10 Questions
What may become saturated in the processes of drug absorption, distribution, biotransformation, and excretion when drugs are given at therapeutic levels?
Enzymes or carrier-mediated systems
What term is used to describe the pharmacokinetic behavior observed when increased doses or chronic medication cause deviations from the linear pharmacokinetic profile observed with single low doses of the same drug?
Dose-dependent pharmacokinetics
What causes alterations in drug absorption, distribution, and elimination, leading to non-linear pharmacokinetic behavior?
Pathologic alteration
What causes renal nephrotoxicity, thereby altering renal drug excretion according to the text?
Aminoglycosides
What type of kinetics is referred to when pharmacokinetic parameters change with the size of the administered dose?
Non-linear pharmacokinetics
What is the term used to describe the pharmacokinetic behavior observed when increased doses or chronic medication cause deviations from the linear pharmacokinetic profile observed with single low doses of the same drug?
Non-linear pharmacokinetics
What may become saturated in the processes of drug absorption, distribution, biotransformation, and excretion when drugs are given at therapeutic levels?
Enzymes or carrier-mediated systems
What type of kinetics is referred to when pharmacokinetic parameters change with the size of the administered dose?
Non-linear pharmacokinetics
What causes alterations in drug absorption, distribution, and elimination, leading to non-linear pharmacokinetic behavior?
Pathologic alteration in drug processes
What is altered by increased doses or chronic medication, leading to deviations from the linear pharmacokinetic profile observed with single low doses of the same drug?
Pharmacokinetic parameters
Study Notes
Pharmacokinetic Behavior and Non-Linearity
- Enzymes, transport mechanisms, and receptors involved in drug absorption, distribution, biotransformation, and excretion may become saturated when drugs are given at therapeutic levels, leading to non-linear pharmacokinetic behavior.
Non-Linear Pharmacokinetics
- Non-linear pharmacokinetics is described as the pharmacokinetic behavior observed when increased doses or chronic medication cause deviations from the linear pharmacokinetic profile observed with single low doses of the same drug.
Causes of Non-Linear Pharmacokinetics
- Alterations in drug absorption, distribution, and elimination, leading to non-linear pharmacokinetic behavior, are caused by saturation of enzymes, transport mechanisms, and receptors involved in these processes.
- Renal nephrotoxicity, which alters renal drug excretion, is caused by the accumulation of toxic substances in the kidneys.
Dose-Dependent Pharmacokinetics
- Non-linear pharmacokinetics, where pharmacokinetic parameters change with the size of the administered dose, is referred to as dose-dependent kinetics.
- Increased doses or chronic medication can alter enzymes, transport mechanisms, and receptors involved in drug absorption, distribution, biotransformation, and excretion, leading to deviations from the linear pharmacokinetic profile observed with single low doses of the same drug.
Test your knowledge on non-linear pharmacokinetics, including dose-dependent pharmacokinetics, capacity limited kinetics, and causes of non-linear pharmacokinetic behavior.
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