Normal Hemostasis and Coagulation

Response to vascular injury

Fibrinolysis

To maintain blood in a fluid state within normal vessels

<p>It involves the interaction of vasoconstriction, platelet adhesion and aggregation, and coagulation enzyme activation</p> Signup and view all the answers

<p>Vasodilation</p> Signup and view all the answers

<p>They are thick, circumferential bundles that reside just within the plasma membrane, maintaining the platelet's discoid shape.</p> Signup and view all the answers

<p>They contain adenosine diphosphate (ADP) and adenosine triphosphate (ATP).</p> Signup and view all the answers

<p>To store and release substances that promote vasoconstriction and platelet activation.</p> Signup and view all the answers

<p>50 to 80</p> Signup and view all the answers

<p>They contain proteins that participate in secondary hemostasis (coagulation).</p> Signup and view all the answers

<p>84-70 hours</p> Signup and view all the answers

<p>Factor XI</p> Signup and view all the answers

<p>It can be tested in serum.</p> Signup and view all the answers

<p>3 mg/dL</p> Signup and view all the answers

<p>It is partially adsorbed by $\mathrm{BaSO_4}$ and Celite but not by $\mathrm{Al(OH)_3}$.</p> Signup and view all the answers

<p>Releasing plasminogen activator inhibitors (PAIs)</p> Signup and view all the answers

<p>Inhibiting platelet aggregation and coagulation activation</p> Signup and view all the answers

<p>Endothelial cells release tissue factor, which increases the catalytic function of factors IXa and Xa.</p> Signup and view all the answers

<p>Collagen promotes platelet adhesion, while tissue factor activates coagulation.</p> Signup and view all the answers

<p>It inhibits platelet aggregation, prevents coagulation activation, and enhances fibrinolysis.</p> Signup and view all the answers

<p>Endothelial cells release tissue-type plasminogen activator (t-PA) to degrade fibrin and dissolve thrombi.</p> Signup and view all the answers

<p>TXA2 suppresses adenylate cyclase, reducing cyclic AMP concentration and allowing the release of ionic calcium from the DTS, which supports actin microfilament contraction and platelet activation.</p> Signup and view all the answers

<p>G-protein activates phospholipase C, which cleaves membrane phosphatidylinositol 4,5-biphosphate to form IP3 and DAG. IP3 promotes the release of ionic calcium from the DTS, which activates actin microfilament contraction, while DAG activates phosphokinase C, triggering the phosphorylation of pleckstrin and regulating actin microfilament contraction.</p> Signup and view all the answers

<p>GP Ib/IX/V, GP VI, and 21 (GP Ia/IIa) receptors bind to collagen, causing the platelet to become firmly attached to the damaged surface, where it subsequently loses its discoid shape and spreads.</p> Signup and view all the answers

<p>TXA2 and ADP are secreted from the platelet to the microenvironment, where they activate adjacent platelets through their respective receptors and provide inside-out activation of IIb3 (GP IIb/IIIa), which assists in platelet aggregation.</p> Signup and view all the answers