Normal Hemostasis and Coagulation Overview

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What is the primary function of the platelet plasma membrane?

To selectively allow the passage of substances in and out of the platelet (correct)
To store coagulation factors for release during activation
To produce energy for platelet activation
To provide structural support for the platelet

Which of the following phospholipids is found on the inner, cytoplasmic layer of the platelet plasma membrane?

Phosphatidylinositol (correct)
Phosphatidylserine
Sphingomyelin
Phosphatidylcholine

What is the function of the platelet glycocalyx?

To provide structural support for the platelet
To absorb plasma proteins through endocytosis (correct)
To store coagulation factors for release during activation
To produce energy for platelet activation

Which integrin receptor on the platelet membrane binds to collagen?

∝2β1 (A) Signup and view all the answers

What is the function of the Surface-Connected Canalicular System (SCCS) in platelets?

To provide a network of channels for the passage of substances in and out of the platelet (B) Signup and view all the answers

Which of the following is NOT a component of the platelet plasma membrane?

Mitochondria (C) Signup and view all the answers

What is the molecular weight of high-molecular-weight kininogen (HMWK)?

120,000 Daltons (D) Signup and view all the answers

What percentage of kininogen does HMWK make up in the plasma?

20% (C) Signup and view all the answers

What is the half-life of high-molecular-weight kininogen (HMWK) in the plasma?

156 hours (D) Signup and view all the answers

Which of the following is NOT a name for high-molecular-weight kininogen (HMWK)?

Heparin cofactor (A) Signup and view all the answers

What is the mean plasma concentration of high-molecular-weight kininogen (HMWK)?

35-50 ug/mL (B) Signup and view all the answers

Which of the following is NOT a naturally occurring inhibitor of coagulation?

Lupus anticoagulant (D) Signup and view all the answers

What are the two phases involved in normal hemostasis?

Primary and secondary (D) Signup and view all the answers

Which of the following is NOT involved in the maintenance of blood flow within the vascular system?

Fibrinolysis (B) Signup and view all the answers

What is the main function of vasoconstriction in normal hemostasis?

To reduce blood loss through constricting blood vessels (D) Signup and view all the answers

Which phase of normal hemostasis involves platelet adhesion & aggregation?

Primary phase (D) Signup and view all the answers

What is the key role of coagulation enzyme activation in hemostasis?

Stopping bleeding by forming a stable clot (C) Signup and view all the answers

What is the primary role of von Willebrand factor (vWf) in primary hemostasis?

To capture and slow down circulating platelets (A) Signup and view all the answers

Which of the following is the correct sequence of events in primary hemostasis?

Platelet capture, platelet adhesion, platelet activation, platelet secretion, platelet aggregation (C) Signup and view all the answers

What is the primary function of thrombin in primary hemostasis?

To activate platelets and recruit additional platelets (B) Signup and view all the answers

Which of the following statements is true regarding the eicosanoid synthesis pathway?

It is also known as the prostaglandin or cyclooxygenase pathway (B) Signup and view all the answers

What is the primary function of phospholipase A2 in the eicosanoid synthesis pathway?

To release arachidonic acid from membrane phosphatidylinositol (A) Signup and view all the answers

What is the primary function of thromboxane A2 (TXA2) in primary hemostasis?

To activate platelets (B) Signup and view all the answers

What is the primary role of plasmin in the fibrinolytic system?

To degrade fibrin and restore blood flow (C) Signup and view all the answers

Which of the following correctly describes the activation of the fibrinolytic system?

TPA and UPA activate fibrin-bound plasminogen several hours after clot formation (A) Signup and view all the answers

Which of the following inhibitors is considered the principal inhibitor of plasmin?

$\alpha_2$-Antiplasmin (B) Signup and view all the answers

What is the primary function of Protein C and Protein S in the fibrinolytic system?

To inactivate inhibitors of plasminogen activators, enhancing fibrinolysis (A) Signup and view all the answers

Which of the following statements regarding the activation of the fibrinolytic system is correct?

The fibrinolytic system can be activated by both intrinsic and extrinsic factors (D) Signup and view all the answers

Which of the following inhibitors is considered the principal inhibitor of the coagulation cascade?

Antithrombin III (B) Signup and view all the answers