Non-Germ Cell Tumors of the Scrotum

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Questions and Answers

At what age are non-germ cell tumors typically found in?

Younger boys

What are the types of sex cord-stromal tumors?

  • Leydig cell tumor (correct)
  • Sertoli cell tumor (correct)
  • Granulosa cell tumor (correct)
  • All of the above

Which pathologies can be associated with non-germ cell tumors?

  • Lymphoma (correct)
  • Leukemia (correct)
  • Metastasis (correct)
  • All of the above

Sertoli cell tumors are extremely common.

<p>False (B)</p> Signup and view all the answers

What are the clinical signs and symptoms of a Sertoli cell tumor?

<p>Both A and B (C)</p> Signup and view all the answers

What is the sonographic appearance of a Sertoli cell tumor?

<p>Both A and B (C)</p> Signup and view all the answers

Choriocarcinoma is a rare and aggressive tumor.

<p>True (A)</p> Signup and view all the answers

What are the clinical signs and symptoms of a choriocarcinoma?

<p>Both A and B (C)</p> Signup and view all the answers

Leydig cell tumors are common.

<p>False (B)</p> Signup and view all the answers

What are the clinical signs and symptoms of a Leydig cell tumor?

<p>All of the above (D)</p> Signup and view all the answers

Granulosa cell tumors are common and typically occur in the absence of chromosomal abnormalities.

<p>False (B)</p> Signup and view all the answers

What is a risk factor for the development of a Granulosa cell tumor?

<p>Chromosomal abnormality</p> Signup and view all the answers

What are the clinical signs and symptoms of a Granulosa cell tumor?

<p>Palpable mass (A)</p> Signup and view all the answers

What is the sonographic appearance of a Granulosa cell tumor?

<p>Both A and B (C)</p> Signup and view all the answers

What is an orchiectomy?

<p>Removal of the whole testicle</p> Signup and view all the answers

Lymphoma and leukemia are primary testicular tumors.

<p>False (B)</p> Signup and view all the answers

What percentage of all testicular tumors are malignant lymphoma tumors?

<p>1% to 7%</p> Signup and view all the answers

What is the most common bilateral secondary testicular neoplasm affecting men over 60 years old?

<p>Malignant lymphoma tumors</p> Signup and view all the answers

Leukemia involvement of the testicle is the most common secondary testicular neoplasm.

<p>False (B)</p> Signup and view all the answers

In what age group is leukemia involvement of the testicle most often found?

<p>Children</p> Signup and view all the answers

What percentage of children with leukemia have testicular involvement?

<p>8%</p> Signup and view all the answers

What are the clinical signs and symptoms of leukemia involving the testicle?

<p>All of the above (E)</p> Signup and view all the answers

How do testes appear sonographically in cases of lymphoma and leukemia?

<p>Both A and B (C)</p> Signup and view all the answers

What sonographic appearance is associated with chronic lymphocytic leukemia?

<p>Both A and B (C)</p> Signup and view all the answers

Metastasis to the testicle is common, especially in younger individuals.

<p>False (B)</p> Signup and view all the answers

What are the primary sources of metastases to the testicle?

<p>Both A and B (C)</p> Signup and view all the answers

Which of the following are less common sources of metastasis to the testicle?

<p>All of the above (G)</p> Signup and view all the answers

What sonographic findings are associated with metastasis to the testicle?

<p>All of the above (E)</p> Signup and view all the answers

Flashcards

NON GERM CELL TUMORS Age

Typically occur in younger boys

NON GERM CELL TUMORS

Comprise sex cord-stromal tumors

Types of Sex cord-stromal tumors

Includes Leydig, Sertoli, and Granulosa cell tumors

Associated Pathologies

Includes lymphoma, leukemia, and metastases

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SERTOLI CELL TUMOR

Extremely rare type of tumor

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SERTOLI CELL TUMOR Clinical S & S

Produces estrogen leading to gynecomastia

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SERTOLI CELL TUMOR Sonographic appearance

Appears hypoechoic and hypervascular

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CHORIOCARCINOMA

A rare and aggressive tumor

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CHORIOCARCINOMA Clinical S & S

May be palpable with elevated hCg

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LEYDIG CELL TUMOR

An uncommon testicular tumor

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LEYDIG CELL TUMOR Clinical s&s

Increased testosterone leading to virilization

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GRANULOSA CELL TUMOR

A rare tumor associated with chromosomal abnormalities

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GRANULOSA CELL TUMOR Risk Factor

Patient often has chromosomal abnormality

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GRANULOSA CELL TUMOR Clinical S & S

Palpable without elevated hormone levels

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GRANULOSA CELL TUMOR Sonographic appearance

Appears hypoechoic and hypervascular

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orchiectomy

Surgical removal of the whole testicle

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Lymphoma and Leukemia

Secondary intra-testicular involvement

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Malignant lymphoma tumors

1% to 7% of all testicular tumors, mostly bilateral

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Leukemia involvement of testicle

Next most common secondary testicular neoplasm in children

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8% of children with leukemia

Have testicular involvement

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Leukemia Clinical S&S

Weight loss, anorexia, weakness, enlarged testicle

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Sonographic Findings lymphoma and leukemia

Testes appear homogeneously hypoechoic or focal areas of decreased echogenicity

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Sonographic Appearance Chronic lymphocytic leukemia

Focal well-circumscribed anechoic mass with increased vascularity

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Metastasis

Rare, typically occurs later in life

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Metastasis Original primary tumor may come from

Sources include prostate or kidneys, less often from pancreas, lung, etc.

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Metastasis Sonographic Findings

Can appear hyperechoic, solid, hypoechoic mass, or a combination

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Study Notes

Non-Germ Cell Tumors of the Scrotum

  • Age of onset: Typically younger boys.

  • Types: Sex cord-stromal tumors, including Leydig cell tumors, Sertoli cell tumors, and Granulosa cell tumors.

Sex Cord-Stromal Tumor Types

  • Sertoli Cell Tumor: Extremely rare. Clinically presents with estrogen production and gynecomastia (breast tissue development). Sonographically, it appears hypoechoic and hypervascular.

  • Leydig Cell Tumor: Uncommon. Characterized by increased testosterone levels and virilization (pseudoprecocious puberty).

  • Granulosa Cell Tumor: Rare, often associated with chromosomal abnormalities. Risk factor is chromosomal abnormalities. Clinical presentation may show palpatable mass without elevated hormones. Sonographically appears hypoechoic and hypervascular.

Other Associated Pathologies

  • Lymphoma: 1% to 7% of all testicular tumors, most common in men over 60, frequently bilateral.
  • Leukemia: The next most common secondary testicular neoplasm, more often found in children. 8% of children with leukemia have testicular involvement. Clinical symptoms include weight loss, anorexia, weakness, and an enlarged testicle. Sonographic findings may show homogenous hypoechogenicity or focal decreased echogenicity. Chronic lymphocytic leukemia might present as a well-circumscribed, anechoic mass with enhanced vascularity.
  • Metastasis: Rare, usually appearing later in life. Originates from other cancers (e.g., prostate, kidney, lung, pancreas, bladder, colon, thyroid, or melanoma). Sonographically, the mass might be hyperechoic, solid, hypoechoic, or a mixture of echogenicities.

General Information

  • Orchiectomy: Removal of the entire testicle.
  • Chorioncarcinoma: A rare, aggressive tumor, characterized by palpable mass and elevated hCG levels.

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