Non-Mendelian Inheritance Patterns

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Questions and Answers

The pattern of inheritance for a trait where the heterozygous genotype shows an intermediate phenotype is called ______.

incomplete dominance

In human blood type inheritance, the pattern of inheritance involving multiple alleles is observed, where the A, B, and O alleles determine blood type is called ______.

multiple alleles

The pattern of inheritance involving the contribution of multiple genes to produce a single trait is known as ______.

polygenic inheritance

When both alleles of a gene are fully expressed in the heterozygous condition, the pattern of inheritance is called ______.

<p>codominance</p>
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When one gene's expression is influenced by the expression of another gene, it is referred to as ______.

<p>epistasis</p>
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In a study of skin color in humans, it is observed that skin color is determined by the cumulative effect of multiple genes located on different chromosomes. Individuals with a combination of alleles from multiple genes may exhibit a wide range of skin tones. This pattern of inheritance is known as ______.

<p>polygenic inheritance</p>
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Tay-Sachs disease is a rare genetic disorder characterized by the absence of an enzyme necessary to break down lipids called gangliosides. Individuals who inherit two copies of the defective allele typically do not survive past early childhood due to severe neurological degeneration. This condition is an example of ______.

<p>lethal genes</p>
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Ichthyosis is a skin disorder characterized by dry, scaly skin. The condition is caused by mutations in the steroid sulfatase gene (STS) located on the X chromosome. This is an example of ______.

<p>sex-linked inheritance</p>
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In sweet peas, flower color is determined by two genes: the P gene (purple pigment) and the W gene (white pigment). However, if an individual is homozygous recessive for the P gene (pp), the expression of the W gene determines the flower color. This interaction is called ______.

<p>epistasis</p>
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In a certain species of reptiles, scale color is determined by two genes, A and B. Gene A controls the production of pigment, while gene B controls the distribution of pigment. Reptiles with a bb genotype will have no pigment in their scales, regardless of the genotype at gene A. This is an example of ______.

<p>epistasis</p>
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In a certain species of reptiles, scale color is determined by two genes, A and B. If two reptiles with the genotype AaBb are crossed, the probability of having an offspring with unpigmented scales is ______.

<p>7/16</p>
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The key difference between autosomal and sex-linked disorders is that autosomal disorders are caused by genes located on ______, while sex-linked disorders are caused by genes located on sex chromosomes.

<p>autosomes</p>
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A couple has one child affected by albinism, an autosomal recessive disorder. If both parents have normal pigmentation and there is a 50% chance their child becomes a carrier of the disorder, the correct genotype of the parents is ______.

<p>Aa x Aa</p>
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If two organisms with genotypes Aa and aa for albinism mate, the percent chance of having an affected son is ______.

<p>25%</p>
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Huntington's disease is an autosomal dominant disorder. An affected individual who is homozygous for the disease mates with a normal person. The probability of having an affected child is ______.

<p>100%</p>
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Huntington's disease is an autosomal dominant disorder. If an affected individual who is homozygous mates with a normal person and they have 10 children, the number of children expected to be affected is ______.

<p>10</p>
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Huntington's disease is an autosomal dominant disorder. An affected individual who is homozygous for the disease mates with a normal person. Therefore, the probability of having a daughter who is affected by the disease is ______.

<p>100%</p>
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______ is the application of biological principles, processes, and systems to develop products and technologies that benefit society, industry, and the environment.

<p>biotechnology</p>
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Organisms that have been modified through genetic engineering techniques are best defined as ______.

<p>genetically modified organisms</p>
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The primary goal of recombinant DNA technology is to ______ DNA to create new genetic combinations.

<p>manipulate</p>
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______ are commonly used to cut DNA molecules at specific sequences in recombinant DNA technology.

<p>restriction enzymes</p>
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A ______ is a vector for transferring DNA into a host cell in recombinant DNA technology.

<p>plasmid</p>
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In recombinant DNA technology, the purpose of using selectable markers is to distinguish ______ cells from non-transformed cells.

<p>transformed</p>
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A pattern of inheritance where the heterozygous genotype results in a phenotype that is a mix of both homozygous phenotypes showcases ______.

<p>codominance</p>
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When a single gene influences multiple distinct phenotypic traits, such as in Marfan syndrome, it is known as ______.

<p>pleiotropy</p>
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Traits that are influenced by multiple genes resulting in a continuous range of phenotypes demonstrate ______.

<p>polygenic inheritance</p>
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In shorthorn cattle, the roan coat color (a mix of red and white hairs) is an example of ______, as neither red nor white is dominant.

<p>codominance</p>
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Genes located on the same chromosome that tend to be inherited together are referred to as ______.

<p>linked genes</p>
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When the expression of one gene masks or modifies the expression of another gene, you have ______.

<p>epistasis</p>
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Flashcards

Incomplete Dominance

A pattern of inheritance where the heterozygous genotype results in an intermediate phenotype.

Codominance

A pattern of inheritance where both alleles of a gene are fully expressed in the heterozygous condition.

Multiple Alleles

The multiple allelic inheritance pattern of human blood types

Polygenic Inheritance

When multiple genes contribute to a single trait.

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Epistasis

One gene's expression is influenced by the expression of another gene.

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Lethal genes

Genes that, when inherited, can cause the death of an organism before it reaches reproductive age.

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Sex-linked inheritance

Inheritance patterns affecting genes located on sex chromosomes.

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Genetically Modified Organisms (GMOs)

Organisms modified through genetic engineering techniques.

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Recombinant DNA Technology

Manipulating DNA to create new genetic combinations.

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Restriction enzymes

Enzymes used to cut DNA molecules at specific sequences.

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Plasmids in recombinant DNA

Vectors for transferring DNA into a host cell.

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Selectable markers

The use of markers to distinguish transformed cells from non-transformed cells.

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Study Notes

Non-Mendelian Inheritance

  • This refers to the inheritance patterns that do not follow Mendel's laws.
  • Includes incomplete dominance, codominance, multiple alleles, pleiotropy, polygenic inheritance, epistasis, and sex-linked and sex-influenced inheritance.

Incomplete Dominance

  • It occurs when the heterozygous genotype displays an intermediate phenotype.

Multiple Alleles

  • It occurs when a gene has more than two alleles in a population such as in human blood type inheritance.

Polygenic Inheritance

  • Several genes contribute to a single trait.
  • An example is human skin color, which is determined by the cumulative effect of multiple genes on different chromosomes and individuals exhibit a wide range of skin tones.

Codominance

  • It occurs when both alleles of a gene are fully expressed in the heterozygous condition.

Epistasis

  • This occurs when one gene's expression is influenced by the expression of another gene.
  • For example, in sweet peas, flower color is determined by two genes: the P gene (purple pigment) and the W gene (white pigment). The presence of at least one dominant allele at either locus (PP or Pw) will produce purple flowers. However, if an individual is homozygous recessive for the P gene (pp), the expression of the W gene determines the flower color.

Lethal Genes

  • When individuals inherit two copies of the defective allele (homozygous recessive), they typically do not survive past early childhood due to the severe neurological degeneration associated with the condition/disease.
  • Tay-Sachs disease, a rare genetic disorder characterized by the absence of an enzyme necessary to break down lipids called gangliosides.

Sex-linked Inheritance

  • This occurs when a gene is located on a sex chromosome such as the X chromosome resulting in conditions such as ichthyosis, a skin disorder characterized by dry, scaly skin, is caused by mutations in the steroid sulfatase gene (STS) located on the X chromosome.

Problem Solving Examples

  • Reptiles with a bb genotype will have no pigment in scales, regardless of gene A's genotype, due to epistasis, because if two reptiles with the genotype AaBb are crossed, the probability of having an offspring with unpigmented scales is 7/16.
  • Autosomal disorders are caused by genes located on autosomes, while sex-linked disorders are caused by genes located on sex chromosomes.
  • If both parents have normal pigmentation and a couple has one child affected by albinism (autosomal recessive disorder) the parents genotypes are AA x Aa if 50% of their child becomes a carrier of the disorder.
  • If two organisms with genotypes Aa and aa for albinism mate, there is a 25% chance of having an affected son.
  • In Huntington's disease, the probability of having an affected child by an homozygous affected individual paired with a normal individual is 100%.
  • If a person with Huntington's disease mates with a normal partner and they have 10 kids, then 10 of their kids would equally be affected.
  • If a person with Huntington's disease mates with a normal partner, there is a 50% chance of a daughter being affected by the disease.

Biotechnology

  • Involves applying biological principles, processes, and systems to develop products and technologies that benefit society, industry, and the environment.
  • Benefits include improving human health, enhancing agriculture and food production, environmental protection and remediation, industrial applications, research, and innovation.

Genetically Modified Organisms (GMOs)

  • Defined as organisms modified through genetic engineering techniques.

Recombinant DNA Technology

  • The primary goal is to manipulate DNA to create new genetic combinations.

Restriction enzymes

  • Commonly used to cut DNA molecules at specific sequences in recombinant DNA technology.

Plasmids

  • Act as a vector for transferring DNA into a host cell in recombinant DNA technology.

Selectable markers

  • Used to distinguish transformed cells from non-transformed cells in recombinant DNA technology.

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