Non-inflammatory Arthropathies Lecture
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Non-inflammatory Arthropathies Lecture

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Questions and Answers

Which type of arthritis is characterized by inflammation of one or more joints?

  • Osteoarthritis
  • Rheumatoid arthritis (correct)
  • Gout
  • Juvenile idiopathic arthritis
  • What is the main function of synovial fluid in a joint?

  • Provides structural support to the joint
  • Transmits force from muscles to bones
  • Surrounds the ends of bones
  • Lubricates the joint (correct)
  • Which connective tissue surrounds the ends of bones in a joint?

  • Joint capsule
  • Articular cartilage (correct)
  • Ligaments
  • Synovium
  • What is the main characteristic of non-inflammatory arthropathies?

    <p>Diseases of the joints without inflammation</p> Signup and view all the answers

    Which type of arthritis is associated with the presence of uric acid crystals in joints?

    <p>Gout</p> Signup and view all the answers

    Which part of the joint secretes synovial fluid?

    <p>Synovium</p> Signup and view all the answers

    What is the most common arthropathy affecting the US population?

    <p>Osteoarthritis</p> Signup and view all the answers

    Which autoimmune disease affects 1-2% of the adult population?

    <p>Rheumatoid arthritis</p> Signup and view all the answers

    What is a risk factor for osteoarthritis?

    <p>Obesity</p> Signup and view all the answers

    Which type of arthritis has a classic triad of symptoms involving the eyes, urinary system, and joints?

    <p>Reactive arthritis</p> Signup and view all the answers

    What is a characteristic feature of rheumatoid arthritis?

    <p>Autoimmune destruction of the joints</p> Signup and view all the answers

    What is a symptom of juvenile idiopathic arthritis?

    <p>Joint stiffness and limited range of motion</p> Signup and view all the answers

    What causes acute episodes of painful joint inflammation in gout?

    <p>Uric acid buildup</p> Signup and view all the answers

    What is a diagnostic method for gout?

    <p>Serology, urinalysis, and synovial fluid aspiration</p> Signup and view all the answers

    Which type of arthritis affects approximately 1 in 1000 children?

    <p>Juvenile idiopathic arthritis</p> Signup and view all the answers

    What are risk factors for gout?

    <p>Genetics and renal disease</p> Signup and view all the answers

    What is the prevalence of Ankylosing Spondylitis?

    <p>0.25%</p> Signup and view all the answers

    What percentage of patients with Ankylosing Spondylitis are HLA-B27 positive?

    <p>90%</p> Signup and view all the answers

    What is the most common ocular manifestation in patients with Ankylosing Spondylitis?

    <p>Acute anterior uveitis</p> Signup and view all the answers

    What percentage of patients with Ankylosing Spondylitis have a family history as a risk factor?

    <p>~25%</p> Signup and view all the answers

    What percentage of cases of Reactive Arthritis resolve with no long-term complications?

    <p>~80-85%</p> Signup and view all the answers

    What is the triad found in approximately 33% of cases involving Reactive Arthritis?

    <p>&quot;Can’t climb a tree&quot;, lower extremities, acute anterior uveitis</p> Signup and view all the answers

    What is the most common gender prevalence in Ankylosing Spondylitis?

    <p>M &gt; F (3X)</p> Signup and view all the answers

    What percentage of patients with Psoriatic Arthropathy are HLA-B27 positive?

    <p>20-40%</p> Signup and view all the answers

    Which inflammatory arthropathy is associated with Crohn’s Disease in 50-60% of cases?

    <p>Ankylosing Spondylitis</p> Signup and view all the answers

    What is the underlying spondylarthropathy in 84% of cases for patients who have iritis and are HLA-B27 positive?

    <p>Ankylosing Spondylitis</p> Signup and view all the answers

    Study Notes

    Common Types of Arthritis and Autoimmune Diseases

    • Osteoarthritis is the most common arthropathy affecting 10-13% of the US population, with knee and hip joints being most commonly affected.
    • Risk factors for osteoarthritis include obesity, autoimmune diseases, increased age, previous joint injury, and repetitive motion.
    • Rheumatoid arthritis is an autoimmune disease that affects 1-2% of the adult population, with a higher prevalence in women and an average onset between 20-30 years.
    • Rheumatoid arthritis is characterized by autoimmune destruction of the joints, leading to joint deformity and reduced life expectancy.
    • Diagnosis of rheumatoid arthritis involves lab tests for rheumatoid factor, anti-cyclic citrullinated peptide antibody, antinuclear antibody, and HLA-DR1 and HLA-DR4.
    • Treatment for rheumatoid arthritis includes disease-modifying anti-rheumatic drugs, biologics, anti-inflammatories, physical therapy, exercise, and surgery.
    • Juvenile idiopathic arthritis is the most common childhood arthritis, affecting approximately 1 in 1000 children, with onset before 16 years and a higher prevalence in females.
    • Symptoms of juvenile idiopathic arthritis include joint stiffness, limited range of motion, systemic symptoms, and ocular manifestations such as anterior uveitis.
    • Gout is characterized by acute episodes of painful joint inflammation caused by uric acid buildup, affecting 3 million cases in the US, with a higher prevalence in men and in African Americans.
    • Risk factors for gout include age, sex, genetics, renal disease, diet, obesity, and systemic diseases such as hypertension, diabetes, and hyperlipidemia.
    • Diagnosis of gout involves serology, urinalysis, and synovial fluid aspiration, and treatment aims to reduce pain, inflammation, and uric acid levels through medication and dietary modifications.
    • Reactive arthritis, also known as Reiter's syndrome, is an inflammatory arthritis occurring after genitourinary or gastrointestinal infection, with a higher prevalence in men and a classic triad of symptoms involving the eyes, urinary system, and joints.

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    Description

    This lecture covers the pathophysiology, clinical findings, and diagnostic principles related to non-inflammatory arthropathies such as osteoarthritis. It also includes an understanding of inflammatory arthropathies like rheumatoid arthritis, JIA, gout, and spondylarthropathies.

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