and orally (PO).
Indicated for acute and chronic pain due to inflammatory conditions, as well as arthritis and dysmenorrhea.
Metabolized by liver CYP450 and excreted via the kidneys.

Salicylates Overview

Inhibit synthesis of prostaglandins, key mediators of inflammation.
Indications include mild to moderate pain, fever, inflammatory conditions, and low-dose prevention of myocardial infarction (MI).

Metabolism and Excretion of Salicylates

Metabolized in the liver; excreted in urine.

Contraindications for Salicylates

Known allergies, bleeding disorders (due to effects on clotting), and impaired renal function necessitating caution.

Patient Guidance for Salicylates

Recommended to take with food if experiencing GI upset, small frequent meals helpful, and adequate hydration to reduce toxicity risk.

Risks and Monitoring for Salicylates

Reye Syndrome: A significant risk when administered to children.
Monitoring includes pulse, blood pressure (BP), and perfusion to detect bleeding or cardiovascular issues.
Laboratory tests: CBC, liver and renal function tests, urinalysis, stool guaiac, and clotting times are essential to assess drug effects and functions.

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Description

Test your knowledge on the classification of NSAIDs with these flashcards. Each card provides information about different types of NSAIDs, their specific drugs, and routes of administration. Perfect for students and professionals in the medical field.